Cognitive Clinical Trials

930 recruitingLast updated: June 17, 2026

There are 930 actively recruiting cognitive clinical trials across 64 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4, Early Phase 1. Top locations include Boston, Massachusetts, United States, Toronto, Ontario, Canada, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Cognitive Trials at a Glance

930 actively recruiting trials for cognitive are listed on ClinicalTrialsFinder across 6 cities in 64 countries. The largest study group is Not Applicable with 524 trials, with the heaviest enrollment activity in Boston, Toronto, and New York. Lead sponsors running cognitive studies include Massachusetts General Hospital, Johns Hopkins University, and Riphah International University.

Treatments under study

About Cognitive Clinical Trials

Looking for clinical trials for Cognitive? There are currently 2 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Cognitive trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Cognitive clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 930 trials

Recruiting
Phase 1

PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)

HealthyMild Cognitive ImpairmentAlzheimer s Disease
National Institute of Mental Health (NIMH)90 enrolled1 locationNCT07169630
Recruiting
Not Applicable

e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most

DementiaMild Cognitive Impairment (MCI)Potentially Inappropriate Medication Use
Johns Hopkins University100 enrolled1 locationNCT07454824
Recruiting
Phase 2

Neurotransmitters in Treatment Resistant Schizophrenia Patients With add-on Sodium Benzoate

SchizophreniaSchizo Affective DisorderSymptom, Cognitive
National Cheng-Kung University Hospital90 enrolled1 locationNCT06340789
Recruiting
Phase 2

Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV

Mild Neurocognitive DisorderMajor Depressive DisorderHIV
National Institute of Allergy and Infectious Diseases (NIAID)186 enrolled41 locationsNCT06705478
Recruiting
Not Applicable

Breast Cancer, Reasoning, and Activity Intervention

Breast CancerBreast NeoplasmsAnatomic Stage II Breast Cancer AJCC v8+3 more
Mayo Clinic160 enrolled1 locationNCT04816006
Recruiting
Phase 2

CBD for Individuals at Risk for Alzheimer's Disease

Mild Cognitive Impairment
University of Colorado, Denver236 enrolled1 locationNCT05822362
Recruiting

POCD After Major Gynecologic Surgery

Postoperative Cognitive DysfunctionPerioperative Neurocognitive Disorder
Fatihhan Zeytun72 enrolled1 locationNCT07589348
Recruiting
Not Applicable

Music for Pain and Dementia

DementiaCaregiverAlzheimer Disease+2 more
Yale University60 enrolled1 locationNCT07602283
Recruiting
Not Applicable

Evaluating Health Outcomes of AI-Based Fitness Wearables and App Programs in Older Adults Living Alone With Cognitive Decline

Older AdultsPhysical InactivityPhysical Activity+4 more
The University of Tennessee, Knoxville64 enrolled2 locationsNCT07207993
Recruiting
Not Applicable

Using Light Therapy for Mild Cognitive Impairment

Mild Cognitive Impairment (MCI)Amyloid Pathology
University of Oklahoma40 enrolled1 locationNCT07651787
Recruiting
Not Applicable

The Cognitive Protective Effect of VR-based Cognitive Training in Type 2 Diabetes Patients With Mild Cognitive Impairment

Type 2 Diabetes Mellitus (T2DM)Mild Cognitive Impairment (MCI)
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School40 enrolled1 locationNCT07650318
Recruiting
Phase 2

UCSD Image-Guided Cognitive-Sparing Radiosurgery for Brain Metastases

CancerBrain Metastases, AdultNeurocognitive Function
Jona Hattangadi-Gluth60 enrolled1 locationNCT04343157
Recruiting
Not Applicable

Polyphenols and Cognitive Decline

Cognitive DysfunctionCognitive Decline
University of California, Los Angeles300 enrolled1 locationNCT06507254
Recruiting

Human Observatory Study

Musculoskeletal DiseaseDisability PhysicalNeoplasms+16 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07646782
Recruiting
Not Applicable

Community-Based Social Connection Intervention Program to Improve Cardiovascular and Brain Health

Cognitive DeclineStrokeLoneliness+1 more
Universidad de Especialidades Espiritu Santo500 enrolled1 locationNCT07319663
Recruiting
Not Applicable

Exercise Adherence and Cognitive Decline: Phase 2

Cognitive Decline
University of Colorado, Boulder226 enrolled2 locationsNCT07127965
Recruiting

100-Year Human Aging Study

Disability PhysicalNeoplasmsCardiovascular Diseases+12 more
Longevity Metrics, Inc.1,000,000 enrolled1 locationNCT07563777
Recruiting
Not Applicable

Temporal Interference Stimulation Treatment in Patients With Cognitive Impairment

FTDAD - Alzheimer's DiseaseAD-MCI+1 more
Tianjin Huanhu Hospital60 enrolled1 locationNCT07643363
Recruiting
Not Applicable

Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

DementiaAlzheimer DiseaseCommunication Disorders+11 more
Stephanie Grasso60 enrolled3 locationsNCT05741853
Recruiting

Impact of Targeted Therapy on Cancer-Related Cognitive Impairment

Chronic Lymphocytic Leukemia (CLL)Chronic Myeloid Leukemia, BCR-ABL1 PositiveDisease/Condition Name Cancer-related Cognitive Dysfunction
University of Rochester NCORP Research Base400 enrolled1 locationNCT07638007