Degeneration Clinical Trials

1 recruiting

Frequently Asked Questions

Common questions about Degeneration clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 193 trials

Recruiting
Phase 3

Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)

Neovascular Age-related Macular Degeneration
AbbVie561 enrolled95 locationsNCT07007065
Recruiting

Rod and Cone Mediated Function in Retinal Disease

Stargardt's DiseaseRetinal DegenerationRetinitis Pigmentosa
National Eye Institute (NEI)500 enrolled1 locationNCT02617966
Recruiting
Phase 1

Kisspeptin to Quantify GnRH Neuronal Function in Health and Disease

NeurodegenerationReproductive Disorder
Stephanie B. Seminara, MD40 enrolled1 locationNCT07224490
Recruiting
Phase 1

Virtual Reality Mobility Assessment of Functional Vision in Retinal Disease

Cone-Rod DegenerationRod-Cone Degeneration
National Eye Institute (NEI)165 enrolled2 locationsNCT04289571
Recruiting

Cell Collection to Study Eye Diseases

Retinal DegenerationRetinitis PigmentosaRetinal Disease+1 more
National Eye Institute (NEI)930 enrolled1 locationNCT01432847
Recruiting

National Eye Institute Biorepository for Retinal Diseases

Age-Related Macular DegenerationDiabetic RetinopathyRetinal Disease+2 more
National Eye Institute (NEI)650 enrolled1 locationNCT01496625
Recruiting
Phase 2

MMP-9 Inhibition for Recalcitrant Wet AMD

Exudative Macular Degeneration
University of Iowa50 enrolled1 locationNCT04504123
Recruiting
Phase 3

A Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMD

Neovascular Age-related Macular Degeneration
Hoffmann-La Roche250 enrolled53 locationsNCT06847542
Recruiting
Not Applicable

Spatiotemporal Entrainment Neuromodulation Targeting Cerebello-Cerebral Circuits to Enhance Cognitive and Social Rehabilitation in Cerebellar Diseases

Cerebellar DegenerationCerebellar Malformation
I.R.C.C.S. Fondazione Santa Lucia60 enrolled2 locationsNCT07500103
Recruiting

Age-Related Macular Degeneration Benchmark Imaging Dataset (ABID)

Age-Related Macular Degeneration
University of Wisconsin, Madison1,000 enrolled14 locationsNCT06924021
Recruiting

Adherence to Home-Based Exercises in Musculoskeletal Disorders

Musculoskeletal DiseaseExercise TrainingStroke+6 more
Konya Beyhekim Training and Research Hospital252 enrolled1 locationNCT07261553
Recruiting

Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery

Lumbar Spinal StenosisLumbar Disc Herniation With RadiculopathyLumbar Degenerative Spondylolisthesis+1 more
Marmara University75 enrolled1 locationNCT07489001
Recruiting

Clariance ErYs Registry

Spinal TumorSpinal DeformitySpine Degeneration+2 more
Clariance760 enrolled1 locationNCT05170815
Recruiting
Not Applicable

Direct Discrimination of Quantum States by the Human Eye

Age-Related Macular Degeneration
Centre for Eye and Vision Research50 enrolled1 locationNCT05913063
Recruiting
Phase 3

Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS)

Neovascular Age-Related Macular Degeneration (nAMD)Wet AMD
Adverum Biotechnologies, Inc.284 enrolled2 locationsNCT07482176
Recruiting
Phase 4

A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)

Neovascular Age-related Macular Degeneration
Genentech, Inc.188 enrolled50 locationsNCT04853251
Recruiting
Phase 2

A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

Geographic AtrophyMacular Degeneration
Janssen Research & Development, LLC274 enrolled104 locationsNCT06635148
Recruiting

A Real-World Study to Gain Clinical Insights Into Faricimab (FaReal Study)

Neovascular Age-related Macular DegenerationDiabetic Macular Edema
Hoffmann-La Roche850 enrolled55 locationsNCT06680817
Recruiting
Early Phase 1

Safety and Efficacy Evaluation of LX111 Gene Therapy in nAMD Patients

Neovascular Age-related Macular Degeneration
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine10 enrolled1 locationNCT07053358
Recruiting

Real-World Evaluation of AI Enabled Multi-Spectral Imaging (MSI) for AMD Biomarker Detection

Age-Related (Dry) Macular Degeneration
AI-Spectral1,000 enrolled1 locationNCT07446582