Pilot Study of Aerobic Exercise During Immune Checkpoint Inhibitor Therapy in Early-Stage TNBC

This pilot study is testing whether a supervised aerobic exercise program (including treadmill walking) can be safely and effectively added to standard chemotherapy plus immunotherapy (chemoimmunotherapy) in people with early-stage triple-negative breast cancer (TNBC) who are receiving treatment before surgery. **You may be eligible if...** - You have clinical stage 2 or 3 triple-negative breast cancer (a type of breast cancer that lacks the three most common hormone receptors) - You are 18 or older - You are scheduled to receive neoadjuvant chemoimmunotherapy with carboplatin, a taxane, and pembrolizumab - You are physically able to walk independently and can march in place for 30 seconds - You are reasonably functional (ECOG 0 or 1) and can read English **You may NOT be eligible if...** - You have significant heart or respiratory disease, recent stroke or heart attack, or any condition that prevents safe exercise - You are pregnant - You are taking immune-suppressing medications (above 10 mg prednisone equivalent), beta blockers, or other immune-influencing drugs - You have an external catheter or drain that cannot accommodate exercise - You are enrolled in another therapeutic trial Talk to your doctor to see if this trial is right for you.