hyponatremia Clinical Trials

9 recruitingLast updated: May 11, 2026

There are 9 actively recruiting hyponatremia clinical trials across 6 countries. Studies span Not Applicable, Phase 3, Phase 4. Top locations include Basel, Switzerland, Cologne, Germany, Biel, Switzerland. Updated daily from ClinicalTrials.gov.


hyponatremia Trials at a Glance

9 actively recruiting trials for hyponatremia are listed on ClinicalTrialsFinder across 6 cities in 6 countries. The largest study group is Not Applicable with 4 trials, with the heaviest enrollment activity in Basel, Cologne, and Biel. Lead sponsors running hyponatremia studies include University Hospital, Basel, Switzerland, University of Cologne, and Assistance Publique - Hôpitaux de Paris.

Browse hyponatremia trials by phase

Treatments under study

About hyponatremia Clinical Trials

Looking for clinical trials for hyponatremia? There are currently 7 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new hyponatremia trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about hyponatremia clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 19 of 9 trials

Recruiting
Not Applicable

Validation of New Diagnostic Indices to Simplify Hyponatremia Therapy Assessment in Patients on Thiazide Diuretics

Thiazide Associated Hyponatremia
University Hospital, Basel, Switzerland136 enrolled1 locationNCT06381934
Recruiting
Not Applicable

Effect of Protein Supplementation and Fluid Restriction on Plasma Sodium Levels in Patients Undergoing Pituitary Surgery

hyponatremiaPituitary Surgery
University Hospital, Basel, Switzerland282 enrolled1 locationNCT07273630
Recruiting
Phase 4

Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremia

hyponatremiaKidney FailureLiver Failure+1 more
University Hospital, Basel, Switzerland172 enrolled6 locationsNCT04447911
Recruiting
Not Applicable

Regulation of Extracellular Sodium in End Stage Renal Disease Upon Volume and Electrolyte Challenges

hyponatremia
University of Cologne60 enrolled1 locationNCT06408077
Recruiting

Evaluation of Volume and Electrolyte Balance in Hyponatremia Treatment - a Prospective Observational Trial

Non-hypervolemic Hyponatremia
University of Cologne50 enrolled1 locationNCT05692726
Recruiting
Not Applicable

Protein Supplementation in Hyponatremia Due to the Syndrome of Inappropriate Antidiuresis

hyponatremiaSyndrome of Inappropriate Antidiuresis
University Hospital, Basel, Switzerland70 enrolled1 locationNCT06821802
Recruiting

Urinary Prostaglandin as a Potential Predictive Marker for Thiazide-induced Hyponatremia

Thiazide-induced Hyponatremia (TIH)
University Hospital, Basel, Switzerland232 enrolled3 locationsNCT05542056
Recruiting
Phase 3

Systematic Use of DDAVP to Prevent Serum Sodium Overcorrection in Severe Hyponatremia

hyponatremia
Assistance Publique - Hôpitaux de Paris260 enrolled12 locationsNCT06020495
Recruiting

An investigation of intraoperative maintenance fluid containing glucose 10 mg/ml to infants (1-12 moths old).

Intraoperative endogenous energy productionIntraoperative prevalence of hyponatremiaIntraoperative prevalence of hyperglycemia+3 more
Department of Paediatric Perioperative Medicine and Intensive Care, Karolinska University Hospital375 enrolled1 locationACTRN12619000833167