Early Stage Clinical Trials

81 recruitingLast updated: June 18, 2026

There are 81 actively recruiting early stage clinical trials across 32 countries. Studies span Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4. Top locations include Chicago, Illinois, United States, New York, New York, United States, Los Angeles, California, United States. Updated daily from ClinicalTrials.gov.


Early Stage Trials at a Glance

81 actively recruiting trials for early stage are listed on ClinicalTrialsFinder across 6 cities in 32 countries. The largest study group is Not Applicable with 30 trials, with the heaviest enrollment activity in Chicago, New York, and Los Angeles. Lead sponsors running early stage studies include Emory University, German Cancer Research Center, and Jonsson Comprehensive Cancer Center.

Browse early stage trials by phase

Treatments under study

About Early Stage Clinical Trials

Looking for clinical trials for Early Stage? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Early Stage trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Early Stage clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 81 trials

Recruiting
Not Applicable

JUdicious Surveillance for Trastuzumab Induced Cardiotoxicity in the First Year

Breast CancerBreast Cancer Early Stage Breast Cancer (Stage 1-3)Cardiovascular Health+4 more
Women's College Hospital300 enrolled1 locationNCT06930521
Recruiting

Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

Breast CancerTNBC - Triple-Negative Breast CancerEarly Stage Breast Cancer+2 more
Tempus AI900 enrolled14 locationsNCT07211178
Recruiting

Aspects of Adjuvant CDK4/6 Inhibitors in Older Breast Cancer Patients - Focusing on Geriatric Screening

Breast Cancer Early Stage Breast Cancer (Stage 1-3)Geriatric AssessmentAdjuvant Drug Therapy
Region Jönköping County200 enrolled5 locationsNCT07273357
Recruiting
Not Applicable

Outcomes and Cosmesis With Whole Breast Irradiation and Boost

Early Stage Breast Cancer
University of Wisconsin, Madison50 enrolled1 locationNCT06295744
Recruiting
Not Applicable

Single vs Hypofractionated Irradiation For Timely Access to Partial Breast Radiotherapy

Breast Cancer Early Stage Breast Cancer (Stage 1-3)
British Columbia Cancer Agency60 enrolled1 locationNCT06885671
Recruiting
Phase 3

Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage IIIA Breast Cancer AJCC v8Anatomic Stage IIIB Breast Cancer AJCC v8+1 more
Alliance for Clinical Trials in Oncology1,295 enrolled838 locationsNCT05812807
Recruiting
Phase 2

FLASH-Breast: Evaluating the Efficacy of Fezolinetant in Reducing Vasomotor Symptoms in Women With Breast Cancer on Endocrine Therapy

Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Yale University92 enrolled2 locationsNCT06917313
Recruiting
Phase 2

Fudan University Shanghai Cancer Center Breast Cancer Precision Platform Series Study- Neoadjuvant Therapy

Breast CancerBreast NeoplasmHER2-negative Breast Cancer+7 more
Fudan University716 enrolled1 locationNCT05582499
Recruiting
Not Applicable

Prospective Phase II Clinical Study of Stereotactic Body Proton Therapy (SBPT) for Lung Cancer

Lung CancerEarly Stage Lung Cancer
Guangzhou Concord Cancer Center65 enrolled1 locationNCT07412327
Recruiting
Phase 4

Evaluating the Efficacy and Safety of Lecanemab in Alzheimer's Disease Through Multi-omics Approachs

Alzheimer Dementia (AD)Alzheimer s DiseaseMCI-AD, Early Stage Alzheimer's Disease
First Affiliated Hospital of Wenzhou Medical University200 enrolled1 locationNCT07604896
Recruiting
Phase 2

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

Breast CancerBreast NeoplasmsHER2-negative Breast Cancer+8 more
QuantumLeap Healthcare Collaborative5,000 enrolled42 locationsNCT01042379
Recruiting
Not Applicable

Feasibility and Acceptibility of a Multi-site Trial of Time Restircted Eating During Chemotheraply for Breast Cancer.

Breast CancerBreast Cancer Early Stage Breast Cancer (Stage 1-3)Breast Neoplasm Female
University of Illinois at Chicago40 enrolled2 locationsNCT07387445
Recruiting
Phase 3

Early Stage Follicular LymphOma and RadioTherapy PLUS Anti-CD20 Antibody

Early Stage Follicular Lymphoma WHO Grade 1/2 or 3a
Heidelberg University100 enrolled12 locationsNCT05045664
Recruiting
Not Applicable

Septum-guided Segmentectomy for Deep Early-stage Lung Cancer (SGS2512)

Non-small Cell Lung CancerEarly Stage Lung CancerDeep-seated Lung Nodules+1 more
Shanghai Chest Hospital89 enrolled1 locationNCT07564557
Recruiting
Not Applicable

Evaluation of Circulating Tumor Cells (CTC) Relevance in Breast Cancer Follow-up Using the ScreenCell Device

Breast Cancer MetastaticBreast Cancer Early Stage Breast Cancer (Stage 1-3)Breast Cancer Invasive
ScreenCell93 enrolled1 locationNCT06807502
Recruiting
Not Applicable

Pilot Study of Aerobic Exercise During Immune Checkpoint Inhibitor Therapy in Early-Stage TNBC

Aerobic ExerciseEarly Stage Triple Negative Breast Cancer
M.D. Anderson Cancer Center33 enrolled1 locationNCT07216495
Recruiting
Phase 3

A Study to Assess the Efficacy and Safety of Zipalertinib Versus Placebo for Adjuvant Treatment in Participants With Stage IB-IIIA NSCLC With Uncommon EGFR Mutations, Following Complete Tumor Resection

Lung CancerEGFRNSCLC, Stage IB-IIIA+5 more
Taiho Oncology, Inc.360 enrolled253 locationsNCT07128199
Recruiting
Not Applicable

Inspiratory Muscle Training for Breast Cancer Patients on Chemotherapy

Early Stage Breast CarcinomaDyspnea
Ohio State University Comprehensive Cancer Center58 enrolled1 locationNCT07386444
Recruiting
Phase 2

Phase II Trial of Ivonescimab in Combination With Carboplatin + Docetaxel in Patients With Early-Stage Triple Negative Breast Cancer

TNBC - Triple-Negative Breast CancerEarly Stage Triple-Negative Breast CarcinomaTNBC
Cedars-Sinai Medical Center34 enrolled4 locationsNCT07017673
Recruiting

Patent Blue SLN in Early Ovarian Cancer Prospective Study (FIGO I-II) Evaluating Patent Blue SLN Mapping. Injection Into IP/UO Ligaments in Situ. Goals: Assess Feasibility and Accuracy vs Standard Lymphadenectomy to Minimize Surgical Morbidity

Sentinel Lymph Node Biopsy (SLNB)Early Stage Ovarian Tumors
Faculty of Medicine of Tunis30 enrolled1 locationNCT07508306