dry eye syndrome Clinical Trials

21 recruitingLast updated: June 21, 2026

There are 21 actively recruiting dry eye syndrome clinical trials across 13 countries. Studies span Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4. Top locations include Birmingham, West Midlands, United Kingdom, Taipei, Taiwan, Taiwan, Cairo, Egypt. Updated daily from ClinicalTrials.gov.


dry eye syndrome Trials at a Glance

21 actively recruiting trials for dry eye syndrome are listed on ClinicalTrialsFinder across 6 cities in 13 countries. The largest study group is Not Applicable with 11 trials, with the heaviest enrollment activity in Birmingham, Taipei, and Cairo. Lead sponsors running dry eye syndrome studies include Taipei Veterans General Hospital, Taiwan, Aston University, and AbbVie.

Browse dry eye syndrome trials by phase

Treatments under study

About dry eye syndrome Clinical Trials

Looking for clinical trials for dry eye syndrome? There are currently 4 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new dry eye syndrome trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about dry eye syndrome clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 21 trials

Recruiting
Phase 4

The Primary Objective of the Study is to Compare Eye Dryness Following LASIK (Laser-Assisted In Situ Keratomileusis) Surgery to Eye Dryness Prior to Receiving Perioperative Miebo in Patients With Dry Eye Disease

Dry Eye Disease (DED)Dry Eye Syndrome (DES)
Vance Thompson Vision100 enrolled4 locationsNCT07650708
Recruiting
Not Applicable

The Effect of Rinsing on Ocular Inflammation and Symptoms in Patients With Dry Eye Disease

Dry EyeDry Eye SyndromesOcular Surface Disease
Rinsada33 enrolled1 locationNCT07618364
Recruiting
Not Applicable

Evaluation of a Novel Ocular Lubricating Eye Drop

Dry Eye Syndrome (DES)
Pleryon Therapeutics (Hangzhou) Limited40 enrolled1 locationNCT07593404
Recruiting
Phase 1

A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions of ABBV-319 in Adult Participants With Systemic Lupus Erythematosus (SLE) and Sjogren's Disease (SjD)

dry eye syndromeSystemic Lupus Erythematosus
AbbVie36 enrolled7 locationsNCT06977724
Recruiting
Not Applicable

Impact of Filtration on Autologous Serum Eye Drops

Dry Eye Syndrome (DES)
University Hospital, Limoges10 enrolled1 locationNCT07407101
Recruiting
Not Applicable

Therapeutic Efficacy and Safety of Non-Invasive RF Treatment in Refractory MGD

Dry Eye SyndromesMeibomian gland dysfunction
The University of Hong Kong112 enrolled2 locationsNCT06220474
Recruiting

Proteomic and Metabolomic Lacrimal Fingerprint in Diverse Pathologies of the Ocular Surface

allergic conjunctivitisdry eye syndromeMucous Membrane Pemphigoid+1 more
Centre hospitalier de l'Université de Montréal (CHUM)300 enrolled2 locationsNCT04198740
Recruiting
Not Applicable

Clinical Investigation Between the Topical Administration of a Tear Substitute With Ancillary Medicinal Substance and Hyaluronic Acid 0.3% (FBV_01) vs Hyaluronic Acid 0.3% in Subjects in the Treatment From Moderate to Severe DED

Dry Eye Disease (DED)Dry Eye Syndromes
FB Vision S.p.A74 enrolled2 locationsNCT07412860
Recruiting
Not Applicable

Photobiomodulation With REd vs BluE Light (REBEL)

Dry Eye SyndromesMeibomian gland dysfunctionBlepharitis
Aston University36 enrolled2 locationsNCT06371300
Recruiting
Not Applicable

Protecting the Eyes of Gamers With Lubricating Eyedrops

Computer vision syndromeDry Eye Syndromes
Aston University28 enrolled1 locationNCT06163989
Recruiting
Not Applicable

Autologous Serum Eye Drops in Dry Eye Syndrome

dry eye syndromeAutologous Serum Eye Drops
The General Authority for Teaching Hospitals and Institutes70 enrolled1 locationNCT07295691
Recruiting

Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)

Dry Eye SyndromesConjunctival Diseases
Fondation Ophtalmologique Adolphe de Rothschild100 enrolled1 locationNCT03358979
Recruiting
Not Applicable

Clinical Applications of Advanced Ophthalmic Imaging

DementiaMultiple SclerosisMyopia+3 more
University of Miami5,000 enrolled1 locationNCT03135327
Recruiting

Assessment of TFT by OCT in Healthy Subjects and Subjects With DES

Dry Eye Syndromes
Medical University of Vienna340 enrolled1 locationNCT02585414
Recruiting
Phase 1

Limbal Stem Cell Derived Exosome (LSC-Exo) Eye Drop for Treatment of Dry Eye

Dry Eye Syndromes
Iran University of Medical Sciences30 enrolled1 locationNCT06543667
Recruiting
Phase 2

Laser Acupuncture on Dry Eye and Sjögren's Syndrome-related Dry Eye Symptoms (LADESJS)

Dry Eye Syndrome (DES)Laser AcupunctureSjögren's Syndrome (SS)
Taipei Veterans General Hospital, Taiwan140 enrolled1 locationNCT06780293
Recruiting
Not Applicable

Efficacy of Platelet-Rich Plasma Injection in Dry Eye Syndrome

Dry Eye SyndromesSevere Dry Eye Syndromes
Centre Hospitalier Universitaire de Nice20 enrolled1 locationNCT06831253
Recruiting
Not Applicable

Difference of Tear Ferning Between Women with and Without Menopausal.

Dry Eye Syndromes
Chung Shan Medical University90 enrolled1 locationNCT06848829
Recruiting

Exosomes Proteomic for Sjogren's Syndrome and Dry Eye Syndrome

Sjogren's SyndromeDry Eye Syndrome (DES)Xerophthalmia
Taipei Veterans General Hospital, Taiwan220 enrolled1 locationNCT06771427
Recruiting

Salivary Conductivity Screening for Dry Eye Disease and Sjögren's Syndrome

Sjogren's SyndromeDry Eye Syndromes
Chang Gung Memorial Hospital200 enrolled1 locationNCT06406933