Disc Degeneration Clinical Trials

20 recruitingLast updated: June 18, 2026

There are 20 actively recruiting disc degeneration clinical trials across 14 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 1. Top locations include Bruges, France, Brno, Czechia, Broadmeadow, New South Wales, Australia. Updated daily from ClinicalTrials.gov.


Disc Degeneration Trials at a Glance

20 actively recruiting trials for disc degeneration are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 7 trials, with the heaviest enrollment activity in Bruges, Brno, and Broadmeadow. Lead sponsors running disc degeneration studies include SPINEVISION SAS, VIVEX Biologics, Inc., and Copernicus Memorial Hospital.

Browse disc degeneration trials by phase

Treatments under study

About Disc Degeneration Clinical Trials

Looking for clinical trials for Disc Degeneration? There are currently 5 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Disc Degeneration trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Disc Degeneration clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 20 trials

Recruiting

Real World Data Collection on the Synergy Cervical Disc

Cervical disc degeneration
Synergy Spine Solutions200 enrolled1 locationNCT05305430
Recruiting
Not Applicable

Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease

Degenerative Disc DiseaseDisc DegenerationLumbar Discogenic Pain
VIVEX Biologics, Inc.496 enrolled19 locationsNCT06778447
Recruiting
Not Applicable

Comparison of Clinical Outcomes, Complications Rate and Treatment Costs of Mini-TLIF and MIDLIF in the Treatment of Discogenic Low Back Pain

Lumbar Disc DegenerationDegenerative Disc Disease (DDD)Lumbar Degenerative Disease+1 more
Copernicus Memorial Hospital100 enrolled1 locationNCT07127380
Recruiting
Phase 1Phase 2

EvaluatIon of Autologous Nucleus Pulposus Cells (aNPC) in Degenerative Disc Disease

Intervertebral disc degeneration
ASTEROGENE Biomedical Co. Ltd.12 enrolled1 locationNCT07168603
Recruiting

Opioid Free and Opioid Based Anesthesia in Elective Lumbar Spine Surgery

Lumbar Spinal StenosisLumbar Disc Herniation With RadiculopathyLumbar Degenerative Spondylolisthesis+1 more
Marmara University75 enrolled1 locationNCT07489001
Recruiting

Safety and Performance of the Hexanium TLIF System in the Treatment of Degenerative Disc Disease

Intervertebral disc degeneration
SPINEVISION SAS187 enrolled6 locationsNCT05997121
Recruiting

Safety and Performance of the SpineVision Posterior Fixation Systems in Thoracolumbar Spinal Treatment

Intervertebral disc degeneration
SPINEVISION SAS330 enrolled3 locationsNCT06342765
Recruiting
Not Applicable

Comparaison of Interbody Bone Fusion Between Two Osteoinductive Bioactive Bone Substitutes After Anterior Lumbar Interbody Arthrodesis in Degenerative Lumbar Disc Surgery in Adults

Disc Degeneration
University Hospital, Montpellier100 enrolled1 locationNCT07044206
Recruiting
Not Applicable

Cervical Movement Control Before and After Anterior Cervical Discectomy and Fusion

intervertebral disc displacementCervical Vertebral Disc Degeneration
University of Ljubljana30 enrolled1 locationNCT07425613
Recruiting
Phase 4

Efficacy and Safety of Preemptive Intravenous Dexamethasone in MIS-TLIF

SurgeryDisc DegenerationDisc Disease+2 more
Potsawat Surabotsopon60 enrolled1 locationNCT06367855
Recruiting

The Role of Cutibacterium Acnes in the Development of Degenerative Lumbar Intervertebral Disc Disease

Low Back PainLumbar Disc HerniationLumbar Disc Degeneration+1 more
Masaryk University400 enrolled1 locationNCT07085247
Recruiting
Phase 2

Efficacy of Intradiscal Injection of Autologous BM-MSC in Subjects With Chronic LBP Due to Multilevel Lumbar IDD

Intervertebral disc degenerationChronic Low-back Pain
Fondazione Policlinico Universitario Campus Bio-Medico52 enrolled1 locationNCT05066334
Recruiting

Total Lumbar Disc Prosthesis and Subsequent Work Activity at at Least Five Years After Total Lumbar Disc Replacement

SciaticaLumbar Disc HerniationLumbar Disc Degeneration+2 more
University of Valencia150 enrolled1 locationNCT06989632
Recruiting
Not Applicable

Pilot Study of ZetaFuse™ Bone Graft for the Treatment of Cervical Degenerative Disc Disease

Disc DegenerationDisc DiseaseNeurological Abnormality+2 more
Zetagen Therapeutics, Inc10 enrolled2 locationsNCT05971329
Recruiting

A Post Market Surveillance on INFUSE Bone Graft

Intervertebral disc degenerationSpinal FusionLumbar Disc Disease
Medtronic Spinal and Biologics600 enrolled1 locationNCT05299762
Recruiting
Phase 2

ASCEND: A Clinical Trial to Evaluate the Safety and Effectiveness of VIA Disc NP, a Supplement for Degenerated Intervertebral Discs

Degenerative Disc DiseaseDisc DegenerationLumbar Discogenic Pain
VIVEX Biologics, Inc.110 enrolled5 locationsNCT06615505
Recruiting

Intraoperative Monitoring for the Lateral Lumbar Interbody Fusion Procedure

Intervertebral disc degenerationSpondylolisthesisSpinal Instability+2 more
Alphatec Spine, Inc.400 enrolled1 locationNCT05648474
Recruiting
Phase 4

Comparison of Rigid and Non-Rigid Interbody Fusion Device for Cervical Degenerative Disc Disease in Adults

Cervical disc degeneration
National Taiwan University Hospital180 enrolled13 locationsNCT04550923
Recruiting
Not Applicable

Cervical Arthroplasty Cost Effectiveness Study (CACES)

Cervical disc degenerationCervical SpondylosisCervical Disc Herniation+16 more
Valérie Schuermans198 enrolled1 locationNCT04623593
Recruiting
Not Applicable

Open Access Database of Standing Full Body Radiographs in Asymptomatic Volunteers

Intervertebral disc degenerationOsteoarthritis, Spine
University of Colorado, Denver60 enrolled1 locationNCT03076658