Phase 1 High Grade Glioma Clinical Trials
13 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–13 of 13 trials
Recruiting
Phase 1
C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)
High Grade GliomaDiffuse Intrinsic Pontine GliomaEmbryonal Tumor+1 more
Baylor College of Medicine56 enrolled1 locationNCT04099797
Recruiting
Phase 1
A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)
High Grade GliomaAdult GlioblastomaWHO Grade III or IV Malignant Glioma
University of Florida28 enrolled1 locationNCT04573140
Recruiting
Phase 1
A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma
GlioblastomaAnaplastic AstrocytomaAnaplastic Oligodendroglioma+2 more
University of Nebraska24 enrolled1 locationNCT05698524
Recruiting
Phase 1
Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252
Recurrent High Grade Glioma
Duke University51 enrolled2 locationsNCT06126744
Recruiting
Phase 1Phase 2
Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors
MeningiomaRecurrent Diffuse Intrinsic Pontine GliomaHigh Grade Glioma+10 more
Nationwide Children's Hospital65 enrolled4 locationsNCT05278208
Recruiting
Phase 1
Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)
High Grade GliomaLow-grade GliomaRecurrent World Health Organization (WHO) Grade II Glioma
University of California, San Francisco50 enrolled17 locationsNCT04485559
Recruiting
Phase 1Phase 2
DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma
MGMT-Unmethylated GlioblastomaHigh Grade GliomaMGMT-Methylated Glioblastoma
University of California, San Francisco70 enrolled5 locationsNCT06504381
Recruiting
Phase 1
Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression
GlioblastomaHigh Grade Glioma
Case Comprehensive Cancer Center10 enrolled1 locationNCT05565118
Recruiting
Phase 1
Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors
Central Nervous System NeoplasmsGlioblastomaHigh Grade Glioma+4 more
St. Jude Children's Research Hospital48 enrolled1 locationNCT05835687
Recruiting
Phase 1
STARLITE for Unresectable High-Grade Gliomas
High Grade Glioma
University of Miami24 enrolled1 locationNCT06428045
Recruiting
Phase 1
Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells
High Grade Glioma
Nationwide Children's Hospital18 enrolled1 locationNCT04254419
Recruiting
Phase 1
GD2-CAR T Cells for Pediatric Brain Tumours
Brain Tumor AdultHigh Grade GliomaDiffuse Intrinsic Pontine Glioma+4 more
Bambino Gesù Hospital and Research Institute54 enrolled1 locationNCT05298995
Recruiting
Phase 1
CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults
Diffuse Midline Glioma, H3 K27M-MutantRecurrent High Grade Glioma
OX2 Therapeutics24 enrolled1 locationNCT06305910