Phase 3 Glioma Clinical Trials
17 recruitingPhase 3
What is a Phase 3 trial?
Phase 3 trials compare the new treatment against the current standard of care in large groups, often hundreds to thousands of participants. Successful Phase 3 results are typically required for regulatory approval.
Showing 1–17 of 17 trials
Recruiting
Phase 3
ONC201 in H3 K27M-mutant Diffuse Glioma Following Radiotherapy (the ACTION Study)
GliomaH3 K27M
Jazz Pharmaceuticals510 enrolled162 locationsNCT05580562
Recruiting
Phase 3
A Prospective Pivotal Study to Evaluate the Efficacy and Safety of Avastin® Bevacizumab (BEV) With or Without Microbubble-mediated Focused Ultrasound (FUS-MB) Using NaviFUS System in Recurrent Glioblastoma Multiforme Patients
NeoplasmsBrain TumorGlioblastoma+5 more
NaviFUS Corporation32 enrolled2 locationsNCT06496971
Recruiting
Phase 3
SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)
GliomaAstrocytoma, IDH-Mutant, Grade 2Astrocytoma, Grade IV+5 more
Nuvation Bio Inc.365 enrolled45 locationsNCT05303519
Recruiting
Phase 3
DAY101 vs. Standard of Care Chemotherapy in Pediatric Participants With Low-Grade Glioma Requiring First-Line Systemic Therapy (LOGGIC/FIREFLY-2)
Low-grade GliomaRapidly Accelerated Fibrosarcoma (RAF) Altered GliomaPediatric Low-grade Glioma
Day One Biopharmaceuticals, Inc.400 enrolled138 locationsNCT05566795
Recruiting
Phase 3
Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases
Radiation ToxicityBrain MetastasasesHigh Grade Glioma (III or IV)+4 more
The Netherlands Cancer Institute408 enrolled5 locationsNCT06888817
Recruiting
Phase 3
Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0
Diffuse Intrinsic Pontine GliomaDiffuse Midline Glioma, H3K27-alteredDiffuse Midline Glioma, H3 K27M-Mutant
Gustave Roussy, Cancer Campus, Grand Paris433 enrolled50 locationsNCT05476939
Recruiting
Phase 3
A Clinical Study to Improve Brain Function and Quality of Life of Patients With Newly Diagnosed Brain Tumors (Gliomas).
Oligodendroglioma
University Hospital Heidelberg406 enrolled19 locationsNCT05331521
Recruiting
Phase 3
A Randomized Trial of Delayed Radiotherapy in Patients Low-grade Oligodendrogliomas Requiring a Treatment Other Than Surgery
OligodendrogliomaLow-grade Oligodendroglioma1p19q Codeletion
Hospices Civils de Lyon280 enrolled26 locationsNCT04702581
Recruiting
Phase 2Phase 3
DETERMINE Trial Treatment Arm 06: Capmatinib in Adult Patients With Cancers Harbouring MET Dysregulations
MalignancyGastric CancerSoft Tissue Sarcoma+8 more
Cancer Research UK30 enrolled17 locationsNCT06988475
Recruiting
Phase 2Phase 3
DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers.
MalignancyMelanomaCancer+8 more
Cancer Research UK30 enrolled27 locationsNCT05770544
Recruiting
Phase 3
Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM
Brain CancerGlioblastomaGBM+4 more
Northwell Health432 enrolled1 locationNCT05271240
Recruiting
Phase 3
Evaluation of Diagnostic Performances of 18F-FDOPA PET KInetics
Glioma
Central Hospital, Nancy, France88 enrolled1 locationNCT05512403
Recruiting
Phase 3
Effect of Electroacupuncture Combined With Paclitaxel Clinical Efficacy of Patients With Recurrence of High-grade Glioma
Glioma
The Third Affiliated hospital of Zhejiang Chinese Medical University58 enrolled1 locationNCT06330337
Recruiting
Phase 2Phase 3
Neuropsychological and Oncological Outcomes in Grade 2 or 3 Glioma Patients Undergoing Postoperative Modern Radiotherapy
Glioma of Brain
Chang Gung Memorial Hospital80 enrolled1 locationNCT03534050
Recruiting
Phase 3
Efficacy of Post-radiation Adjuvant Temozolomide Chemotherapy in Residue Low-grade Glioma
OligodendrogliomaAstrocytomaOligodendroastrocytoma
Sun Yat-sen University290 enrolled1 locationNCT01649830
Recruiting
Phase 2Phase 3
Radiotherapy Versus Radiotherapy Combined With Temozolomide in High-risk Low-grade Gliomas After Surgery
Low-grade Glioma
West China Hospital250 enrolled1 locationNCT04316039
Completed
Phase 3
A randomised phase III Trial on concurrent and adjuvant Temozolomide chemotherapy in non 1p/19q deleted anaplastic glioma to evaluate overall survival.
Anaplastic Glioma
University of Sydney748 enrolled5 locationsACTRN12609000485235