Phase 2 Cholangiocarcinoma Clinical Trials
73 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 73 trials
Recruiting
Phase 1Phase 2
Evaluating Efficacy of Tivozanib (AV-951) in Biliary Tract Cancers
CholangiocarcinomaBile Duct NeoplasmBiliary Tract Malignancy
National Cancer Institute (NCI)31 enrolled1 locationNCT04645160
Recruiting
Phase 2
Testing the Combination of the Anticancer Drug Durvalumab With Chemotherapy (Gemcitabine and Cisplatin) at Improving Outcomes for High-Risk Resectable Liver Cancer Before Surgery
Resectable Intrahepatic Cholangiocarcinoma
National Cancer Institute (NCI)27 enrolled58 locationsNCT06050252
Recruiting
Phase 2
Phase II Study of Neoadjuvant Tislelizumab Plus Radiotherapy and GP Chemotherapy for Borderline/Unresectable Hilar Cholangiocarcinoma
CholangiocarcinomaBile Duct CancerHilar Cholangiocarcinoma
Jinbo Yue38 enrolled1 locationNCT07030140
Recruiting
Phase 2
FAPI-PET Value for the Initial Screening of Pancreatic and Biliary Cancers
CholangiocarcinomaPancreatic Adenocarcinoma
University Hospital, Bordeaux120 enrolled1 locationNCT07478523
Recruiting
Phase 2
18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection
Gastric CancerOvarian CancerCholangiocarcinoma+7 more
National Cancer Institute (NCI)320 enrolled1 locationNCT06503146
Recruiting
Phase 2
Gemcitabine and Oxaliplatin Chemotherapy With or Without a Floxuridine and Dexamethasone Pump in People With Cholangiocarcinoma That Cannot Be Removed With Surgery
Intrahepatic Cholangiocarcinoma
Memorial Sloan Kettering Cancer Center164 enrolled11 locationsNCT04891289
Recruiting
Phase 2
Y-90 With Durvalumab/Gem/Cis in Intrahepatic Cholangio
CholangiocarcinomaBile Duct CancerCholangiocarcinoma Non-resectable+2 more
Beth Israel Deaconess Medical Center30 enrolled1 locationNCT05655949
Recruiting
Phase 1Phase 2
Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) Combined With Immune Checkpoint Inhibition After High-Dose External Beam Radiation Therapy in Treating Patients With Unresectable Liver Cancer
Stage III Hepatocellular Carcinoma AJCC v8Stage IV Hepatocellular Carcinoma AJCC v8Unresectable Hepatocellular Carcinoma+3 more
Mayo Clinic85 enrolled1 locationNCT03942328
Recruiting
Phase 2
At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
Advanced Colorectal CarcinomaAdvanced Anal CarcinomaAdvanced Biliary Tract Carcinoma+41 more
Mayo Clinic220 enrolled2 locationsNCT05969860
Recruiting
Phase 2
A Single-Arm Study of Pembrolizumab With Gemcitabine and Cisplatin as Perioperative Therapy for Potentially Resectable Intrahepatic Cholangiocarcinoma
Cholangiocarcinoma
M.D. Anderson Cancer Center24 enrolled1 locationNCT05967182
Recruiting
Phase 2
Agnostic Therapy in Rare Solid Tumors
Cancer of Unknown PrimarySoft Tissue SarcomaCholangiocarcinoma+38 more
Instituto do Cancer do Estado de São Paulo28 enrolled8 locationsNCT06638931
Recruiting
Phase 2
A Phase II Study of Pemigatinib Plus Durvalumab in Previously Treated Advanced Intrahepatic Cholangiocarcinoma Patients With FGFR-2 Fusion or Rearrangement
Intrahepatic CholangiocarcinomaFGFR2 Gene RearrangementFGFR2 Gene Mutation
Mehmet Akce38 enrolled2 locationsNCT06728410
Recruiting
Phase 2
Phase II Study Evaluating Ivosidenib Maintenance After SOC Adjuvant Chemotherapy in Curative mIDH1 Cholangiocarcinoma
CholangiocarcinomaIDH Mutation
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest40 enrolled8 locationsNCT07260175
Recruiting
Phase 2
HYPERION CCA: a Phase 2 Trial of Systemic Therapy With or Without Liver-directed Radiation Therapy for Patients With Advanced Intrahepatic Cholangiocarcinoma
Advanced Intrahepatic Cholangiocarcinoma
M.D. Anderson Cancer Center60 enrolled1 locationNCT06858735
Recruiting
Phase 2
Hepatic Arterial Infusion Chemotherapy (HAIC) Combined With Durvalumab and Lenvatinib in Patients With Locally Advanced or Metastatic Intrahepatic Cholangiocarcinoma: a Phase 2 Study(HAIC-quad Trial)
Intrahepatic Cholangiocarcinoma (Icc)HAICDurvalumab
West China Hospital25 enrolled1 locationNCT06859684
Recruiting
Phase 2
Trial Comparing Standard of Care Therapy With and Without Sequential Cytoreductive Intervention for Patients With Metastatic Foregut Adenocarcinoma and Undetectable Circulating Tumor-Deoxyribose Nucleic Acid (ctDNA) Levels
Esophageal AdenocarcinomaGastric AdenocarcinomaPancreas Adenocarcinoma+6 more
Yale University54 enrolled1 locationNCT07282912
Recruiting
Phase 2
PDS01ADC in Combination With Hepatic Artery Infusion Pump (HAIP) and Systemic Therapy for Subjects With Metastatic Colorectal Cancer, Intrahepatic Cholangiocarcinoma, or Metastatic Adrenocortical Carcinoma
Colorectal NeoplasmsIntrahepatic Cholangiocarcinoma (Icc)Metastatic Colorectal Cancer (Mcrc)+1 more
National Cancer Institute (NCI)70 enrolled1 locationNCT05286814
Recruiting
Phase 2
Trifluridine/Tipiracil + Oxaliplatin in Participants With Advanced or Metastatic Biliary Tract Cancer
Biliary Tract CancerCholangiocarcinomaGallbladder Cancer+2 more
Case Comprehensive Cancer Center27 enrolled2 locationsNCT07146646
Recruiting
Phase 2
PD-1 Antibody Plus GEMOX as Postoperative Adjuvant Therapy in Perihilar Cholangiocarcinoma
Perihilar Cholangiocarcinoma
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University62 enrolled1 locationNCT05430698
Recruiting
Phase 2
REGULUS: MRI-guided Adaptive SABR for Liver Cancers
Liver CancerLiver MetastasesIntrahepatic Cholangiocarcinoma+1 more
Stanford University62 enrolled1 locationNCT07223307