Early Phase 1 Glioma Clinical Trials
23 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 23 trials
Recruiting
Early Phase 1
Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG
GliomaGlioma, MalignantLow-grade Glioma+2 more
Children's Hospital of Philadelphia30 enrolled1 locationNCT05555550
Recruiting
Early Phase 1
Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG)
Brain CancerGliomaHigh Grade Glioma+1 more
Eben Rosenthal38 enrolled1 locationNCT07210632
Recruiting
Early Phase 1
Window of Opportunity Study of DSP-0390 in Gliomas
Glioma, MalignantIDH Mutation
Washington University School of Medicine20 enrolled1 locationNCT06636162
Recruiting
Early Phase 1
A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion
High Grade GliomaDiffuse Intrinsic Pontine Glioma
Nationwide Children's Hospital15 enrolled21 locationsNCT04655404
Recruiting
Early Phase 1
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion
GlioblastomaGlioblastoma MultiformeHigh Grade Glioma+6 more
Nationwide Children's Hospital15 enrolled18 locationsNCT06333899
Recruiting
Early Phase 1
In Vivo PARP-1 Expression With 18F-FluorThanatrace PET/CT in Patients With Pheochromocytoma and Paraganglioma
ParagangliomaPheochromocytoma
Heather Wachtel30 enrolled1 locationNCT05636540
Recruiting
Early Phase 1
Window-of-Opportunity Trial of Ulixertinib for MAPK-Activated Gliomas
Gliomas
M.D. Anderson Cancer Center40 enrolled1 locationNCT05804227
Recruiting
Early Phase 1
Contrast Enhanced Ultrasound in Neurosurgery to Improve Glioma Visualization and Border Demarcation
GliomaGlioma (Any Grade) in the Brain
University of Colorado, Denver100 enrolled1 locationNCT07050836
Recruiting
Early Phase 1
Sequential Treatments or Combinations Including Dasatinib, Quercetin, Fisetin and/or Temozolomide for the Treatment of Previously Treated Glioma With Residual Disease
Glioma
Mayo Clinic10 enrolled1 locationNCT07025226
Recruiting
Early Phase 1
Hyperpolarized Carbon-13 Alpha-ketoglutarate Imaging in IDH Mutant Glioma
Adult Gliomas, Mixed
Robert Bok, MD, PhD40 enrolled1 locationNCT05851378
Recruiting
Early Phase 1
Multiparametic Metabolic and Hypoxic PET/MRI for Disease Assessment in High Grade Glioma
High Grade Glioma
University of Alabama at Birmingham20 enrolled2 locationsNCT05632562
Recruiting
Early Phase 1
Study of GC101 TIL in Brain Glioma (Soochow2)
Glioma
Shanghai Juncell Therapeutics50 enrolled1 locationNCT04943913
Recruiting
Early Phase 1
18F-Fluciclovine PET-MRI in High-grade Glioma
GliomaGlioma, MalignantDiffuse Glioma+2 more
Children's Hospital of Philadelphia30 enrolled1 locationNCT05553041
Recruiting
Early Phase 1
Clinical Study for the Safety and Therapeutic Efficacy of the AI-QMMM Designed TamavaqTM Personalised Vaccine in Patients With Newly Diagnosed Glioma.
Glioma
Biogenea Pharmaceuticals Ltd.29 enrolled1 locationNCT07077616
Recruiting
Early Phase 1
A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions
GlioblastomaHigh Grade Glioma
St. Joseph's Hospital and Medical Center, Phoenix82 enrolled2 locationsNCT06072586
Recruiting
Early Phase 1
Intratumoral Extracellular Metabolic Impact of DFMO and AMXT 1501 in Patients With Diffuse or High Grade Glioma
Diffuse GliomaMalignant Glioma
Mayo Clinic18 enrolled1 locationNCT05717153
Recruiting
Early Phase 1
Implantable Microdevice In Primary Brain Tumors
GlioblastomaAstrocytomaGrade II Glioma+5 more
Oliver Jonas12 enrolled1 locationNCT04135807
Recruiting
Early Phase 1
Pilot Study of Vinblastine and Tovorafenib in Pediatric Patients With Recurrent/Progressive RAF Altered Low Grade Gliomas
Low-grade Glioma
Daniel Morgenstern57 enrolled1 locationNCT06381570
Recruiting
Early Phase 1
Study of Sonodynamic Therapy in Participants with Recurrent High-Grade Glioma
High Grade Glioma
Nader Sanai30 enrolled1 locationNCT04559685
Recruiting
Early Phase 1
Superselective Intra-arterial Cerebral Infusion of Temsirolimus in HGG
GlioblastomaGliomaGlioma, Malignant+1 more
Nader Sanai12 enrolled1 locationNCT05773326