Early Stage Clinical Trials

1 recruiting

Frequently Asked Questions

Common questions about Early Stage clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 48 trials

Recruiting
Phase 2

Phase II Trial of Ivonescimab in Combination With Carboplatin + Docetaxel in Patients With Early-Stage Triple Negative Breast Cancer

TNBC - Triple-Negative Breast CancerEarly Stage Triple-Negative Breast CarcinomaTNBC
Cedars-Sinai Medical Center34 enrolled4 locationsNCT07017673
Recruiting

Patent Blue SLN in Early Ovarian Cancer Prospective Study (FIGO I-II) Evaluating Patent Blue SLN Mapping. Injection Into IP/UO Ligaments in Situ. Goals: Assess Feasibility and Accuracy vs Standard Lymphadenectomy to Minimize Surgical Morbidity

Sentinel Lymph Node Biopsy (SLNB)Early Stage Ovarian Tumors
Faculty of Medicine of Tunis30 enrolled1 locationNCT07508306
Recruiting

Evaluating the Association Among Changes in Gut Microbiome, Fatigue, and Chemotherapy-Induced Nausea in Early Stage Breast Cancer

Anatomic Stage II Breast Cancer AJCC v8Early Stage Breast CarcinomaAnatomic Stage I Breast Cancer AJCC v8+1 more
Mayo Clinic70 enrolled5 locationsNCT05417867
Recruiting
Not Applicable

Exercise Therapy to Improve Cardiovascular Health in Post-Menopausal Women After Treatment for Early Stage Breast Cancer

Early Stage Breast Cancer
Memorial Sloan Kettering Cancer Center152 enrolled2 locationsNCT04458532
Recruiting
Not Applicable

Ablation Compare With Surgery for Early Breast Cancer

Breast CancerAblationEarly Stage+1 more
Peking University People's Hospital264 enrolled1 locationNCT07484087
Recruiting

Immune Checkpoint Inhibitor Response in Solid Tumors Using a Live Tumor Diagnostic Platform

Metastatic Cervical CarcinomaMetastatic Endometrial CarcinomaMetastatic Lung Non-Small Cell Carcinoma+24 more
Mayo Clinic324 enrolled3 locationsNCT06349642
Recruiting
Not Applicable

Pilot Study of Aerobic Exercise During Immune Checkpoint Inhibitor Therapy in Early-Stage TNBC

Aerobic ExerciseEarly Stage Triple Negative Breast Cancer
M.D. Anderson Cancer Center33 enrolled1 locationNCT07216495
Recruiting
Phase 3

Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage I Breast Cancer AJCC v8+1 more
Alliance for Clinical Trials in Oncology1,295 enrolled829 locationsNCT05812807
Recruiting

Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

Breast CancerTNBC - Triple-Negative Breast CancerEarly Stage Breast Cancer+2 more
Tempus AI900 enrolled12 locationsNCT07211178
Recruiting
Phase 2

Evaluating the Use of a Medication 'Switch' vs Guideline-directed Interventions for Relieving Side Effects of Aromatase Inhibitors Among Breast Cancer Patients

Breast CancerEarly Stage Breast CancerAdjuvant Treatment
Dartmouth-Hitchcock Medical Center62 enrolled1 locationNCT07071038
Recruiting

Evaluation of HER2DX Assay on Treatment Decisions in Patients With Early Stage HER2+ Breast Cancer: the HER2BREASTDX

Breast Cancer Early Stage Breast Cancer (Stage 1-3)
European Institute of Oncology60 enrolled1 locationNCT06723990
Recruiting
Phase 2

FLASH-Breast: Evaluating the Efficacy of Fezolinetant in Reducing Vasomotor Symptoms in Women With Breast Cancer on Endocrine Therapy

Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Yale University92 enrolled2 locationsNCT06917313
Recruiting
Phase 3

ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

Anatomic Stage II Breast Cancer AJCC v8Early Stage Breast CarcinomaAnatomic Stage I Breast Cancer AJCC v8
Alliance for Clinical Trials in Oncology1,524 enrolled487 locationsNCT06876714
Recruiting
Phase 3

A Study to Assess the Efficacy and Safety of Zipalertinib Versus Placebo for Adjuvant Treatment in Participants With Stage IB-IIIA NSCLC With Uncommon EGFR Mutations, Following Complete Tumor Resection

Lung CancerEGFRNSCLC, Stage IB-IIIA+5 more
Taiho Oncology, Inc.360 enrolled214 locationsNCT07128199
Recruiting
Not Applicable

Inspiratory Muscle Training for Breast Cancer Patients on Chemotherapy

Early Stage Breast CarcinomaDyspnea
Ohio State University Comprehensive Cancer Center58 enrolled1 locationNCT07386444
Recruiting
Phase 1

Personalized Vaccine Immunotherapy in Combination With Checkpoint Inhibitor for Treatment of Triple Negative Breast Cancer

Anatomic Stage II Breast Cancer AJCC v8Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8+24 more
Emory University18 enrolled4 locationsNCT06324240
Recruiting
Phase 2Phase 3

Continuous Positive Airway Pressure (CPAP) Assisted Radiotherapy in Breast Cancer

Breast Cancer Early Stage Breast Cancer (Stage 1-3)
Universitaire Ziekenhuizen KU Leuven53 enrolled1 locationNCT07373782
Recruiting
Not Applicable

Multimodal Prehabilitation Program That Combines Physical Exercise, Psychological Intervention and Nutritional Support to Improve the Response to Neoadjuvant Chemoterhapy in Early Breast Cancer Patients

Breast Cancer Early Stage Breast Cancer (Stage 1-3)Prehabilitation
Hospital Clinic of Barcelona214 enrolled1 locationNCT07107594
Recruiting
Phase 1

Safety Trial of Antimicrobial Therapy and Precision Radiation Therapy in Patients With Oligoprogressive Non-small Cell Lung Cancer

Early Stage Non-Small Cell Lung Cancer
Abramson Cancer Center at Penn Medicine10 enrolled1 locationNCT03546829
Recruiting

Validation of the Oncoliq Test for the Early Detection of Breast Cancer.

Breast Cancer FemaleBreast Cancer DetectionBreast Cancer Early Stage Breast Cancer (Stage 1-3)+4 more
Oncoliq US Inc300 enrolled1 locationNCT07331506