Hemoglobin Clinical Trials

1 recruiting

Frequently Asked Questions

Common questions about Hemoglobin clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 28 trials

Recruiting
Phase 1Phase 2

Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases

HemoglobinopathiesMetabolic DisordersHematologic, Immune, or Bone Marrow Disorders+1 more
Washington University School of Medicine220 enrolled28 locationsNCT00920972
Recruiting
Phase 3

Evaluation of Efficacy and Safety of a Single Dose of CTX001 in Participants With Transfusion-Dependent β-Thalassemia and Severe Sickle Cell Disease

Beta-ThalassemiaSickle Cell DiseaseHematologic Diseases+4 more
Vertex Pharmaceuticals Incorporated26 enrolled6 locationsNCT05477563
Recruiting
Phase 2

Cord Blood Transplant in Children and Young Adults With Blood Cancers and Non-malignant Disorders

AMLMDSHLH+6 more
Memorial Sloan Kettering Cancer Center31 enrolled1 locationNCT04644016
Recruiting
Phase 2

Allo HSCT for High Risk Hemoglobinopathies

Sickle Cell DiseaseHemoglobinopathiesGraft Failure
Masonic Cancer Center, University of Minnesota62 enrolled1 locationNCT06872333
Recruiting

The Association Between Preoperative HbA1c Levels and Postoperative Acute Kidney Injury in Isolated Coronary Artery Bypass Surgery

Acute Kidney InjuriesCoronary Bypass Graft SurgeryHemoglobin A1c Protein, Human+1 more
Osman Sila Aydin200 enrolled1 locationNCT07445997
Recruiting
Early Phase 1

Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling

Sickle Cell DiseaseThalassemiaHemoglobinopathy
National Heart, Lung, and Blood Institute (NHLBI)100 enrolled1 locationNCT06313398
Recruiting

National Longitudinal Cohort of Hematological Diseases

Acute Myeloid LeukemiaMultiple MyelomaMyelodysplastic Syndrome+14 more
Institute of Hematology & Blood Diseases Hospital, China2,300 enrolled1 locationNCT04645199
Recruiting
Phase 1

Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease

Sickle Cell DiseaseHb-SS DiseaseHemoglobin S+3 more
National Heart, Lung, and Blood Institute (NHLBI)25 enrolled1 locationNCT05904093
Recruiting

A Long-term Follow-up Study in Patients Who Received BEAM-101

Sickle Cell DiseaseHemoglobinopathy
Beam Therapeutics Inc.50 enrolled17 locationsNCT07373639
Recruiting
Phase 1Phase 2

Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders

HemoglobinopathiesBone Marrow Failure SyndromesMetabolic Disorders+3 more
Washington University School of Medicine29 enrolled4 locationsNCT03128996
Recruiting
Phase 1

A Phase Ib, Multicenter, Open-Label Study of Multiple-Dose EA5 in Adults With Paroxysmal Nocturnal Hemoglobinuria (PNH)

PNH - Paroxysmal Nocturnal Hemoglobinuria
Shanghai Lanyi Therapeutics Co., Ltd.24 enrolled2 locationsNCT07256301
Recruiting
Not Applicable

Mother Screening for Relapse Using Mid-upper Arm Circumference Among Children Recovered From Severe Acute Malnutrition (Full Scale Trial)

Malnutrition or Risk of MalnutritionAnemiaMalnutrition, Child+2 more
University of California, San Francisco2,400 enrolled1 locationNCT06599580
Recruiting

Discarded Bone Marrow for Hematology Research

Hemoglobinopathies
St. Jude Children's Research Hospital50 enrolled1 locationNCT04671212
Recruiting

Integrative Diagnosis for SCD and Other RADs

Sickle Cell DiseaseThalassaemiaStomatocytosis+6 more
Hospital Universitari Vall d'Hebron Research Institute200 enrolled9 locationsNCT07206095
Recruiting

Long Term Follow-Up Study for Individuals With Hemoglobin Disorders After Hematopoietic Cell Transplant or Gene Therapy

Hemoglobin Disorder
St. Jude Children's Research Hospital200 enrolled1 locationNCT06646640
Recruiting
Phase 1

A Phase I Study of SNH-119014 in Healthy Volunteers

Hemoglobinopathy
ScinnoHub Pharmaceutical Co., Ltd.96 enrolled1 locationNCT07087262
Recruiting
Not Applicable

Second or Greater Allogeneic Hematopoietic Stem Cell Transplant Using Reduced Intensity Conditioning (RIC)

HemoglobinopathiesImmunodeficienciesHematologic Disorders
Masonic Cancer Center, University of Minnesota30 enrolled1 locationNCT01666080
Recruiting
Phase 2

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Acute Lymphoblastic LeukemiaAcute Myeloid LeukemiaAcute Leukemia+19 more
Masonic Cancer Center, University of Minnesota70 enrolled1 locationNCT05735717
Recruiting
Not Applicable

Effectiveness of a Lifestyle Intervention for Pregnant Women With Abnormal Glucose Metabolism in Early Pregnancy: EAGM Trial

Lifestyle InterventionEarly PregnancyAdverse Pregnancy Outcomes+2 more
First Affiliated Hospital, Sun Yat-Sen University3,430 enrolled1 locationNCT06767722
Recruiting
Phase 2

TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Non-Malignant Hematological Disorders in Children

Severe Aplastic AnemiaHemoglobinopathy (Disorder)Bone Marrow Failure Syndrome
Johns Hopkins All Children's Hospital17 enrolled1 locationNCT04356469