Phase 1 Healthy Volunteers Clinical Trials
157 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 157 trials
Recruiting
Phase 1Phase 2
Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms
Healthy VolunteersAlcohol Use Disorder (AUD)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)180 enrolled1 locationNCT06484075
Recruiting
Phase 1Phase 2
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Healthy VolunteersAnemia, Sickle Cell
Bristol-Myers Squibb184 enrolled34 locationsNCT06481306
Recruiting
Phase 1
A Study to See How RO7763505 Works and How Safe it is When Given to Healthy People and People With Stable Heart Disease
stable coronary artery diseaseHealthy Volunteers
Hoffmann-La Roche196 enrolled1 locationNCT07495813
Recruiting
Phase 1
A Study to Evaluate ALN-4915 in Adult Healthy Volunteers
Healthy Volunteers
Alnylam Pharmaceuticals44 enrolled1 locationNCT07535606
Recruiting
Phase 1
A Study to Assess the Drug Levels and Safety of BMS-986435 in Participants With Normal Hepatic Function and Participants With Different Degrees of Hepatic Impairment
Healthy VolunteersHepatic Impairment
Bristol-Myers Squibb24 enrolled3 locationsNCT07248839
Recruiting
Phase 1
A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and Digoxin
Healthy Volunteers
Karuna Therapeutics, Inc., a Bristol Myers Squibb company60 enrolled1 locationNCT07118215
Recruiting
Phase 1
A Brain Imaging Study to Assess the Binding of MSP-2020 to Serotonin 5-HT2A Receptors in Healthy Male Adults
Healthy Volunteers
Otsuka Pharmaceutical Development & Commercialization, Inc.18 enrolled1 locationNCT07329621
Recruiting
Phase 1
Developing Biomarkers of Dietary Intake: Dose Dependent Measurement of Sugar Intake
Healthy VolunteersDiet Therapy
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)60 enrolled1 locationNCT04799301
Recruiting
Phase 1Phase 2
A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM
Type 2 Diabetes Mellitus (T2DM)Obese or Overweight Healthy Volunteers
Alnylam Pharmaceuticals144 enrolled22 locationsNCT06845202
Recruiting
Phase 1
A Study to Evaluate ALN-4285 in Adult Healthy Volunteers
Healthy Volunteers
Alnylam Pharmaceuticals76 enrolled1 locationNCT07295717
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PRO-203 in Healthy Volunteers and Participants With Systemic Sclerosis
Healthy VolunteersSclerodermaSystemic Sclerosis (SSc)+1 more
Prolium Bioscience, Inc74 enrolled2 locationsNCT07641634
Recruiting
Phase 1
SAR447971 First-in-human Study
Healthy VolunteersHidradenitis
Sanofi114 enrolled1 locationNCT07629336
Recruiting
Phase 1
A Study of Multiple Doses of Orally Administered RO7795081 in Otherwise Healthy Chinese Adult Participants With Obesity or Overweight
Healthy VolunteersOverweight or Obesity
Hoffmann-La Roche30 enrolled2 locationsNCT07499050
Recruiting
Phase 1
A Study of Psychedelics in Healthy Older Adults With Low Well-being
Older Adults (50-90 Years)Anhedonia in Healthy Volunteers
Jennifer Mitchell80 enrolled1 locationNCT07386730
Recruiting
Phase 1
A Single Dose, Phase 1 Study of JADE101 in Healthy Japanese and Chinese Participants
Healthy Volunteers (HV)
Jade Biosciences, Inc.40 enrolled1 locationNCT07525947
Recruiting
Phase 1
A Research Study Investigating the Effect of NNC0497-0040 in Healthy Participants, Participants With Overweight or Obesity, and Participants With Type 1 Diabetes With Overweight or Obesity
ObesityHealthy VolunteersOverweight+1 more
Novo Nordisk A/S146 enrolled1 locationNCT07578584
Recruiting
Phase 1
Safety and Tolerability of ZE74-0282 in Healthy Volunteers
Healthy Volunteers
Eilean Therapeutics AU Pty Ltd40 enrolled1 locationNCT07527221
Recruiting
Phase 1
A Dose-Escalation Study of RO7875913 in Healthy Participants
Healthy Volunteers
Genentech, Inc.40 enrolled1 locationNCT07342114
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics of KL0011034 Injection in Healthy Volunteers
Healthy Volunteers
Hunan Kelun Pharmaceutical Co., Ltd.76 enrolled1 locationNCT07474545
Recruiting
Phase 1
Single-dose,First-in-human of KLA478
Healthy Volunteers
Hunan Kelun Pharmaceutical Co., Ltd.40 enrolled1 locationNCT07240675