Phase 2 High Grade Glioma Clinical Trials
15 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–15 of 15 trials
Recruiting
Phase 1Phase 2
Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma
Brain CancerGBMGlioma+12 more
National Institute of Neurological Disorders and Stroke (NINDS)40 enrolled1 locationNCT07416188
Recruiting
Phase 2
Study of Olutasidenib and Temozolomide in HGG
Metastatic Brain TumorIDH1 MutationAstrocytoma, Grade IV+16 more
Rigel Pharmaceuticals60 enrolled20 locationsNCT06161974
Recruiting
Phase 2
Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant
Metastatic Brain TumorGlioblastomaGlioblastoma Multiforme+7 more
Nationwide Children's Hospital120 enrolled20 locationsNCT05843253
Recruiting
Phase 2
DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma
High Grade GliomaAnaplastic Astrocytoma
Ashish Shah33 enrolled1 locationNCT06264388
Recruiting
Phase 2
Intratumoral DNX-2401 for High Grade Pediatric Brain Tumors
RecurrenceRefractoryHigh Grade Glioma+4 more
Clinica Universidad de Navarra, Universidad de Navarra39 enrolled2 locationsNCT07424092
Recruiting
Phase 2
ACT001 for the Treatment of Diffuse Intrinsic Pontine Gliomas and H3K27-altered High Grade Gliomas
Diffuse Intrinsic Pontine Gliomas (DIPG)Progressive DIPGRefractory DIPG+2 more
Nationwide Children's Hospital60 enrolled20 locationsNCT06838676
Recruiting
Phase 2
Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age With NTRK1/2/3 or ROS1-FUSED CNS Tumors
CNS TumorHigh Grade Glioma
St. Jude Children's Research Hospital52 enrolled6 locationsNCT06528691
Recruiting
Phase 2
PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma
High Grade GliomaDiffuse Intrinsic Pontine GliomaRecurrent Medulloblastoma
Nationwide Children's Hospital120 enrolled13 locationsNCT05096481
Recruiting
Phase 1Phase 2
Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors
MeningiomaRecurrent Diffuse Intrinsic Pontine GliomaHigh Grade Glioma+10 more
Nationwide Children's Hospital65 enrolled4 locationsNCT05278208
Recruiting
Phase 1Phase 2
DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma
MGMT-Unmethylated GlioblastomaHigh Grade GliomaMGMT-Methylated Glioblastoma
University of California, San Francisco70 enrolled5 locationsNCT06504381
Recruiting
Phase 1Phase 2
Study of LAM561 Acid in Pediatric Patients With Malignant Glioma and Other Advanced Solid Tumors
High Grade GliomaSolid Tumor, Unspecified, Child
Laminar Pharmaceuticals28 enrolled3 locationsNCT04299191
Recruiting
Phase 1Phase 2
MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas
High Grade GliomaLow-grade Glioma
Ann & Robert H Lurie Children's Hospital of Chicago27 enrolled3 locationsNCT06712875
Recruiting
Phase 2
A Study of Chlorophyllin for the Management of Brain Radio-necrosis in Patients With Diffuse Glioma
Glioblastoma MultiformeDiffuse GliomaHigh Grade Glioma+1 more
Tata Memorial Centre118 enrolled1 locationNCT06016452
Recruiting
Phase 2
Injection of Active Allogeneic Natural Killer Cells in Patients With Gliomas
Glioma Glioblastoma MultiformeHigh Grade Glioma (III or IV)
Marzieh Ebrahimi40 enrolled1 locationNCT06687681
Terminated
Phase 2
A Phase II randomised placebo-controlled, double blind, multisite study of Acetazolamide versus placebo for management of cerebral oedema in recurrent and/or progressive High Grade Glioma requiring treatment with Dexamethasone – The ACED trial
Cerebral Oedema in recurrent, progressive and/or persistent High Grade Glioma
The University of Sydney84 enrolled11 locationsACTRN12615001072505