Phase 1 HIV Infection Clinical Trials
15 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–15 of 15 trials
Recruiting
Phase 1
MK-4646 Multiple Dose Trial in Participants With Human Immunodeficiency Virus Type 1 (HIV-1) (MK-4646-003)
HIV Infection
Merck Sharp & Dohme LLC28 enrolled2 locationsNCT07042945
Recruiting
Phase 1Phase 2
Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV Remission
HIV Infection
National Institute of Allergy and Infectious Diseases (NIAID)1,120 enrolled46 locationsNCT02140255
Recruiting
Phase 1
First Time in Human Study of Long Acting VH4524184 Formulations
HIV Infections
ViiV Healthcare268 enrolled3 locationsNCT06310551
Recruiting
Phase 1
Clinical Trial to Evaluate the Safety and Immunogenicity of Hiltonol, Poly-ICLC-adjuvanted CD40.HIVRI.Env (VRIPRO) in Adult Participants Who Previously Participated in HVTN 706
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)40 enrolled7 locationsNCT06665646
Recruiting
Phase 1
Immune Cell Therapy (CAR-T) for the Treatment of Patients With HIV and B-Cell Non-Hodgkin Lymphoma
HIV InfectionRecurrent Non-Hodgkin LymphomaRefractory Non-Hodgkin Lymphoma+11 more
AIDS Malignancy Consortium20 enrolled6 locationsNCT05077527
Recruiting
Phase 1Phase 2
CAR-T Cells for HIV Infection
HIV Infections
Steven Deeks18 enrolled2 locationsNCT04648046
Recruiting
Phase 1
Safety and Immunogenicity Study of Three mRNAs Encoding HIV Immunogens in Adult Participants Without HIV and in Overall Good Health in South Africa.
HIV Infections
International AIDS Vaccine Initiative96 enrolled6 locationsNCT06694753
Recruiting
Phase 1
A Study to Investigate the Use of VH3810109 With or Without Fostemsavir (FTR) to Reduce the Size and Activity of the Viral Reservoir in People Living With HIV
HIV Infections
ViiV Healthcare100 enrolled41 locationsNCT07053384
Recruiting
Phase 1
A Study to Investigate Pharmacokinetics, Safety and Tolerability of Long-Acting Cabotegravir Plus Recombinant Human Hyaluronidase PH20 in Healthy Adult Participants
HIV Infections
ViiV Healthcare214 enrolled3 locationsNCT05418868
Recruiting
Phase 1
Dolutegravir Pharmacokinetics Among HIV/TB Coinfected Children Receiving Standard and High-dose Rifampicin
Pediatric HIV InfectionTuberculosis Infection
Brigham and Women's Hospital20 enrolled1 locationNCT05069688
Recruiting
Phase 1
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of VH4011499 Compared to Placebo in Adults Without HIV
HIV Infections
ViiV Healthcare168 enrolled2 locationsNCT06724640
Recruiting
Phase 1
RV630 - Approach to Control HIV With Immune Enhancement and Vaccination (ACHIEV
HIV InfectionsARTAcute HIV Infection+1 more
Henry M. Jackson Foundation for the Advancement of Military Medicine48 enrolled1 locationNCT06484335
Recruiting
Phase 1Phase 2
The Tatelo Plus Study
HIV InfectionsHIV
National Institute of Allergy and Infectious Diseases (NIAID)41 enrolled2 locationsNCT06508749
Recruiting
Phase 1
Dolutegravir Pharmacokinetics During Weekly Rifapentine/Isoniazid for TB Prevention
Pediatric HIV InfectionLatent Tuberculosis
Brigham and Women's Hospital25 enrolled1 locationNCT06281834
Recruiting
Phase 1Phase 2
Pharmacokinetics, Safety, Tolerability of Dolutegravir/Rilpivirine in Pediatrics
HIV Infections
ViiV Healthcare20 enrolled8 locationsNCT05674656