Early Phase 1 Chronic Clinical Trials
41 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 41 trials
Recruiting
Early Phase 1
Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib
Chronic Lymphocytic Leukemia (CLL)Small Lymphocytic Lymphoma (SLL)
National Heart, Lung, and Blood Institute (NHLBI)30 enrolled1 locationNCT07428707
Recruiting
Early Phase 1
A Clinical Study Evaluating the Safety and Efficacy of GT801 Injection in Adult Patients With Relapsed/Refractory CD19-positive B-cell Hematologic Malignancies and Autoimmune Hemolytic Anemia
Chronic Lymphocytic Leukemia (CLL)B-cell Acute Lymphoblastic Leukemia (B-ALL)Autoimmune Hemolytic Anemia, AIHA+1 more
Grit Biotechnology28 enrolled2 locationsNCT07205315
Recruiting
Early Phase 1
The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain.
Opioid-Refractory Chronic Cancer-Related Pain
National and Kapodistrian University of Athens24 enrolled1 locationNCT07408193
Recruiting
Early Phase 1
Evaluation of the Effectiveness and Safety of Mesotherapy in the Treatment of Chronic Low Back Pain Syndrome
Chronic Low Back Pain (Non-specific, Uncomplicated)
National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland90 enrolled1 locationNCT07675304
Recruiting
Early Phase 1
64Cu-LLP2A for Imaging Hematologic Malignancies
Chronic Lymphocytic LeukemiaMultiple MyelomaFollicular Lymphoma+4 more
Washington University School of Medicine42 enrolled1 locationNCT06636175
Recruiting
Early Phase 1
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CTX001 in Healthy Adults.
Chronic Kidney DiseaseIron DeficienciesAnemia
Cajal Therapeutics Inc.72 enrolled1 locationNCT07577817
Recruiting
Early Phase 1
Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant
Acute Myeloid LeukemiaMyelodysplastic SyndromesChronic Myelomonocytic Leukemia+4 more
Omar Aljitawi24 enrolled1 locationNCT03964506
Recruiting
Early Phase 1
Brain Mechanisms Supporting Cannabis-induced Pain Relief
Chronic Low Back Pain (CLBP)SciaticaLumbar Radiculopathy+4 more
University of California, San Diego100 enrolled1 locationNCT04982965
Recruiting
Early Phase 1
Functional Neuroimaging to Detect the Neural Signatures of the Unpleasantness of Pain and Effort
Fatigue Syndrome, Chronic
National Institute of Neurological Disorders and Stroke (NINDS)47 enrolled1 locationNCT06472622
Recruiting
Early Phase 1
CD19/BCMA-Targeted UCAR-T for Patients With Neurological Autoimmune Diseases
Relapsing or Refractory Multiple Sclerosis (MS)Myasthenia Gravis (MG)Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)+1 more
Tongji Hospital36 enrolled1 locationNCT07337785
Recruiting
Early Phase 1
Concomitant Renal and Urinary Bladder Allograft Transplantation
Chronic Kidney DiseasesBladder DysfunctionNeurogenic Bladder+6 more
Mayo Clinic30 enrolled2 locationsNCT04626167
Recruiting
Early Phase 1
Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis
Chronic Rhinosinusitis (Diagnosis)
University of Alabama at Birmingham20 enrolled1 locationNCT03439865
Recruiting
Early Phase 1
Safety and Efficacy of Mesenchymal Stem Cells Associated With Chronic Pancreatitis Pain
Chronic PainChronic Pancreatitis
Medical University of South Carolina48 enrolled1 locationNCT06205342
Recruiting
Early Phase 1
Cannabidiol in Opioid Use Disorder and Chronic Pain
Chronic PainOpioid-use Disorder
Yale University34 enrolled1 locationNCT04587791
Recruiting
Early Phase 1
EMG-guided Neuro-Intermuscular Coordination Enhancement (NICE) Rehabilitation Through Human-Machine Interaction
chronic strokeStrokeHemiparetic Stroke
University of Houston48 enrolled1 locationNCT07531264
Recruiting
Early Phase 1
Momelotinib in Combination With Hypomethylating Agent for Chronic Phase Myelodysplastic Syndromes/Myeloproliferative Overlap Neoplasms and Chronic Neutrophilic Leukemia
Myelodysplastic SyndromesChronic Myelomonocytic LeukemiaMyeloproliferative Overlap Neoplasms+1 more
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins18 enrolled1 locationNCT07071155
Recruiting
Early Phase 1
Treatment of Chronic Obstructive Pulmonary Disease (COPD) by REGEND007 Cell Therapy
Chronic Obstructive Pulmonary Disease (COPD)
Regend Therapeutics12 enrolled1 locationNCT07355868
Recruiting
Early Phase 1
Efficacy of Platelet-rich-Fibrin Gel in Patients With Chronic Leg Ulcers
Chronic Leg Ulcer
Pak Emirates Military Hospital40 enrolled1 locationNCT07294521
Recruiting
Early Phase 1
Human Amniotic-Derived Mesenchymal Stem Cell Therapy for Calciphylaxis
EfficacyTreatmentChronic Kidney Diseases+3 more
The First Affiliated Hospital with Nanjing Medical University9 enrolled1 locationNCT04592640
Recruiting
Early Phase 1
Simvastatin Treatment to Improve Patient-reported Outcomes in Patients With Chronic Pancreatitis
Chronic PancreatitisRecurrent Acute Pancreatitis
Cedars-Sinai Medical Center90 enrolled5 locationsNCT05771675