Phase 1 Disease Clinical Trials
592 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 592 trials
Recruiting
Phase 1
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
HealthyMild Cognitive ImpairmentAlzheimer s Disease
National Institute of Mental Health (NIMH)90 enrolled1 locationNCT07169630
Recruiting
Phase 1
Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell Disease
Sickle Cell Disease, Hemolytic Anemia
National Heart, Lung, and Blood Institute (NHLBI)25 enrolled1 locationNCT07566494
Recruiting
Phase 1
A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease
Alzheimer s Disease
Alnylam Pharmaceuticals50 enrolled13 locationsNCT07214727
Recruiting
Phase 1
A Phase I Study in Healthy Volunteers and Parkinson's Disease (PD) Patients.
Early-stage Parkinson’s diseaseParkinson's Disease (PD)Mild to Moderate Parkinson's Disease
Mission Therapeutics106 enrolled18 locationsNCT07630545
Recruiting
Phase 1
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
HypercholesterolaemiaMetabolic DiseaseDyslipidemias+7 more
CRISPR Therapeutics AG90 enrolled19 locationsNCT07491172
Recruiting
Phase 1
Diagnosis of Pheochromocytoma
PheochromocytomaEndocrine DiseaseEndocrine Diseases
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)3,000 enrolled1 locationNCT00004847
Recruiting
Phase 1
Ex Vivo-Expanded Regulatory T Cells Plus Low-Dose Interleukin-2 for Steroid-Refractory Chronic GVHD
Graft Versus Host Disease (cGvHD)
Leslie Kean21 enrolled1 locationNCT06991361
Recruiting
Phase 1
TMLI and Alemtuzumab for Treatment of Sickle Cell Disease
Sickle Cell Disease
City of Hope Medical Center20 enrolled1 locationNCT05384756
Recruiting
Phase 1
A Study of BBT002 in Healthy Volunteers (HVs) and in Patients With Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease (COPD)
Bambusa Therapeutics68 enrolled11 locationsNCT07288554
Recruiting
Phase 1
AV-1980R (Tau Vaccine) in Preclinical Alzheimer's Disease (TAURUS-1980)
Alzheimer DiseasePreclinical Alzheimer's Disease
Institute for Molecular Medicine48 enrolled5 locationsNCT07158905
Recruiting
Phase 1Phase 2
Study to Evaluate the Safety and Effectiveness of Withaferin A as a Treatment to Prevent GvHD in Transplant Patients
Hematopoietic Stem Cell Transplant (HSCT)Hematological MalignancyGVHD - Graft-Versus-Host Disease
Tata Memorial Centre54 enrolled2 locationsNCT07724873
Recruiting
Phase 1Phase 2
REGEND001 Autologous Basal Layer Stem Cell Transplantation for Chronic Obstructive Pulmonary Disease (COPD): A Translational Application Study
Chronic Obstructive Pulmonary Disease (COPD)
Ruijin Hospital20 enrolled2 locationsNCT06946953
Recruiting
Phase 1
A Study of LY3439539 in Participants With Alzheimer's Disease
Alzheimer Disease
Eli Lilly and Company30 enrolled9 locationsNCT07598370
Recruiting
Phase 1Phase 2
A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
Sickle Cell Disease
Novartis Pharmaceuticals161 enrolled9 locationsNCT06546670
Recruiting
Phase 1Phase 2
Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous Disease
Chronic Granulomatous Disease (CGD)X-Linked Chronic Granulomatous Disease
National Institute of Allergy and Infectious Diseases (NIAID)10 enrolled1 locationNCT06325709
Recruiting
Phase 1
NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD)
InfectionChronic Granulomatous Disease
National Institute of Allergy and Infectious Diseases (NIAID)25 enrolled1 locationNCT05189925
Recruiting
Phase 1Phase 2
NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease
Menkes Disease
Stephen G. Kaler6 enrolled1 locationNCT07398508
Recruiting
Phase 1
A Clinical Trial of MK-2828 in People With Kidney Disease (MK-2828-006)
End Stage Renal DiseaseRenal ImpairmentChronic Kidney Failure
Merck Sharp & Dohme LLC24 enrolled3 locationsNCT07348237
Recruiting
Phase 1
A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD
Early-Onset Alzheimer Disease
Alnylam Pharmaceuticals60 enrolled8 locationsNCT05231785
Recruiting
Phase 1
A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease
Huntington’s Disease
Alnylam Pharmaceuticals66 enrolled19 locationsNCT06585449