Phase 1 Cognitive Clinical Trials
29 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 29 trials
Recruiting
Phase 1
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
HealthyMild Cognitive ImpairmentAlzheimer s Disease
National Institute of Mental Health (NIMH)90 enrolled1 locationNCT07169630
Recruiting
Phase 1
Safety And Tolerability Of Gamma Glutamylcysteine (GGC) Oral Supplementation In MCI Patients
Mild Cognitive Impairment (MCI)
Pravat Mandal9 enrolled1 locationNCT07583251
Recruiting
Phase 1
TREAD: Time Restricted Eating Intervention for Alzheimer's Disease
Alzheimer DiseaseMild Cognitive ImpairmentAlzheimer s Disease
University of California, San Diego60 enrolled1 locationNCT06548191
Recruiting
Phase 1
PET Imaging of Cyclooxygenases in Neurodegenerative Brain Disease
DementiaALSMild Cognitive Impairment+2 more
National Institute of Mental Health (NIMH)184 enrolled1 locationNCT04396873
Recruiting
Phase 1
Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease
Cognitive ImpairmentSickle Cell DiseaseAttention Deficit Hyperactivity Disorder (ADHD)+1 more
St. Jude Children's Research Hospital72 enrolled1 locationNCT07226219
Recruiting
Phase 1Phase 2
FACE Phase II (a Stage II Trial)
MCIMild Behavioral ImpairmentSubjective Cognitive Decline (SCD)
Stanford University80 enrolled1 locationNCT07130669
Recruiting
Phase 1Phase 2
rTMS to Improve Cognition in Parkinson's
Mild Cognitive ImpairmentParkinson's Disease
VA Office of Research and Development56 enrolled2 locationsNCT03836950
Recruiting
Phase 1Phase 2
Stem Cell Therapy for Early Alzheimer's Disease
Cognitive Dysfunction
Paul E Schulz12 enrolled1 locationNCT06775964
Recruiting
Phase 1Phase 2
Sense4Safety Intervention
Mild Cognitive Impairment
University of Pennsylvania200 enrolled1 locationNCT07220668
Recruiting
Phase 1Phase 2
The Efficacy and Safety of Metformin Intervention in Elderly Overweight or Obesity With Mild Cognitive Impairment
ElderlyMild Cognitive ImpairmentOverweight or Obesity
Fudan University54 enrolled1 locationNCT07395960
Recruiting
Phase 1Phase 2
Modafinil to Improve Fatiguability
Cancer-related Cognitive DifficultiesFatigueCancer-related Problem/Condition
Ottawa Hospital Research Institute40 enrolled1 locationNCT05333250
Recruiting
Phase 1Phase 2
Living Independence Through Functional Training
Cognitive ImpairmentMobility Limitation
University of Florida10 enrolled2 locationsNCT07125378
Recruiting
Phase 1
Innate Immunity Stimulation Via TLR9 in Early AD
Mild Cognitive ImpairmentAlzheimer Dementia
NYU Langone Health18 enrolled1 locationNCT05606341
Recruiting
Phase 1Phase 2
RAGE Inhibition to Decrease Cardiotoxicity in Women With Early Breast Cancer
Cancer Related Cognitive DeclineNon-metastatic Breast Cancer
Georgetown University48 enrolled3 locationsNCT05256745
Not Yet Recruiting
Phase 1
The MENOCOG Trial: Feasibility, acceptability, and safety of creatine monohydrate supplementation for cognitive function and mood in postmenopausal females with subjective cognitive decline: a randomised, double-blind, placebo-controlled, parallel-group trial
PostmenopauseSubjective Cognitive Decline
Western Sydney University86 enrolled1 locationACTRN12625001344482
Recruiting
Phase 1
Door-Through-Door Companion Rideshare Technology for Individuals With Alzheimer's Disease and Related Dementias (AD/ADRD)
DementiaCognitive DeclineAlzheimer Disease or Associated Disorder
Onward Health, Inc120 enrolled1 locationNCT06850870
Recruiting
Phase 1
A Clinical Trial of AAV2-BDNF Gene Therapy in Early Alzheimer's Disease and Mild Cognitive Impairment
Mild Cognitive ImpairmentAlzheimer s Disease
Mark Tuszynski12 enrolled2 locationsNCT05040217
Recruiting
Phase 1
Safety Of Nrtis for Alzheimer's Therapeutic Advancement in Singapore Study
Mild Cognitive Impairment (MCI)Alzheimer Dementia (AD)
National University Hospital, Singapore48 enrolled1 locationNCT07210528
Recruiting
Phase 1Phase 2
SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During Antiretroviral Therapy
HealthyHIV Associated Neurocognitive DisorderHIV Dementia+1 more
Yale University70 enrolled1 locationNCT05586581
Recruiting
Phase 1
Study of Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of NIO752 in Early Alzheimer's Disease Participants
Alzheimer DiseaseMild Cognitive Impairment
Novartis Pharmaceuticals36 enrolled10 locationsNCT05469360