Early Phase 1 IC Clinical Trials
360 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 360 trials
Recruiting
Early Phase 1
A Single and Multiple Ascending Dose Trial Assessing Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ZP6590 in Participants With Normal Weight, Overweight and Obesity
First in Man Study to Evaluate Initial SafetyOverweight and Obese AdultsHealthy Participants Study
Zealand Pharma88 enrolled1 locationNCT07721597
Recruiting
Early Phase 1
Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease
HypopituitarismArginine vasopressin deficiencyOxytocin Deficiency+1 more
Massachusetts General Hospital20 enrolled1 locationNCT07568509
Recruiting
Early Phase 1
A Study to Determine the Preferred Dose of the Drug, Lisinopril, for Preventing Urinary Toxicity Following Radiotherapy for Prostate Cancer
Prostate CancerRadiation ToxicityUrinary Complication
University of Rochester30 enrolled1 locationNCT05530655
Recruiting
Early Phase 1
The Effect of Different Intra-canal Medications on Postoperative Pain
Pulp Necrosis, Apical Periodontitis
Cairo University111 enrolled1 locationNCT07603934
Recruiting
Early Phase 1
Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib
Chronic Lymphocytic Leukemia (CLL)Small Lymphocytic Lymphoma (SLL)
National Heart, Lung, and Blood Institute (NHLBI)30 enrolled1 locationNCT07428707
Recruiting
Early Phase 1
A Clinical Study Evaluating the Safety and Efficacy of GT801 Injection in Adult Patients With Relapsed/Refractory CD19-positive B-cell Hematologic Malignancies and Autoimmune Hemolytic Anemia
Chronic Lymphocytic Leukemia (CLL)B-cell Acute Lymphoblastic Leukemia (B-ALL)Autoimmune Hemolytic Anemia, AIHA+1 more
Grit Biotechnology28 enrolled2 locationsNCT07205315
Recruiting
Early Phase 1
Geisinger Antibiotic Allergy Pilot Program: Assess and Address
penicillin allergy
Geisinger Clinic100 enrolled4 locationsNCT05464615
Recruiting
Early Phase 1
Project 4: Ambulatory Biofeedback and Voice Therapy for Patients With Vocal Hyperfunction
Voice disordersMuscle Tension DysphoniaVocal Fold Polyp+1 more
Massachusetts General Hospital100 enrolled2 locationsNCT05970562
Recruiting
Early Phase 1
TEAPOT Study Multisite
Hemorrhage, SurgicalTonsillar Bleeding
The University of Texas Health Science Center at San Antonio30 enrolled3 locationsNCT07565753
Recruiting
Early Phase 1
Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast Cancer
HER2-Negative Breast CarcinomaAnatomic Stage II Breast Cancer AJCC v8Anatomic Stage III Breast Cancer AJCC v8+3 more
Emory University40 enrolled4 locationsNCT05464810
Recruiting
Early Phase 1
Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation
NeuroblastomaPineoblastomaAtypical Teratoid/Rhabdoid Tumor+11 more
C17 Council15 enrolled12 locationsNCT06942039
Recruiting
Early Phase 1
FLOAT for Healthcare PTSS
Posttraumatic stress symptomsPTSDPost-traumatic Stress Symptoms+4 more
Laureate Institute for Brain Research, Inc.15 enrolled1 locationNCT07710417
Recruiting
Early Phase 1
Safety and Preliminary Efficacy of [177Lu]Lu-RTX-2358 Combined With Immune Checkpoint Inhibitors in Patients With FAP-positive Metastatic Non-Small Cell Lung Cancer
Metastatic Non Small Cell Lung Cancer
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology36 enrolled1 locationNCT07689643
Recruiting
Early Phase 1
A Study to Evaluate the Human Biodistribution and Dosimetry of the Radionuclide Labeled IR199 in Patients With Gastric Cancer and Pancreatic Cancer
Pancreatic CancerGastric Cancer
Huashan Hospital10 enrolled1 locationNCT07707531
Recruiting
Early Phase 1
Smart Olfaction App to Reduce Relapse
Nicotine Dependence
University of Houston132 enrolled1 locationNCT07007195
Recruiting
Early Phase 1
Repeated CBD Administration and Cannabis Outcomes
CannabisAbuse LiabilityExperimental Pain in Healthy Human Participants
Hannah Harris23 enrolled1 locationNCT07434895
Recruiting
Early Phase 1
The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain.
Opioid-Refractory Chronic Cancer-Related Pain
National and Kapodistrian University of Athens24 enrolled1 locationNCT07408193
Recruiting
Early Phase 1
CAR-T Cell Therapy for ALL
Relapsed Acute Lymphoblastic Leukemia (ALL)
Dr. Zaineb Akram10 enrolled1 locationNCT07695012
Recruiting
Early Phase 1
An Investigational Scan (rhPSMA-7.3 PET/CT) for Detecting Biochemically Recurrent Prostate Cancer, ENLIGHTEN Trial
Biochemically Recurrent Prostate CarcinomaProstate Adenocarcinoma
Northwestern University27 enrolled1 locationNCT06813898
Recruiting
Early Phase 1
Evaluation of the Effectiveness and Safety of Mesotherapy in the Treatment of Chronic Low Back Pain Syndrome
Chronic Low Back Pain (Non-specific, Uncomplicated)
National Institute of Geriatrics, Rheumatology and Rehabilitation, Poland90 enrolled1 locationNCT07675304