End of Life Clinical Trials

16 recruitingLast updated: June 18, 2026

There are 16 actively recruiting end of life clinical trials across 8 countries. Studies span Not Applicable, Phase 2. Top locations include Angers, France, Austin, Texas, United States, Barrie, Ontario, Canada. Updated daily from ClinicalTrials.gov.


End of Life Trials at a Glance

16 actively recruiting trials for end of life are listed on ClinicalTrialsFinder across 6 cities in 8 countries. The largest study group is Not Applicable with 8 trials, with the heaviest enrollment activity in Angers, Austin, and Barrie. Lead sponsors running end of life studies include Dr Benjamin Thomas, Hospices Civils de Lyon, and Centre Hospitalier Universitaire de Saint Etienne.

Browse end of life trials by phase

About End of Life Clinical Trials

Looking for clinical trials for End of Life? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new End of Life trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about End of Life clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 116 of 16 trials

Recruiting
Not Applicable

A Culturally Adapted Decision Aid Intervention to Support Chinese American Dementia Caregivers in Feeding-Related Decisions

end of life decision makingAdvanced dementiaDementia Caregivers
Yaolin Pei60 enrolled1 locationNCT07370311
Recruiting
Not Applicable

Resilience-Building for Advance Care Planning

Advanced CancerEnd of Life
University of Illinois at Chicago152 enrolled1 locationNCT07428278
Recruiting
Not Applicable

Palliative Care Education in Assisted Living for Dementia Care Providers (PCEAL-DCP)

End of LifePatient ParticipationAlzheimer Disease+3 more
University of South Florida792 enrolled2 locationsNCT06722352
Recruiting
Not Applicable

Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer

CancerEnd of Life
Stanford University2,996 enrolled17 locationsNCT05297734
Recruiting

Code Status Discussions in Muslim ICU Patients: Insights Into Physician-Family Communication

End of life careDecision Making, SharedMuslim
King Faisal Specialist Hospital & Research Center320 enrolled1 locationNCT07243041
Recruiting
Not Applicable

Eliciting Informed Goals of Care in Elderly Patients

End of LifePatient PreferenceGoals of Care
Royal Victoria Hospital, Canada1,200 enrolled1 locationNCT06002113
Recruiting

Identification of Obstacles and Levers to the Outpatient Care of Patients in Terminal Palliative Situations

End of Life
University Hospital, Strasbourg, France12 enrolled1 locationNCT07191184
Recruiting

Evaluation of the Acceptability, Appropriateness, and Feasibility/Usability of a Metastatic Breast-cancer Specific Prognostic Calculator Among Clinicians

Metastatic Breast CancerEnd of Life
UNC Lineberger Comprehensive Cancer Center15 enrolled1 locationNCT05440929
Recruiting
Not Applicable

Impact of a Protocol for Announcing Decision of Withholding and Withdrawing Life-sustaining Treatments on the Stress of the Relatives in the Emergency Departments

End of Life
Hospices Civils de Lyon538 enrolled9 locationsNCT06071078
Recruiting
Not Applicable

Embedded Palliative Care in the MICU

Quality of LifeEnd of LifeCritical Illness
Washington University School of Medicine2,600 enrolled1 locationNCT06574672
Recruiting

Practice Analysis of Care, Paraclinical Exams and Treatments Received by Geriatric Patients Both During the Last Week and the Last 24 Hours of Their Lives.

End of life care
Centre Hospitalier Universitaire de Saint Etienne100 enrolled1 locationNCT06026241
Recruiting

End-of-life Decision-making Among Young Patients With Advanced Cancer: a Grounded Theory Approach

end of life decision making
National Taiwan University Hospital30 enrolled1 locationNCT06551831
Recruiting

Burden, Mortality and Supply Costs in Intensive Care Unit Patients

End of life careMortalityFrailty+4 more
University of Ulm700 enrolled1 locationNCT04094428
Recruiting
Not Applicable

A Mouth Education Program for Dry Mouth

Dry MouthEnd of LifeFrailty+1 more
Leiden University Medical Center228 enrolled1 locationNCT05964959
Recruiting
Phase 2

DREAMS: Comparing dexmedetomidine versus midazolam at the end of life for sedative and anti-agitation effects

Distress at the end of lifeSedation at the end of life
Dr Benjamin Thomas52 enrolled3 locationsACTRN12621000052831
Recruiting

Conversations with your doctor: Making the most of medical consultations for patients with advanced incurable cancer and their carers

Communication about prognosis and end of life care planning in the advanced cancer context
The University of Sydney972 enrolled1 locationACTRN12610000724077