Epileptic Encephalopathy Clinical Trials

13 recruitingLast updated: May 13, 2026

There are 13 actively recruiting epileptic encephalopathy clinical trials across 17 countries. Studies span Not Applicable, Phase 3, Phase 1, Phase 2. Top locations include Strasbourg, France, Paris, France, Marseille, France. Updated daily from ClinicalTrials.gov.


Epileptic Encephalopathy Trials at a Glance

13 actively recruiting trials for epileptic encephalopathy are listed on ClinicalTrialsFinder across 6 cities in 17 countries. The largest study group is Not Applicable with 3 trials, with the heaviest enrollment activity in Strasbourg, Paris, and Marseille. Lead sponsors running epileptic encephalopathy studies include Praxis Precision Medicines, Boston Children's Hospital, and Azienda Ospedaliero-Universitaria di Modena.

Browse epileptic encephalopathy trials by phase

Treatments under study

About Epileptic Encephalopathy Clinical Trials

Looking for clinical trials for Epileptic Encephalopathy? There are currently 5 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Epileptic Encephalopathy trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Epileptic Encephalopathy clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 113 of 13 trials

Recruiting
Phase 1Phase 2

A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy

Epileptic Encephalopathy
Institut de Recherches Internationales Servier20 enrolled16 locationsNCT07227857
Recruiting
Phase 3

A Clinical Trial for Participants With DEE to Assess Efficacy, Safety, Tolerability, and PK of Relutrigine

Developmental and Epileptic Encephalopathy 1
Praxis Precision Medicines160 enrolled11 locationsNCT07010471
Recruiting
Phase 3

A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathies (DEE)

Developmental and Epileptic Encephalopathy
Longboard Pharmaceuticals320 enrolled109 locationsNCT06719141
Recruiting
Not Applicable

Study of Transcranial Direct Current Stimulation to Treat Epilepsy

Focal EpilepsyGeneralized Onset EpilepsySleep-related Epileptic Encephalopathy
Mayo Clinic30 enrolled1 locationNCT05673915
Recruiting

Genetics of Epilepsy and Related Disorders

EpilepsyEpileptic Encephalopathy
Boston Children's Hospital5,000 enrolled1 locationNCT01858285
Recruiting
Not Applicable

Sleep Related Memory Consolidation in Children With Age Related Focal Epilepsy.

Benign Epilepsy With Centro Temporal Spikes (BECTS)Atypical Benign Partial Epilepsy (ABPE)Epileptic Encephalopathy With Continuous Spike and Waves During Sleep (ECSWS)
University Hospital, Strasbourg, France95 enrolled2 locationsNCT03865771
Recruiting

Creation of a Register of Patients With Neonatal-onset Epileptic Encephalopathy

Epileptic Encephalopathy
Assistance Publique Hopitaux De Marseille200 enrolled15 locationsNCT04802135
Recruiting
Phase 3

A Clinical Trial of Elsunersen in Pediatric SCN2A-DEE to Assess Efficacy and Safety

Epileptic EncephalopathySCN2A Encephalopathy
Praxis Precision Medicines50 enrolled2 locationsNCT07019922
Recruiting

A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Metabolic DiseaseAMPD3, OMIM*102772, AMP Deaminase DeficiencyAK1, OMIM *103000, Adenylate Kinase Deficiency+25 more
National Human Genome Research Institute (NHGRI)999 enrolled1 locationNCT06092346
Recruiting

Developmental and Epileptic Encephalopathy of Genetic Etiology: Natural History Through Reuse of Clinical Data

Developmental and Epileptic Encephalopathy
Imagine Institute400 enrolled23 locationsNCT06380192
Recruiting

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford

Multiple Endocrine Neoplasia Type 1Multiple Endocrine Neoplasia Type 2Rare Disorders+337 more
Sanford Health20,000 enrolled2 locationsNCT01793168
Recruiting
Not Applicable

Home Ultra-long Term EEG Monitoring for Rare Epilepsies and Developmental and Epileptic Encephalopathies

EpilepsiesEpilepsies, FocalEpileptic Encephalopathy
Azienda Ospedaliero-Universitaria di Modena30 enrolled4 locationsNCT06855901
Recruiting

CNKSR2 Natural History Study

Developmental DysphasiaEpileptic Encephalopathy, Childhood-OnsetX-Linked Intellectual Disability
University of California, San Francisco15 enrolled1 locationNCT06500260