GIST Clinical Trials

9 recruiting

GIST Trials at a Glance

35 actively recruiting trials for gist are listed on ClinicalTrialsFinder across 6 cities in 20 countries. The largest study group is Phase 2 with 8 trials, with the heaviest enrollment activity in Villejuif, Philadelphia, and Marseille. Lead sponsors running gist studies include Ascentage Pharma Group Inc., Centre Leon Berard, and Chinese University of Hong Kong.

Browse gist trials by phase

Treatments under study

About GIST Clinical Trials

Looking for clinical trials for GIST? There are currently 9 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new GIST trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about GIST clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 35 trials

Recruiting
Phase 1Phase 2

A Study of Inlexisertib (DCC-3116) in Combination With Anticancer Therapies in Participants With Advanced Malignancies

GIST
Deciphera Pharmaceuticals, LLC94 enrolled25 locationsNCT05957367
Recruiting

Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis

Gastric CancerGastric NeoplasmGastrointestinal Stromal Tumor (GIST)+2 more
National Cancer Institute (NCI)400 enrolled1 locationNCT04557969
Recruiting
Phase 1

Phase I Trial to Determine the Dose and Evaluate the PK and Safety of Lutetium Lu 177 Edotreotide Therapy in Pediatric Participants With SSTR-positive Tumors

Solid TumorLymphomaGIST+5 more
ITM Solucin GmbH20 enrolled5 locationsNCT06441331
Recruiting
Phase 2

Comparing Regorafenib Combined With Envafolimab to Physician's Choice in Patients With Metastatic Gastrointestinal Stromal Tumors Harboring KIT Exon 17 Mutations Refractory to Standard Treatment

GIST - Gastrointestinal Stromal TumorKIT Gene Mutation
Jian Li100 enrolled1 locationNCT07559864
Recruiting

Familial Investigations of Childhood Cancer Predisposition

Hereditary Breast and Ovarian CancerHodgkin LymphomaAdrenocortical Carcinoma+30 more
St. Jude Children's Research Hospital1,500 enrolled1 locationNCT03050268
Recruiting
Phase 2

A Prospective, Randomized, Multicenter, Comparative Study of the Efficacy of Imatinib Resumption Combined With Atezolizumab Versus Imatinib Resumption Alone in Patients With Unresectable Advanced Gastrointestinal Stromal Tumors (GIST) After Failure of Standard Treatments

Unresectable Gastrointestinal Stromal Tumor (GIST)Locally Advanced Gastrointestinal Stromal Tumor (GIST)Metastatic Gastrointestinal Stromal Tumor
Centre Leon Berard110 enrolled13 locationsNCT05152472
Recruiting
Phase 2

KQB198 in Combination With Imatinib in Participants With Advanced/Metastatic GIST in 1st Line Setting

GISTGIST - Gastrointestinal Stromal TumorGastrointestinal Tumors+2 more
Kumquat Biosciences Inc.46 enrolled1 locationNCT07406633
Recruiting

Long-term Survivorship Challenges of Advanced/Metastatic GIST Patients Responding to Tyrosine Kinase Inhibitor Treatment: an Observational Study

Gastrointenstinal Stromal Tumor (GIST)
The Netherlands Cancer Institute330 enrolled1 locationNCT07522762
Recruiting
Phase 1

A Study of HQP1351 in Patients With GIST or Other Solid Tumors

Solid Tumor, AdultGastrointestinal Stromal Tumor (GIST)
Ascentage Pharma Group Inc.100 enrolled6 locationsNCT03594422
Recruiting
Phase 1Phase 2

Lenvatinib After Progression on Imatinib, Sunitinib, and Regorafenib for GIST Patients

GIST
Asan Medical Center48 enrolled1 locationNCT07096609
Recruiting

Speech Pattern Evaluation and Analysis for Knowledge of AD

Wisconsin Alzheimer's Disease Research CenterWisconsin Registry for Alzheimer's Prevention
University of Wisconsin, Madison165 enrolled1 locationNCT06230783
Recruiting
Not Applicable

RCT of EFTR Versus STER for GIST Treatment

GISTSmall Size Gastrointestinal Stromal Tumors
Chinese University of Hong Kong136 enrolled4 locationsNCT07411118
Recruiting
Not Applicable

Safety of Robotic Surgery for GISTs at Special Anatomic Sites

Gastrointenstinal Stromal Tumor (GIST)
The First Affiliated Hospital with Nanjing Medical University182 enrolled1 locationNCT07405125
Recruiting
Phase 1Phase 2

A Master Protocol to Evaluate DCC-3009 in Gastrointestinal Stromal Tumor (GIST)

Gastrointestinal Stromal Tumor (GIST)
Deciphera Pharmaceuticals, LLC120 enrolled10 locationsNCT06630234
Recruiting
Phase 1

A Study of Ziftomenib in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)

Gastrointestinal Stromal Tumor (GIST)Gastrointestinal Stromal NeoplasmGastrointestinal Stromal Cancer+2 more
Kura Oncology, Inc.157 enrolled32 locationsNCT06655246
Recruiting
Phase 2

Hypofractionated, 3-week, Preoperative Proton or X-ray Radiotherapy for Patients With Localized Soft Tissue Sarcoma

Soft Tissue Sarcoma AdultLeiomyosarcomaSynovial Sarcomas+6 more
Oslo University Hospital110 enrolled4 locationsNCT07169344
Recruiting

Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma

Esophageal CancerGastric (Stomach) CancerStomach Cancer+2 more
Stanford University100 enrolled1 locationNCT01048281
Recruiting

Leadless Pacemaker Registry: Outcomes and Follow-up From the University Hospital of St. Pölten

PacemakerLeadless PacemakerCardiac Pacing, Artificial+1 more
Karl Landsteiner University of Health Sciences700 enrolled1 locationNCT07246135
Recruiting
Phase 1

First-in-human Study of IDRX-42 in Participants With Metastatic and/or Unresectable Gastrointestinal Stromal Tumors

Metastatic CancerGastrointestinal NeoplasmsGastrointestinal Diseases+2 more
IDRX, Inc., a wholly owned subsidiary of GSK, LLC278 enrolled30 locationsNCT05489237
Recruiting

Valvular Heart Disease in Women Registry

Valve Disease, HeartRegistryDisparities+3 more
Valvular Heart Disease in Women Registry800 enrolled2 locationsNCT07196930