Decompensated Heart Failure Clinical Trials

9 recruiting

Decompensated Heart Failure Trials at a Glance

31 actively recruiting trials for decompensated heart failure are listed on ClinicalTrialsFinder across 6 cities in 19 countries. The largest study group is Not Applicable with 12 trials, with the heaviest enrollment activity in Oklahoma City, Cairo, and Atlanta. Lead sponsors running decompensated heart failure studies include Reprieve Cardiovascular, Inc, Universitas Diponegoro, and Biotronik SE & Co. KG.

Browse decompensated heart failure trials by phase

Treatments under study

About Decompensated Heart Failure Clinical Trials

Looking for clinical trials for Decompensated Heart Failure? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Decompensated Heart Failure trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Decompensated Heart Failure clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 31 trials

Recruiting
Not Applicable

Cardiac Rehabilitation in Decompensated Heart Failure

Decompensated Heart Failure
Beni-Suef University135 enrolled1 locationNCT07506499
Recruiting
Phase 3

Effects of Continued Administration of Empagliflozin in Patients With Heart Failure on Active SGLT2 Inhibitor Treatment Admitted for Acute Decompensated Heart Failure

Acute Decompensated Heart Failure (ADHF)
Christian Schulze536 enrolled9 locationsNCT07038356
Recruiting

Characterisation of phenotYpes in aCute Heart faiLure patiEnts

Cardiogenic ShockAcute Heart FailureDecompensated Heart Failure
Universitätsklinikum Hamburg-Eppendorf1,000 enrolled1 locationNCT07508891
Recruiting
Phase 1

Vericiguat in Decompensated Cardiac Failure: Clinical Insights on Addition to Guidelines Derived Medical Therapy-VERCIG Trial

Decompensated Heart Failure
Khawaja Danish Ali130 enrolled1 locationNCT07444398
Recruiting
Not Applicable

Reprieve System Pilot Study

Acute Decompensated Heart Failure
Reprieve Cardiovascular, Inc50 enrolled1 locationNCT06272734
Recruiting
Phase 2

Add-on Diuretics in Acute Decompensated Heart Failure

Acute Decompensated Heart Failure
Tanta University66 enrolled1 locationNCT07372040
Recruiting
Not Applicable

Use of Point-of-Care Ultrasound (POCUS) to Reduce Hospital Length of Stay in Patients With Heart Failure ( POCUSHF )

Heart FailureDecompensated Heart FailureHospital Length of Stay
Florida International University66 enrolled1 locationNCT06965712
Recruiting
Phase 3

Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)

Acute Decompensated Heart Failure
Reprieve Cardiovascular, Inc400 enrolled53 locationsNCT06898515
Recruiting
Not Applicable

Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patients With Acute Decompensated Heart Failure

Heart Failure, DiastolicAcute Decompensated Heart FailureHeart Failure, Systolic
University of Health Sciences Lahore320 enrolled1 locationNCT07199088
Recruiting
Not Applicable

Bioimpedance Integration for Optimized Fluid Management in Decompensated Heart Failure

Heart FailureDecompensated Heart Failure
Mid and South Essex NHS Foundation Trust255 enrolled1 locationNCT07173426
Recruiting
Not Applicable

BIO|CONCEPT.BIOMONITOR-HF Collect Clinical Data From Heart Failure Patients Using BIOMONITOR Devices With a Study Specific Research Software

Heart FailureAtrial FibrillationArrhythmia+1 more
Biotronik SE & Co. KG300 enrolled2 locationsNCT06989580
Recruiting
Phase 4

The Effect of Dapagliflozin on Patients With Cardiomyopathy

Acute Decompensated Heart Failure (ADHF)
May Mohamed Abdalla100 enrolled1 locationNCT07076615
Recruiting
Not Applicable

EACH-ADHF: Early Comprehensive Rehabilitation in Patients With ADHF

Acute Decompensated Heart Failure
Guangdong Provincial People's Hospital140 enrolled1 locationNCT06161987
Recruiting

Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure

Heart FailureAcute Decompensated Heart Failure
UConn Health500 enrolled1 locationNCT00762008
Recruiting
Not Applicable

Using an Intervention Adapted to the Health Literacy Level to Improve Adherence to Medical Recommendations

Acute Myocardial InfarctionAcute Decompensated Heart Failure
Hospices Civils de Lyon300 enrolled4 locationsNCT03951467
Recruiting
Not Applicable

Low Level Tragus Stimulation in Acute Decompensated Heart Failure

Acute Decompensated Heart Failure
University of Oklahoma100 enrolled1 locationNCT02898181
Recruiting
Not Applicable

Safety and Performance Evaluation of the Nephronyx System for the Treatment of Patients With ADHF

Acute Decompensated Heart Failure
Nephronyx LTD10 enrolled4 locationsNCT05759806
Recruiting

Change in Stroke Volume Index After Diuresis for Patients With Decompensated Heart Failure

Acute Decompensated Heart Failure
NYU Langone Health50 enrolled1 locationNCT05240651
Recruiting

A Prospective, Observational, Single Centre Study to Assess the Feasibility of the Data Harvested by the Acorai Intracardiac Pressure Monitoring (ICPM) System in Predicting Prognosis in Patients Discharged From Hospital After Treatment for Acute Decompensated Heart Failure

Heart FailureDecompensated Heart Failure
Royal Brompton & Harefield NHS Foundation Trust150 enrolled1 locationNCT06397833
Recruiting
Not Applicable

Venous Ultrasound Guided Organ Decongestion in Patients Hospitalized with Acute Decompensated Heart Failure

Heart FailureAcute Kidney InjuryAcute Decompensated Heart Failure+1 more
Oslo University Hospital180 enrolled1 locationNCT06714409