Spinal Stenosis Clinical Trials

70 recruitingLast updated: May 21, 2026

There are 70 actively recruiting spinal stenosis clinical trials across 23 countries. Studies span Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 1, Phase 2. Top locations include New York, New York, United States, Aurora, Colorado, United States, Beijing, Beijing Municipality, China. Updated daily from ClinicalTrials.gov.


Spinal Stenosis Trials at a Glance

70 actively recruiting trials for spinal stenosis are listed on ClinicalTrialsFinder across 6 cities in 23 countries. The largest study group is Not Applicable with 30 trials, with the heaviest enrollment activity in New York, Aurora, and Beijing. Lead sponsors running spinal stenosis studies include Hospital for Special Surgery, New York, Peking University Third Hospital, and Xijing Hospital.

Browse spinal stenosis trials by phase

About Spinal Stenosis Clinical Trials

Looking for clinical trials for Spinal Stenosis? There are currently 19 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Spinal Stenosis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Spinal Stenosis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 70 trials

Recruiting

MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study

Lumbar Spinal Stenosis
Stryker Instruments8,000 enrolled2284 locationsNCT03072927
Recruiting
Not Applicable

Comparative Analysis of Two Transforaminal Lumbar Interbody Fusion (TLIF) Procedures in the Treatment of Single-Level Lumbar Spinal Stenosis (LSS): A Single-Center, Prospective, Randomized Controlled Trial

Lumbar Spinal Stenosis
The Third Affiliated Hospital of Southern Medical University276 enrolled1 locationNCT07588555
Recruiting
Phase 4

Efficacy of M640 in Acute Lumbosacral Musculoskeletal Conditions.

Lumbar Spinal StenosisSciatica Acute
Primus Pharmaceuticals50 enrolled24 locationsNCT06157177
Recruiting

OssDsign® Spine Registry Study ("Propel")

Spinal StenosisDegenerative Disc Disease
OssDsign450 enrolled15 locationsNCT05329129
Recruiting
Phase 3

Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression

Opioid UsePain, PostoperativePain, Back+1 more
Hospital for Special Surgery, New York150 enrolled1 locationNCT05058287
Recruiting
Phase 3

Tranexamic Acid in Adult Spinal Deformity Surgery

Blood Loss, SurgicalSpinal DeformityDegenerative Lumbar Spinal Stenosis
Hospital for Special Surgery, New York100 enrolled1 locationNCT03553186
Recruiting
Not Applicable

Evaluation of a Digital Person-Centered Rehabilitation Program Targeting Physical Activity in Spinal Stenosis Surgery (Get Back)

Spinal Stenosis Lumbar
Sophiahemmet University252 enrolled4 locationsNCT06935201
Recruiting
Early Phase 1

Study Comparing Local/ MAC Anesthesia in Lumbar Decompression

Lumbar Spinal Stenosis
Stanford University100 enrolled2 locationsNCT04992572
Recruiting

Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery

Lumbar Spinal StenosisLumbar Disc Herniation With RadiculopathyLumbar Degenerative Spondylolisthesis+1 more
Marmara University75 enrolled1 locationNCT07489001
Recruiting

Presence of Dural Pulsation in Patients Diagnosed With Lumbar Spinal Stenosis

ClaudicationDisability PhysicalMagnetic Resonance+2 more
Marmara University100 enrolled1 locationNCT07233798
Recruiting

Bilateral Lumbar Decompression Via Uniportal Endoscopic Laminotomy in Patients With Lumbar Spinal Stenosis: Multicentric Case Series

Spinal Stenosis Lumbar
TecSalud Investigación Clínica78 enrolled1 locationNCT07045714
Recruiting

Multicentric Case Series of Uniportal Endoscopic Posterior Cervical Decompression for Cervical Spinal Stenosis

Spinal Stenosis Cervical
TecSalud Investigación Clínica50 enrolled1 locationNCT06886802
Recruiting
Phase 1

Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury

Spinal StenosisDegenerative Disc DiseaseSpinal Cord Injuries+2 more
EicOsis Human Health Inc.36 enrolled1 locationNCT06438471
Recruiting
Phase 4

Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery

Lumbar RadiculopathyDegenerative Disc DiseaseLumbar Spinal Stenosis+7 more
John O'Toole125 enrolled1 locationNCT05029726
Recruiting
Not Applicable

Comparison of the Postoperative Analgesic Efficacy of Classical and Modified Erector Spinae Plane Blocks After Lumbar Spinal Surgery

Acute PainSpinal Stenosis Lumbar
Samsun University60 enrolled1 locationNCT07348523
Recruiting
Not Applicable

Quadro-Iliac vs Thoracolumbar Interfascial Plane Block for Analgesia After Single-Level Lumbar Disc Surgery

Spinal StenosisAcute Pain
Samsun University70 enrolled1 locationNCT07348419
Recruiting
Not Applicable

Necessity of Fusion Following Decompression Surgery in Patients With Single-level Lumbar Stenosis

Spinal StenosisLumbar Spinal StenosisSpinal Fusion
Sklifosovsky Institute of Emergency Care86 enrolled2 locationsNCT05273879
Recruiting

Functional and Structural Changes in the Central Nervous System Following Spinal Cord Injury

Spinal Cord InjuriesNeurogenic Bladder DysfunctionDegenerative Cervical Spinal Stenosis
University of Zurich225 enrolled1 locationNCT05681936
Recruiting
Not Applicable

Lumbosacral Spinal Stenosis - Non-Invasive Postural Therapy for Older Adult Veterans

Lumbar Spinal Stenosis
VA Office of Research and Development20 enrolled1 locationNCT06089746
Recruiting
Early Phase 1

Decompressive Laminectomy Versus Laminectomy With Transpedicular Fixation in Lumbar Spinal Stenosis

Lumbar Spinal Stenosis
Punjab Health Care Commission60 enrolled1 locationNCT07281625