Phase 1 Disease Clinical Trials
541 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 541 trials
Recruiting
Phase 1
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
HealthyMild Cognitive ImpairmentAlzheimer s Disease
National Institute of Mental Health (NIMH)90 enrolled1 locationNCT07169630
Recruiting
Phase 1Phase 2
A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
Sickle Cell Disease
Novartis Pharmaceuticals161 enrolled3 locationsNCT06546670
Recruiting
Phase 1
Relative Bioavailability Study of HNC364 Injectable Suspension
Parkinson's Disease (PD)
Guangzhou Henovcom Bioscience Co. Ltd.30 enrolled1 locationNCT06798519
Recruiting
Phase 1
Safety, Tolerability and Pharmacokinetics of AZD1613 in Adults With Autosomal Dominant Polycystic Kidney Disease
Autosomal Dominant Polycystic Kidney Disease
AstraZeneca40 enrolled15 locationsNCT07228364
Recruiting
Phase 1Phase 2
Controlling Hyperactive Immunity With Long-lived Lymphocytes
Rheumatoid Arthritis (RA)Autoimmune Rheumatologic DiseaseDiffuse Cutaneous Systemic Sclerosis+1 more
Quell Therapeutics Limited16 enrolled6 locationsNCT07473154
Recruiting
Phase 1
Haploidentical Transplantation With Pre-Transplant Immunosuppressive Therapy for Patients With Sickle Cell Disease
Sickle Cell Disease
City of Hope Medical Center11 enrolled1 locationNCT03279094
Recruiting
Phase 1
A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)
Sickle Cell Disease
Disc Medicine, Inc24 enrolled5 locationsNCT07187973
Recruiting
Phase 1Phase 2
Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection
Prostate CancerMetastatic Castration-resistant Prostate CancerUrogenital Neoplasms+3 more
Blue Earth Therapeutics Ltd82 enrolled21 locationsNCT05413850
Recruiting
Phase 1
PrP-targeting siRNA Safety & Mechanism Study
Prion Disease
Broad Institute of MIT and Harvard30 enrolled4 locationsNCT07444580
Recruiting
Phase 1
Emapalumab With Post-Transplant Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Graft-versus-Host Disease After Donor Reduced-Intensity Hematopoietic Cell Transplant
Acute Myeloid LeukemiaMyelodysplastic SyndromeGraft-Versus-Host Disease
City of Hope Medical Center15 enrolled1 locationNCT06996119
Recruiting
Phase 1
Clinical Trial of TQH3906 Capsules for the Treatment of Adult Patients With Moderately to Severely Active Ulcerative Colitis or Crohn's Disease
Inflammatory Bowel Diseases
Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.135 enrolled30 locationsNCT06754891
Recruiting
Phase 1
A Phase 1 Open-label Study to Evaluate Safety in Healthy Participants and Participants With Autoimmune Diseases
HealthyIdiopathic Inflammatory MyopathiesSystemic Sclerosis+1 more
Xencor, Inc.60 enrolled1 locationNCT07284797
Recruiting
Phase 1
Feasibility and Tolerability of IMLYGIC for the Treatment of Cutaneous Neurofibromas in Adults With NF1
NeurofibromatosisNF1Cutaneous Neurofibroma+3 more
Johns Hopkins University10 enrolled1 locationNCT07102394
Recruiting
Phase 1
Safety of a Strategy Combining Etanercept Administration With Repeated Contrast Ultrasound in Patients With Alzheimer's Disease
Alzheimer Disease
Fondation Ophtalmologique Adolphe de Rothschild5 enrolled1 locationNCT06585384
Recruiting
Phase 1Phase 2
This Clinical Trial is Designed to Evaluate the Safety, Tolerability, Feasibility and Preliminary Efficacy of NouvNeu001 (Human Dopaminergic Progenitor Cells Injection) in Patients With Parkinson's Disease.
Parkinson Disease
iRegene Therapeutics Co., Ltd.5 enrolled1 locationNCT07102342
Recruiting
Phase 1
Safety and Pharmacodynamics of QH103 Cell Injection in the Treatment of Patients With Relapsed/Refractory Antibody-Mediated Neurological Autoimmune Diseases.
Neuromyelitis Optica Spectrum Disorder (NMOSD)Multiple Sclerosis (MS)Myasthenia Gravis (MG)+4 more
Tongji Hospital6 enrolled1 locationNCT07526493
Recruiting
Phase 1
Diagnosis of Pheochromocytoma
PheochromocytomaEndocrine DiseaseEndocrine Diseases
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)3,000 enrolled1 locationNCT00004847
Recruiting
Phase 1
Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy
Multiple SclerosisProgressive Multifocal LeukoencephalopathyOther Neuroinflammatory Diseases With BBB Leakage
National Institute of Neurological Disorders and Stroke (NINDS)15 enrolled1 locationNCT05849467
Recruiting
Phase 1
A Phase I Study of [18F]Flortaucipir PET Imaging in Chinese Subjects: Safety, Pharmacokinetics, Biodistribution, Radiation Dosimetry, and Preliminary Diagnostic Efficacy
MCIAD - Alzheimer's Disease
Eli Radiopharma18 enrolled1 locationNCT07580703
Recruiting
Phase 1
Fecal Microbiota Transplantation in an Expanded Ulcerative Colitis Population
Inflammatory Bowel DiseasesUlcerative ColitisClostridioides Difficile Infection
University of Alberta85 enrolled2 locationsNCT07401680