Phase 1 HIE Clinical Trials
36 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 36 trials
Recruiting
Phase 1
Evaluating the Safety and Tolerability of Baricitinib in Patients With Job Syndrome With Lupus-Like Disease and/or Atopic Dermatitis
Atopic DermatitisLupusHyper IgE Syndrome From STAT3 Mutation+2 more
National Institute of Allergy and Infectious Diseases (NIAID)20 enrolled1 locationNCT07262983
Recruiting
Phase 1
A Study to Test the Safety and Effects of Inhaled GDC-6988 in Participants With Muco-obstructive Disease
Chronic Obstructive Pulmonary DiseaseNon-cystic Fibrosis Bronchiectasis
Genentech, Inc.128 enrolled7 locationsNCT06603246
Recruiting
Phase 1Phase 2
A Phase 1/2 Study of NKX019 in Subjects With Immune-Mediated Diseases (Ntrust-2)
Rheumatoid ArthritisIdiopathic Inflammatory MyopathiesSystemic Sclerosis+1 more
Nkarta, Inc.240 enrolled17 locationsNCT06733935
Recruiting
Phase 1
A Study of AZD0120 in Autoimmune Diseases
Rheumatoid ArthritisIdiopathic Inflammatory MyopathiesSystemic Sclerosis
AstraZeneca27 enrolled18 locationsNCT07295847
Recruiting
Phase 1Phase 2
Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders
HemoglobinopathiesBone Marrow Failure SyndromesMetabolic Disorders+3 more
Washington University School of Medicine29 enrolled4 locationsNCT03128996
Recruiting
Phase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
Rheumatoid ArthritisSystemic Lupus ErythematosusIdiopathic Inflammatory Myopathies
AstraZeneca72 enrolled37 locationsNCT06916806
Recruiting
Phase 1
A Phase 1 Open-label Study to Evaluate Safety in Healthy Participants and Participants With Autoimmune Diseases
HealthyIdiopathic Inflammatory MyopathiesSystemic Sclerosis+1 more
Xencor, Inc.60 enrolled1 locationNCT07284797
Recruiting
Phase 1
Safety and Pharmacodynamics of QH103 Cell Injection in the Treatment of Patients With Relapsed/Refractory Antibody-Mediated Neurological Autoimmune Diseases.
Neuromyelitis Optica Spectrum Disorder (NMOSD)Multiple Sclerosis (MS)Myasthenia Gravis (MG)+4 more
Tongji Hospital6 enrolled1 locationNCT07526493
Recruiting
Phase 1Phase 2
Cannabidiol for the Treatment of Diabetic Peripheral Neuropathy: Pilot Study
Diabetic NeuropathiesDiabetic Peripheral Neuropathic Pain (DPN)
Florida A&M University20 enrolled1 locationNCT07298408
Recruiting
Phase 1Phase 2
Phase 1/2: CD45RA Depleted Stem Cell Addback to Prevent Viral or Fungal Infections Post TCRab/CD19 Depleted HSCT
LeukemiaInborn Errors of MetabolismHLH+11 more
Children's Hospital of Philadelphia100 enrolled1 locationNCT06839456
Recruiting
Phase 1Phase 2
Theophylline Prophylaxis During Hypothermia to Limit Neonatal Nephron Damage
Acute Kidney InjuryHIE
Medical College of Wisconsin30 enrolled1 locationNCT05853601
Recruiting
Phase 1Phase 2
Safety of Single and Repeat Dose of PYC-001 Eye Injections in People With Autosomal Dominant Optic Atrophy (Myrtle)
Autosomal Dominant Optic AtrophyOPA1 Gene MutationHereditary Optic Atrophies+1 more
PYC Therapeutics18 enrolled3 locationsNCT06970106
Recruiting
Phase 1
Phase IA and IB Study of AAVrh.10hFXN Gene Therapy for the Cardiomyopathy of Friedreich's Ataxia
CardiomyopathiesFriedreich AtaxiaMyocardial Fibrosis+1 more
Weill Medical College of Cornell University25 enrolled1 locationNCT05302271
Recruiting
Phase 1Phase 2
Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases
HemoglobinopathiesMetabolic DisordersHematologic, Immune, or Bone Marrow Disorders+1 more
Washington University School of Medicine220 enrolled28 locationsNCT00920972
Recruiting
Phase 1Phase 2
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of Inhaled CHF6333 After Single Doses in Healthy Volunteers and After Single and Repeated Doses in Subjects With Bronchiectasis
Bronchiectasis
Chiesi Farmaceutici S.p.A.45 enrolled9 locationsNCT06166056
Recruiting
Phase 1
Validation of Oxygen Nanosensor in Mitochondrial Myopathy
Mitochondrial DiseasesMItochondrial Myopathies
Children's Hospital of Philadelphia24 enrolled1 locationNCT04086329
Recruiting
Phase 1
Validation of Nanosensor Oxygen Measurement
Mitochondrial diseaseMItochondrial Myopathies
Children's Hospital of Philadelphia96 enrolled1 locationNCT06819683
Recruiting
Phase 1
A Study of LUCAR-G79D in Subjects With Relapsed/Refractory Systemic Lupus Erythematosus (r/r SLE) and Idiopathic Inflammatory Myopathies (r/r IIM)
Systemic Lupus Erythematosus (SLE)Idiopathic Inflammatory Myopathies(IIM)
Nanjing Legend Biotech Co.38 enrolled5 locationsNCT07331272
Recruiting
Phase 1
Ketogenic Diet for Prevention of Epileptic Spasms in Infantile Onset Genetic Epilepsies
Genetic epilepsyDevelopmental and Epileptic EncephalopathiesEpileptic Spasms+1 more
Heather Olson10 enrolled1 locationNCT06700811
Recruiting
Phase 1
Phase 1b Safety Study of IMSB301 in Type 1 Interferonopathies
Type 1 Interferonopathies
ImmuneSensor Therapeutics Inc.6 enrolled1 locationNCT07364513