Early Phase 1 IC Clinical Trials
330 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 330 trials
Recruiting
Early Phase 1
CD19/BCMA-Targeted UCAR-T for Patients With Neurological Autoimmune Diseases
Relapsing or Refractory Multiple Sclerosis (MS)Myasthenia Gravis (MG)Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)+1 more
Tongji Hospital36 enrolled1 locationNCT07337785
Recruiting
Early Phase 1
L-Theanine to Support Relaxation and Mood for Cancer Patients in Surveillance
Hematopoietic and Lymphatic System NeoplasmMalignant Solid Neoplasm
City of Hope Medical Center50 enrolled4 locationsNCT07220447
Recruiting
Early Phase 1
Study of Nicotinamide Riboside Supplementation in Allogeneic Hematopoietic Cell Transplantation
Allogeneic Hematopoietic Cell Transplantation
Case Comprehensive Cancer Center20 enrolled1 locationNCT04332341
Recruiting
Early Phase 1
Pilot Study of [68Ga]Ga-ABY-025 Imaging in Patients Undergoing Treatment With HER2-targeted Therapy
Metastatic CancerHER2Locally Advanced Cancer+2 more
Vanderbilt-Ingram Cancer Center30 enrolled1 locationNCT06828588
Recruiting
Early Phase 1
Transcranial Magnetic Stimulation Treatment for Alzheimer's Disease
Alzheimer DiseaseMild Cognitive ImpairmentLogopenic Progressive Aphasia+1 more
Massachusetts General Hospital30 enrolled1 locationNCT06538311
Recruiting
Early Phase 1
Randomized Control Trial of Sleeve Gastrectomy With Tirzepatide in Maximizing Weight Loss
Obesity and Obesity-related Medical Conditions
Nicholas Skertich42 enrolled1 locationNCT06734273
Recruiting
Early Phase 1
Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients With Pancreatic Cancer
Pancreatic CancerAnxiety
Cedars-Sinai Medical Center20 enrolled1 locationNCT05086250
Recruiting
Early Phase 1
Real-Time Atherosclerosis Activity After Thoracic Radiotherapy Using Sodium Fluoride Positron Emission Tomography
Oligometastatic Disease
Katelyn Atkins10 enrolled1 locationNCT06373497
Recruiting
Early Phase 1
Smart Olfaction App to Reduce Relapse
Nicotine Dependence
University of Houston132 enrolled1 locationNCT07007195
Recruiting
Early Phase 1
Addition of Cord Blood Tissue-Derived Mesenchymal Stromal Cells to Ruxolitinib for the Treatment of Steroid-Refractory Acute Graft Versus Host Disease
Steroid refractory Graft Versus Host DiseaseHematopoietic and Lymphoid Cell Neoplasm
M.D. Anderson Cancer Center24 enrolled1 locationNCT04744116
Recruiting
Early Phase 1
Proof of Principle Study for an Efficacy Trial of Linaclotide for Cystic Fibrosis
Cystic Fibrosis (CF)
University of Nottingham26 enrolled1 locationNCT07569419
Recruiting
Early Phase 1
Repeated CBD Administration and Cannabis Outcomes
CannabisAbuse LiabilityExperimental Pain in Healthy Human Participants
Hannah Harris23 enrolled1 locationNCT07434895
Recruiting
Early Phase 1
Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease
HypopituitarismArginine vasopressin deficiencyOxytocin Deficiency+1 more
Massachusetts General Hospital20 enrolled1 locationNCT07568509
Recruiting
Early Phase 1
Allogeneic CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Vaccine After Matched Related Donor Hematopoietic Cell Transplant for the Treatment of Patients With High-Risk Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia
City of Hope Medical Center15 enrolled1 locationNCT06735690
Recruiting
Early Phase 1
First-in-human Study of the Theranostic Pair [68Ga]Ga DOTA-5G and [177Lu]Lu DOTA-ABM-5G in Pancreatic Cancer
Metastatic Pancreatic CancerLocally Advanced Pancreatic Adenocarcinoma
University of California, Davis30 enrolled1 locationNCT04665947
Recruiting
Early Phase 1
TranExamic Atomized for Pediatric Post-Operative Tonsillectomy Hemorrhage: Pilot Study
Hemorrhage, SurgicalTonsillar Bleeding
The University of Texas Health Science Center at San Antonio12 enrolled1 locationNCT06580509
Recruiting
Early Phase 1
Mental Health in Veterans and Families After Group Therapies
Post-Traumatic Stress Disorders
Soul Medicine Institute100 enrolled1 locationNCT01327690
Recruiting
Early Phase 1
Early Intervention in High Risk CCUS
Clonal Cytopenia of Undetermined SignificanceCytopenia
Lachelle D. Weeks, MD, PhD108 enrolled1 locationNCT06802146
Recruiting
Early Phase 1
Concomitant Renal and Urinary Bladder Allograft Transplantation
Chronic Kidney DiseasesBladder DysfunctionNeurogenic Bladder+6 more
Mayo Clinic30 enrolled2 locationsNCT04626167
Recruiting
Early Phase 1
A Clinical Study Evaluating the Safety and Efficacy of GT801 Injection in Adult Patients With Relapsed/Refractory CD19-positive B-cell Hematologic Malignancies and Autoimmune Hemolytic Anemia
Chronic Lymphocytic Leukemia (CLL)B-cell Acute Lymphoblastic Leukemia (B-ALL)Autoimmune Hemolytic Anemia, AIHA+1 more
Grit Biotechnology28 enrolled2 locationsNCT07205315