Phase 1 HPV Clinical Trials
14 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–14 of 14 trials
Recruiting
Phase 1
Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer
Locally Advanced Head and Neck Squamous Cell CarcinomaClinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Stage III Hypopharyngeal Carcinoma AJCC v8+23 more
National Cancer Institute (NCI)46 enrolled18 locationsNCT05172245
Recruiting
Phase 1Phase 2
Safety and Efficacy of Allogeneic HPV-specific T Cells in Adults With Recurrent or Metastatic HPV16+ Cancers
HPV 16+ Recurrent or Metastatic Cancer
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins24 enrolled1 locationNCT04713046
Recruiting
Phase 1
TMV Vaccine Therapy Alone and With Pembrolizumab for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer
Metastatic Head and Neck Squamous Cell CarcinomaStage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8Recurrent Head and Neck Squamous Cell Carcinoma+20 more
Emory University40 enrolled2 locationsNCT06868433
Recruiting
Phase 1Phase 2
TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers
Head and Neck CancerHPV Positive Oropharyngeal Squamous Cell CarcinomaHuman Papilloma Virus+1 more
University of Chicago98 enrolled1 locationNCT05108870
Recruiting
Phase 1Phase 2
E7 T-cell Receptor (TCR) -T Cell Induction Therapy for Locoregionally Advanced HPV-associated Cancers
Cervical CancerAnal CancerPenile Cancer+14 more
Christian Hinrichs15 enrolled2 locationsNCT05639972
Recruiting
Phase 1Phase 2
A Study to Evaluate Lenti-HPV-07 Immunotherapy Against HPV+ Cervical or Oropharyngeal Cancer
HPV-Related Cervical CarcinomaHPV Positive Oropharyngeal Squamous Cell Carcinoma
Theravectys S.A.72 enrolled4 locationsNCT06319963
Recruiting
Phase 1
Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer
Resectable Head and Neck Squamous Cell CarcinomaHuman Papillomavirus-Negative Neck Squamous Cell CarcinomaResectable Human Papillomavirus-Independent Head and Neck Mucosal Squamous Cell Carcinoma+1 more
Mayo Clinic24 enrolled1 locationNCT06997094
Recruiting
Phase 1
Study of TI-0093 Injection With Recurrent/Metastatic HPV-16 Positive Solid Tumors
Cervical CancerHNSCCHPV 16+ Recurrent or Metastatic Cancer
Therorna12 enrolled1 locationNCT07081984
Recruiting
Phase 1
Personalized, Adaptive Treatment for Locally Advanced Head and Neck Cancer
HPV-Negative Squamous Cell Carcinoma
University of Chicago36 enrolled1 locationNCT06005324
Recruiting
Phase 1
Phase 1 Dose-escalation Study of FluBHPVE6E7 in HPV16-infected Women
HPV-Related Cervical CarcinomaHPV Infection
BlueSky Immunotherapies GmbH20 enrolled1 locationNCT05829629
Recruiting
Phase 1Phase 2
Safety and Efficacy of VB10.16 and Pembrolizumab in Patients with Head-Neck Squamous Cell Carcinoma
HNSCCHPV Positive Oropharyngeal Squamous Cell Carcinoma
Nykode Therapeutics ASA51 enrolled17 locationsNCT06016920
Recruiting
Phase 1
SCG142 TCR-T Cells for Human Papillomavirus-Associated Carcinomas
Cervical CancerAnal CancerPenile Cancer+5 more
The Affiliated Hospital of Qingdao University18 enrolled1 locationNCT06544720
Completed
Phase 1
A Phase Ib, single centre, open label study of a therapeutic Human Papillomavirus (HPV) DNA vaccine co-administered with an anti-PD-L1 immunotherapy, Durvalumab (MEDI4376), for recurrent and/or metastatic HPV-related Head and Neck Cancer
Head and Neck CancerHPV
University of Queensland12 enrolled1 locationACTRN12620000406909
Not Yet Recruiting
Phase 1
A study comparing Brincidofovir administered as an oral suspension versus Intravenous Formulation in Japanese and Non-Japanese Adult Volunteers
Viral Infection - orthopoxvirusesViral Infection - polyomavirusesViral Infection - human herpesviruses (HHV)+2 more
Chimerix Inc.36 enrolled1 locationACTRN12618002011268