Phase 1 Human Clinical Trials
29 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 29 trials
Recruiting
Phase 1Phase 2
Study to Assess GTAEXS617 in Participants With Advanced Solid Tumors
Head and Neck Squamous Cell Carcinoma (HNSCC)Non-small Cell Lung Cancer (NSCLC)Pancreatic Adenocarcinoma+2 more
Exscientia AI Ltd., a wholly owned subsidiary of Recursion Pharmaceuticals, Inc.230 enrolled13 locationsNCT05985655
Recruiting
Phase 1
Lenacapavir Intensification to Disrupt HIV Reservoirs in Virologically Suppressed People With HIV Receiving Antiretroviral Therapy
Human Immunodeficiency Virus
National Institute of Allergy and Infectious Diseases (NIAID)50 enrolled1 locationNCT06819176
Recruiting
Phase 1
Testing RG1-VLP Vaccine to Prevent HPV-related Cancers
Human Papillomavirus-Related Carcinoma
National Cancer Institute (NCI)18 enrolled5 locationsNCT05985681
Recruiting
Phase 1
HIV Therapeutic DNA Vaccine (ICVAX) Phase I Clinical Trial in Hong Kong
Human Immunodeficiency VirusHuman Immunodeficiency Virus I Infection
Immuno Cure Holding (HK) Limited22 enrolled1 locationNCT07530198
Recruiting
Phase 1Phase 2
Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer
Breast CancerBreast Cancer MetastaticOvarian Cancer+6 more
Incyclix Bio150 enrolled18 locationsNCT05735080
Recruiting
Phase 1
A Study on the Safety and Immune Response of Investigational mRNA Seasonal Flu/COVID-19 Combination Vaccine in Adults
Influenza, Human+COVID-19
GlaxoSmithKline225 enrolled2 locationsNCT07464314
Recruiting
Phase 1
Pharmacokinetic Study of Single-Dose Modified Release Glipizide in Healthy Volunteers
Human Gastrointestinal Physiology Data
University of Michigan40 enrolled1 locationNCT05159427
Recruiting
Phase 1Phase 2
TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers
Head and Neck CancerHPV Positive Oropharyngeal Squamous Cell CarcinomaHuman Papilloma Virus+1 more
University of Chicago98 enrolled1 locationNCT05108870
Recruiting
Phase 1
Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer
Resectable Head and Neck Squamous Cell CarcinomaHuman Papillomavirus-Negative Neck Squamous Cell CarcinomaResectable Human Papillomavirus-Independent Head and Neck Mucosal Squamous Cell Carcinoma+1 more
Mayo Clinic24 enrolled1 locationNCT06997094
Recruiting
Phase 1
The DART DELIVER-02 Study
HIV (Human Immunodeficiency Virus)
University of North Carolina, Chapel Hill24 enrolled3 locationsNCT07217379
Recruiting
Phase 1
Controlled Human Infection Study of Orally Administered Trichuris Trichiura Eggs in Naïve Adults
WhipwormTrichuriasisControlled Human Infection
George Washington University18 enrolled2 locationsNCT05706116
Recruiting
Phase 1Phase 2
Clinical Trials of Quadrivalent Influenza Vaccine
Influenza, Human
Anhui Zhifei Longcom Biologic Pharmacy Co., Ltd.620 enrolled1 locationNCT06824519
Recruiting
Phase 1
Safety and Early Efficacy of iPSC-Derived Motor Neuron Progenitor Cells (XS228) in Subacute Spinal Cord Injury: A Phase I Trial
EfficacySafetySpinal Cord Injury+4 more
XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.12 enrolled1 locationNCT06976229
Recruiting
Phase 1
Evaluation of Safety and Immunogenicity of Ad26.Mos4.HIV and CH505 TF chTrimer Combination in Healthy Adults
Human Immunodeficiency Virus
U.S. Army Medical Research and Development Command78 enrolled1 locationNCT06205056
Recruiting
Phase 1
Covid-19 and Influenza Oral Vaccine Study
Influenza, Humancovid19 Infection
Vaxine Pty Ltd100 enrolled1 locationNCT06355232
Recruiting
Phase 1
HPV DNA Vaccine Via Electroporation for HPV16 Positive Cervical Neoplasia
Human Papillomavirus Type 16Cervical Intraepithelial Neoplasia Grade IICervical Intraepithelial Neoplasia, Grade III
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins48 enrolled2 locationsNCT04131413
Recruiting
Phase 1
First-in-human Safety and Immunogenicity Study of SCB-1022 and SCB-1033 in Healthy Older Adults
Respiratory Syncytial Virus VaccinationHuman Metapneumovirus VaccinationParainfluenza Vaccination
Clover Biopharmaceuticals AUS Pty192 enrolled1 locationNCT06984094
Recruiting
Phase 1Phase 2
Effect of Honey For CIN II
Cervical Intraepithelial Neoplasia-IIHigh Risk Human Papillomavirus
Zuyderland Medisch Centrum60 enrolled2 locationsNCT06219018
Recruiting
Phase 1
Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery
Oropharyngeal CancerSquamous Cell CarcinomaHuman Papilloma Virus+1 more
Ryan Carey30 enrolled1 locationNCT06747390
Recruiting
Phase 1Phase 2
Phase Ib/IIa Clinical Study of ACC017 Tablets
Infection, Human Immunodeficiency Virus
Jiangsu Aidea Pharmaceutical Group Co., Ltd.36 enrolled1 locationNCT06719310