RecruitingPhase 1NCT07118176

Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers

PET Imaging Study of 68Ga-FAPI-46 Biodistribution in Cancer Patients


Sponsor

Jonsson Comprehensive Cancer Center

Enrollment

30 participants

Start Date

Aug 1, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

This phase I trial is evaluating a new imaging tracer (68Ga-FAPi-46) with positron emission tomography (PET)/computed tomography (CT) to determine where and to which degree the tracer (68Ga-FAPi-46) accumulates in normal and cancer tissues (the biodistribution) in patients with solid tumors or hematologic (blood) cancers. PET is an established imaging technique that utilizes small amounts of radioactivity attached to very minimal amounts of tracer, in the case of this research, 68Ga-FAPi-46. Because some cancers take up 68Ga-FAPi-46, it can be seen with PET. CT utilizes x-rays that traverse the body from the outside. CT images provide an exact outline of organs and potential inflammatory tissue where it occurs in a patient's body. Combining a PET scan with a CT scan can help make the image easier to interpret. PET/CT scans are hybrid scanners that combine both modalities into a single scan during the same examination.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating how a new imaging tracer called 68Ga-FAPI distributes throughout the body in people with various types of cancer. FAPI tracers attach to a protein found in cancer tissue and can be detected on a PET scan. The goal is to understand how well this tracer identifies tumors across different cancer types. **You may be eligible if...** - You have a suspected or confirmed diagnosis of one of many cancer types, including breast, lung, colorectal, ovarian, pancreatic, liver, bladder, brain, cervical, gastric, head and neck, blood cancers, and others - You are willing to undergo a PET scan with the imaging agent - You have provided informed consent **You may NOT be eligible if...** - You are pregnant or breastfeeding - You have severe kidney or liver impairment - You have a condition that makes PET scanning unsafe - You are unable to provide informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDUREComputed Tomography

Undergo PET/CT

OTHERFludeoxyglucose F-18

Given IV

RADIATIONGallium Ga 68 FAPi-46

Given IV

PROCEDUREPositron Emission Tomography

Undergo PET/CT


Locations(1)

UCLA / Jonsson Comprehensive Cancer Center

Los Angeles, California, United States

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NCT07118176


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