Early Phase 1 Chronic Clinical Trials
37 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 37 trials
Recruiting
Early Phase 1
Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort
Fatigue Syndrome, Chronic
National Institute of Neurological Disorders and Stroke (NINDS)47 enrolled1 locationNCT06472622
Recruiting
Early Phase 1
CD19/BCMA-Targeted UCAR-T for Patients With Neurological Autoimmune Diseases
Relapsing or Refractory Multiple Sclerosis (MS)Myasthenia Gravis (MG)Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)+1 more
Tongji Hospital36 enrolled1 locationNCT07337785
Recruiting
Early Phase 1
Concomitant Renal and Urinary Bladder Allograft Transplantation
Chronic Kidney DiseasesBladder DysfunctionNeurogenic Bladder+6 more
Mayo Clinic30 enrolled2 locationsNCT04626167
Recruiting
Early Phase 1
A Clinical Study Evaluating the Safety and Efficacy of GT801 Injection in Adult Patients With Relapsed/Refractory CD19-positive B-cell Hematologic Malignancies and Autoimmune Hemolytic Anemia
Chronic Lymphocytic Leukemia (CLL)B-cell Acute Lymphoblastic Leukemia (B-ALL)Autoimmune Hemolytic Anemia, AIHA+1 more
Grit Biotechnology28 enrolled2 locationsNCT07205315
Recruiting
Early Phase 1
Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis
Chronic Rhinosinusitis (Diagnosis)
University of Alabama at Birmingham20 enrolled1 locationNCT03439865
Recruiting
Early Phase 1
Safety and Efficacy of Mesenchymal Stem Cells Associated With Chronic Pancreatitis Pain
Chronic PainChronic Pancreatitis
Medical University of South Carolina48 enrolled1 locationNCT06205342
Recruiting
Early Phase 1
Cannabidiol in Opioid Use Disorder and Chronic Pain
Chronic PainOpioid-use Disorder
Yale University34 enrolled1 locationNCT04587791
Recruiting
Early Phase 1
EMG-guided Neuro-Intermuscular Coordination Enhancement (NICE) Rehabilitation Through Human-Machine Interaction
chronic strokeStrokeHemiparetic Stroke
University of Houston48 enrolled1 locationNCT07531264
Recruiting
Early Phase 1
Momelotinib in Combination With Hypomethylating Agent for Chronic Phase Myelodysplastic Syndromes/Myeloproliferative Overlap Neoplasms and Chronic Neutrophilic Leukemia
Myelodysplastic SyndromesChronic Myelomonocytic LeukemiaMyeloproliferative Overlap Neoplasms+1 more
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins18 enrolled1 locationNCT07071155
Recruiting
Early Phase 1
Treatment of Chronic Obstructive Pulmonary Disease (COPD) by REGEND007 Cell Therapy
Chronic Obstructive Pulmonary Disease (COPD)
Regend Therapeutics12 enrolled1 locationNCT07355868
Recruiting
Early Phase 1
Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib
Chronic Lymphocytic Leukemia (CLL)Small Lymphocytic Lymphoma (SLL)
National Heart, Lung, and Blood Institute (NHLBI)30 enrolled1 locationNCT07428707
Recruiting
Early Phase 1
Efficacy of Platelet-rich-Fibrin Gel in Patients With Chronic Leg Ulcers
Chronic Leg Ulcer
Pak Emirates Military Hospital40 enrolled1 locationNCT07294521
Recruiting
Early Phase 1
Human Amniotic-Derived Mesenchymal Stem Cell Therapy for Calciphylaxis
EfficacyTreatmentChronic Kidney Diseases+3 more
The First Affiliated Hospital with Nanjing Medical University9 enrolled1 locationNCT04592640
Recruiting
Early Phase 1
Simvastatin Treatment to Improve Patient-reported Outcomes in Patients With Chronic Pancreatitis
Chronic PancreatitisRecurrent Acute Pancreatitis
Cedars-Sinai Medical Center90 enrolled5 locationsNCT05771675
Recruiting
Early Phase 1
Feasibility Trial of Sodium-GLucose coTransporter 2 INhibitors in Pediatric Chronic KIDney DiSease
Chronic Kidney DiseasesPediatric Kidney Disease
Ann & Robert H Lurie Children's Hospital of Chicago40 enrolled1 locationNCT06430684
Recruiting
Early Phase 1
The Role of IL5 in Epithelial Cell Integrity
Chronic Rhinosinusitis With Nasal PolypsChronic Rhinosinusitis (Diagnosis)
Johns Hopkins University8 enrolled2 locationsNCT05895929
Recruiting
Early Phase 1
To Check Comparison of Apremilast and Methotrexate Efficacy in Patients With Moderate to Severe Plaque Psoriasis Presented to Tertiary Care Hospital
Chronic plaque psoriasis
Syeda Sana Zaman106 enrolled1 locationNCT07337434
Recruiting
Early Phase 1
Immunomodulatory Therapy and Predictors of Clinical Cure in Chronic Hepatitis B
Chronic Hepaititis B
Peking University People's Hospital132 enrolled1 locationNCT07328711
Recruiting
Early Phase 1
A Study on the Changes of Glucose Metabolism and Exocrine Function in Patients With Chronic Pancreatitis
Chronic Pancreatitis Pancreatic Exocrine Insufficiency Blood Glucose
Shanghai Changzheng Hospital80 enrolled2 locationsNCT07314489
Recruiting
Early Phase 1
Universal Chimeric Antigen Receptor T-Cell （UCAR T-cell） Therapy Targeting CD19/B Cell Maturation Antigen （CD19/BCMA） in Patients With r/r Neurological Autoimmune Diseases
Myasthenia GravisAutoimmune EncephalitisMultiple Sclerosis+2 more
Tianjin Huanhu Hospital12 enrolled1 locationNCT06939166