Phase 2 Brain Clinical Trials
151 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 151 trials
Recruiting
Phase 1Phase 2
A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations
CancerBrain Tumor
National Cancer Institute (NCI)96 enrolled1 locationNCT05588141
Recruiting
Phase 2Phase 3
A Study of Buntanetap in Participants With PD
Deep Brain StimulationParkinson's Disease (PD)
Annovis Bio Inc.500 enrolled27 locationsNCT07284784
Recruiting
Phase 2
Dabrafenib and Trametinib for BRAF V600 Mutant Low-Grade Gliomas
BRAF V600 MutationLow-grade GliomaLow Grade Glioma of Brain+1 more
University of California, San Francisco96 enrolled5 locationsNCT07110246
Recruiting
Phase 2
Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique
Brain Metastases
Medical College of Wisconsin53 enrolled2 locationsNCT05045950
Recruiting
Phase 2
A Study Comparing GLIADEL to Stereotactic Radiosurgery in Metastatic Brain Disease
Brain Tumor - Metastatic
University of Nebraska100 enrolled2 locationsNCT04222062
Recruiting
Phase 2
Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII
Central Nervous System DiseasesBrain CancerGlioblastoma Multiforme (GBM)+4 more
Black Diamond Therapeutics, Inc.162 enrolled4 locationsNCT07326566
Recruiting
Phase 1Phase 2
Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
Hypoxia, BrainBlood PressureStroke+5 more
University of Calgary12 enrolled1 locationNCT03255408
Recruiting
Phase 1Phase 2
NBM-BMX Administered Orally to Patients With Solid Tumors or Newly Diagnosed Glioblastoma
Malignant NeoplasmMalignant Neoplasm of Brain
Novelwise Pharmaceutical Corporation79 enrolled4 locationsNCT06012695
Recruiting
Phase 2
An Investigational Scan (18F-DOPA PET/CT) for Improving the Clinical Management of Brain Tumors
Malignant Brain Neoplasm
Mayo Clinic47 enrolled1 locationNCT06667726
Recruiting
Phase 2
Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1
Brain MetastasesCentral Nervous System Cancer
Washington University School of Medicine104 enrolled1 locationNCT07462507
Recruiting
Phase 2
Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
Metastatic Brain TumorGlioblastomaGlioblastoma Multiforme+7 more
Nationwide Children's Hospital120 enrolled21 locationsNCT05843253
Recruiting
Phase 2
NTS-WBRT in Brain Metastases
Brain Metastases
Massachusetts General Hospital41 enrolled1 locationNCT05013892
Recruiting
Phase 2
Phase II Study of Pembrolizumab in Combination With Lenvatinib in Patients With TNBC, NSCLC, and Other Tumor Types and Brain Metastases
Brain MetastasesTumor
M.D. Anderson Cancer Center104 enrolled1 locationNCT05064280
Recruiting
Phase 2
EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active
Brain Metastases
M.D. Anderson Cancer Center316 enrolled1 locationNCT06649058
Recruiting
Phase 2
A Study Utilizing Escitalopram in Glioma Patients
GliomaGlioma of Brain
University of Nebraska20 enrolled1 locationNCT03728673
Recruiting
Phase 2
SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial
Metastatic Malignant Solid NeoplasmMetastatic Malignant Neoplasm in the Brain
Mayo Clinic90 enrolled7 locationsNCT05222620
Recruiting
Phase 2
Super Selective Intra-arterial Repeated Infusion of Cetuximab (Erbitux) With Reirradiation for Treatment of Relapsed/Refractory GBM, AA, and AOA
Brain TumorBrain CancerGlioblastoma+6 more
Northwell Health37 enrolled1 locationNCT02800486
Recruiting
Phase 2
Trial to Study Anti- HCMV Therapy in Breast Cancer Patients With Progressive Intracranial Metastases and CMV Infection
CMV ViremiaBrain Cancer Metastatic
The Methodist Hospital Research Institute28 enrolled1 locationNCT07383649
Recruiting
Phase 1Phase 2
Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas
OsteosarcomaEwing SarcomaNeuroblastoma+4 more
Milton S. Hershey Medical Center289 enrolled10 locationsNCT06465199
Recruiting
Phase 2
Baricitinib for Moderate and Severe Traumatic Intracerebral Hemorrhage/Contusions
Traumatic Brain Injury
Tang-Du Hospital100 enrolled1 locationNCT06065046