Phase 1 Hemoglobin Clinical Trials
14 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–14 of 14 trials
Recruiting
Phase 1
Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease
Sickle Cell DiseaseHb-SS DiseaseHemoglobin S+3 more
National Heart, Lung, and Blood Institute (NHLBI)25 enrolled1 locationNCT05904093
Recruiting
Phase 1Phase 2
Safety, Tolerability, PK and PD of ADX-038 in Healthy Participants and Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients
Paroxysmal Nocturnal Hemoglobinuria, PNH
ADARx Pharmaceuticals, Inc.50 enrolled4 locationsNCT05876312
Recruiting
Phase 1Phase 2
Phase 1/2: CD45RA Depleted Stem Cell Addback to Prevent Viral or Fungal Infections Post TCRab/CD19 Depleted HSCT
LeukemiaInborn Errors of MetabolismHLH+11 more
Children's Hospital of Philadelphia100 enrolled1 locationNCT06839456
Recruiting
Phase 1Phase 2
Study of Safety and Efficacy of HS-10542 in Patients With Paroxysmal Nocturnal Hemoglobinuria
Paroxysmal nocturnal hemoglobinuria
Jiangsu Hansoh Pharmaceutical Co., Ltd.50 enrolled1 locationNCT07470762
Recruiting
Phase 1
A Phase I Clinical Trial to Evaluate CMS-D017 Following Single and Multiple Doses in Healthy Participants
Paroxysmal Nocturnal Hemoglobinuria, PNHComplement-mediated Kidney Disease
Shenzhen Kangzhe Biotechnology Co., Ltd.88 enrolled1 locationNCT07462780
Recruiting
Phase 1Phase 2
Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases
HemoglobinopathiesMetabolic DisordersHematologic, Immune, or Bone Marrow Disorders+1 more
Washington University School of Medicine220 enrolled28 locationsNCT00920972
Recruiting
Phase 1Phase 2
A First-in-Human Safety and Efficacy Study of ALN-CFB, a Small Interfering RNA (siRNA) Targeting Complement Factor B, in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria With Persistent Anemia on a C5 Inhibitor
Paroxysmal Nocturnal Hemoglobinuria, PNHPersistent Anemia
Regeneron Pharmaceuticals24 enrolled7 locationsNCT07187401
Recruiting
Phase 1Phase 2
Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders
HemoglobinopathiesBone Marrow Failure SyndromesMetabolic Disorders+3 more
Washington University School of Medicine29 enrolled4 locationsNCT03128996
Recruiting
Phase 1
A Phase Ib, Multicenter, Open-Label Study of Multiple-Dose EA5 in Adults With Paroxysmal Nocturnal Hemoglobinuria (PNH)
PNH - Paroxysmal Nocturnal Hemoglobinuria
Shanghai Lanyi Therapeutics Co., Ltd.24 enrolled2 locationsNCT07256301
Recruiting
Phase 1
Investigation of Pharmacokinetics,Safety,and Pharmacodynamics of HSK39297 in Subjects With Hepatic Impairment
Paroxysmal Nocturnal Hemoglobinuria, PNH
Haisco Pharmaceutical Group Co., Ltd.24 enrolled1 locationNCT07152288
Recruiting
Phase 1
A Phase I Study of SNH-119014 in Healthy Volunteers
Hemoglobinopathy
ScinnoHub Pharmaceutical Co., Ltd.96 enrolled1 locationNCT07087262
Recruiting
Phase 1
131I-apamistamab-based Conditioning for Hematopoietic Stem Cell Transplant (HSCT) in Advanced Sickle Cell Disease (SCD)
Sickling Disorder Due to Hemoglobin S
Columbia University24 enrolled1 locationNCT07015684
Completed
Phase 1
Is it safe to monitor non-invasive hemoglobin in major surgery?
blood transfusionhemoglobin concentration
Ayten saracoglu20 enrolled1 locationACTRN12619001468112
Completed
Phase 1
A first in human study assessing the safety and pharmacokinetics (blood levels) of RA101495.
Paroxysmal nocturnal hemoglobinuria
Clinical Network Services Pty Ltd40 enrolled1 locationACTRN12615001143516