Head and Neck Neoplasm Clinical Trials

37 recruitingLast updated: June 18, 2026

There are 37 actively recruiting head and neck neoplasm clinical trials across 21 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4. Top locations include Houston, Texas, United States, Providence, Rhode Island, United States, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Head and Neck Neoplasm Trials at a Glance

37 actively recruiting trials for head and neck neoplasm are listed on ClinicalTrialsFinder across 6 cities in 21 countries. The largest study group is Not Applicable with 11 trials, with the heaviest enrollment activity in Houston, Providence, and New York. Lead sponsors running head and neck neoplasm studies include Mayo Clinic, University of Chicago, and Associacao de Investigacao de Cuidados de Suporte em Oncologia.

Browse head and neck neoplasm trials by phase

Treatments under study

About Head and Neck Neoplasm Clinical Trials

Looking for clinical trials for Head and Neck Neoplasm? There are currently 2 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Head and Neck Neoplasm trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Head and Neck Neoplasm clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 37 trials

Recruiting

Biospecimen Procurement for Head and Neck Disorders

Head and Neck NeoplasmsLaryngeal DiseaseHearing Disorder+2 more
National Cancer Institute (NCI)1,000 enrolled9 locationsNCT03429036
Recruiting
Not Applicable

The SNAP Tool for Head and Neck Cancer Survivor-Caregiver Dyads

Head and Neck CancerSurvivorshipHead and Neck Neoplasms+1 more
Medical University of South Carolina352 enrolled1 locationNCT05811936
Recruiting
Phase 1Phase 2

Intratumoral N17350 in Advanced Solid Tumors

MelanomaCarcinoma, Non-Small Cell LungHead and Neck Neoplasms+4 more
Onchilles Pharma Inc275 enrolled1 locationNCT07339176
Recruiting
Phase 1

First in Human Study of AZD9592 in Solid Tumors

Carcinoma, Non-Small Cell LungColorectal NeoplasmsHead and Neck Neoplasms+1 more
AstraZeneca403 enrolled51 locationsNCT05647122
Recruiting
Phase 2

A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck Cancer

Head and Neck CancerHead and Neck Squamous Cell CarcinomaHead and Neck Neoplasms+2 more
University of Chicago30 enrolled1 locationNCT05420948
Recruiting
Phase 2

Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population

Head and Neck CancerOropharynx CancerClinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8+15 more
Mayo Clinic25 enrolled1 locationNCT06997068
Recruiting
Phase 3

The SWOAR Trial Sparing of Swallowing and Aspiration Related Organs at Risk & Submandibular Gland With Intensity Modulated Radiotherapy Versus Standard IMRT in Head and Neck Squamous Cell Carcinomas

Head and Neck NeoplasmsSwallowing Sparing IMRT
All India Institute of Medical Sciences136 enrolled1 locationNCT05187091
Recruiting
Not Applicable

Preventive Physical Activity Intervention in Head and Neck Cancer

Head and Neck NeoplasmsPhysical Inactivity
Sahlgrenska University Hospital80 enrolled1 locationNCT05432297
Recruiting
Not Applicable

Post-Radiation Oral Health in Underserved Head and Neck Cancer Patients

Head and Neck CarcinomaHead and Neck CancerHead and Neck Neoplasms
University of California, San Francisco120 enrolled1 locationNCT07556367
Recruiting

Oropharynx (OPX) Biomarker Trial

Head and Neck CarcinomaClinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8+8 more
Mayo Clinic560 enrolled1 locationNCT06356272
Recruiting

The EMINENCE Study - PET/MR Imaging of Head Neck Cancer

Head and Neck Neoplasms
Norwegian University of Science and Technology390 enrolled2 locationsNCT04612075
Recruiting

Molecular and Genomic Profiling of Head and Neck Tumors

Head and Neck Neoplasms
Montefiore Medical Center1,000 enrolled1 locationNCT00200486
Recruiting
Not Applicable

Ozone Therapy With Biomimetic Oral Care for Cancer-Related Oral Mucositis

Chemotherapy induced oral mucositisHead and Neck NeoplasmsOral Mucositis
University of Pavia50 enrolled1 locationNCT07491536
Recruiting

The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

Breast CancerLiver CancerEsophageal Cancer+35 more
UMC Utrecht8,000 enrolled18 locationsNCT04075305
Recruiting
Phase 2

A Study of Decreasing Radiation Therapy and Chemotherapy in People With Head and Neck Cancer

Head and Neck CarcinomaHead and Neck CancerHead and Neck Squamous Cell Carcinoma+1 more
Memorial Sloan Kettering Cancer Center12 enrolled6 locationsNCT05544136
Recruiting

Circulating Tumor DNA (ctDNA) in Locally Advanced Head and Neck Squamous Cell Carcinoma

Carcinoma, Squamous CellHead and Neck Neoplasm
UNC Lineberger Comprehensive Cancer Center50 enrolled1 locationNCT04099290
Recruiting
Phase 2

Heavy Strength Training in Head and Neck Cancer Survivors

Head and Neck CarcinomaHead and Neck CancerHead and Neck Squamous Cell Carcinoma+1 more
University of Alberta60 enrolled1 locationNCT06289049
Recruiting
Not Applicable

Association Between Health Care Provider (HCP)-Assessed ECOG Performance Status (PS) and Overall Survival, and Objectively Measure of Physical Activity (PA) Levels in Advance-cancer Patients"

Stage I Colorectal Cancer AJCC v6 and v7Stage II Colorectal Cancer AJCC v7Stage III Colorectal Cancer AJCC v7+45 more
M.D. Anderson Cancer Center590 enrolled1 locationNCT01365169
Recruiting
Not Applicable

Photobiomodulation Therapy Plus M-health in Head and Neck Cancer Patients: LAXER Study

Head and Neck CancerHead and Neck NeoplasmsXerostomia
Universidad de Granada60 enrolled1 locationNCT05106608
Recruiting
Phase 3

Head and Neck Cancer Study Project in the Geriatric Population

Head and Neck Neoplasms
Brown University20 enrolled1 locationNCT06998069