Phase 1 Heart Clinical Trials
56 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 56 trials
Recruiting
Phase 1
Novel Approaches for Improving Vascular Function in Veterans With HFpEF
InflammationHeart Failure With Preserved Ejection Fraction
VA Office of Research and Development90 enrolled1 locationNCT06312748
Recruiting
Phase 1
A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction
Heart Failure With Reduced Ejection Fraction
Novartis Pharmaceuticals12 enrolled3 locationsNCT07465653
Recruiting
Phase 1
A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
Heart
Vasa Therapeutics42 enrolled21 locationsNCT07219511
Recruiting
Phase 1Phase 2
Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease
Heart FailureChronic Kidney DiseasesKidney Diseases+1 more
Northwestern University60 enrolled1 locationNCT05719714
Recruiting
Phase 1Phase 2
Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children
Mechanical VentilationCongenital Heart DiseaseChildren+8 more
Charite University, Berlin, Germany80 enrolled1 locationNCT07193719
Recruiting
Phase 1
A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease
Premature Coronary Heart DiseaseHeterozygous Familial Hypercholesterolemia
Verve Therapeutics, Inc.85 enrolled22 locationsNCT06164730
Recruiting
Phase 1Phase 2
A Study on Yiyang Huoluo Decoction in the Treatment of Coronary Heart Disease
Coronary Heart DiseaseCoronary Artery DiseaseAtheroscleroses
Xia Liang30 enrolled1 locationNCT07493603
Recruiting
Phase 1
Intestinal Microbiota Transplantation in Patients With Chronic Heart Failure
Chronic Heart Failure
Melana Yuzefpolskaya, MD40 enrolled1 locationNCT07490054
Recruiting
Phase 1
Autologous Induced Pluripotent Stem Cells of Cardiac Lineage for Congenital Heart Disease
Congenital Heart DiseaseHeart Failure NYHA Class IIIHeart Failure NYHA Class IV+1 more
HeartWorks, Inc.50 enrolled1 locationNCT05647213
Recruiting
Phase 1Phase 2
Treating Heart Dysfunction Related to Cancer Therapy With Sacubitril/Valsartan
Heart FailureHeart Dysfunction
Virginia Commonwealth University53 enrolled1 locationNCT05194111
Recruiting
Phase 1
Vericiguat in Decompensated Cardiac Failure: Clinical Insights on Addition to Guidelines Derived Medical Therapy-VERCIG Trial
Decompensated Heart Failure
Khawaja Danish Ali130 enrolled1 locationNCT07444398
Recruiting
Phase 1Phase 2
Safety and Efficacy of Induced Pluripotent Stem Cell-derived Engineered Human Myocardium as Biological Ventricular Assist Tissue in Terminal Heart Failure
Heart Failure
University Medical Center Goettingen53 enrolled3 locationsNCT04396899
Recruiting
Phase 1Phase 2
A Phase I/II Clinical Trial of Intramyocardial Injection of HucMSCs for the Treatment of Chronic Heart Failure
Chronic Heart FailureCoronary Artery Bypass Grafting (CABG)Chronic Ischemic Cardiomyopathy
Tasly Pharmaceutical Group Co., Ltd51 enrolled4 locationsNCT07265349
Recruiting
Phase 1
Donor Bone Marrow Derived Mesenchymal Stem Cells in Controlling Heart Failure in Patients With Cardiomyopathy Caused by Anthracyclines
Heart FailureMalignant Solid NeoplasmHematopoietic and Lymphoid Cell Neoplasm+1 more
M.D. Anderson Cancer Center72 enrolled1 locationNCT02962661
Recruiting
Phase 1
A Research Study on the Effects of NNC0537-1482 in Participants With Heart Failure
Heart Failure
Novo Nordisk A/S36 enrolled1 locationNCT07218627
Recruiting
Phase 1
The Effects of IL-1 Blockade on Inotrope Sensitivity in Patients With Heart Failure (AID-HEART)
Heart Failure
Virginia Commonwealth University20 enrolled1 locationNCT06062966
Recruiting
Phase 1Phase 2
Propranolol Treatment for Postoperative Chylothorax
Congenital Heart DiseasePostoperative Chylothorax
June Wu50 enrolled1 locationNCT06833320
Recruiting
Phase 1
: Vascular Function in Health and Disease
Heart FailureHypertensionChronic Obstructive Pulmonary Disease+1 more
Russell Richardson420 enrolled1 locationNCT02966665
Not Yet Recruiting
Phase 1
Guanethidine for Pulmonary Hypertension with Heart Failure with a Preserved Ejection Fraction (PH-HFpEF)
Heart Failure with a Preserved Ejection Fraction
Alfred Health15 enrolled1 locationACTRN12625000817448
Not Yet Recruiting
Phase 1
A study to compare safety, tolerability, and how the body processes a powdered penicillin injection (Extencilline®) given into the muscle or under the skin in healthy adults
Group A streptococcal infectionsRheumatic heart diseaseSyphilis
The Kids Research Institute Australia15 enrolled1 locationACTRN12625000684426