Phase 1 Kidney Clinical Trials
83 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 83 trials
Recruiting
Phase 1
Study of 111In-XYIMSR-01 SPECT/CT in Patients With Metastatic Clear Cell Renal Cell
Renal Cell Carcinoma (Kidney Cancer)
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins6 enrolled1 locationNCT07062549
Recruiting
Phase 1
Open-Label Phase 1/2 Study of NEO-811 in Subjects With Locally Advanced or Metastatic Non-Resectable Clear Cell Renal Cell Carcinoma
Renal Cell CarcinomaClear Cell Renal Cell CarcinomaKidney Cancers+6 more
Neomorph, Inc30 enrolled11 locationsNCT07300241
Recruiting
Phase 1Phase 2
Trastuzumab Deruxtecan (DS-8201a) for the Treatment of Recurrent or Refractory Osteosarcoma, Wilms Tumor, and Desmoplastic Small Round Cell Tumor
OsteosarcomaRecurrent OsteosarcomaWilms Tumor+5 more
National Cancer Institute (NCI)55 enrolled28 locationsNCT04616560
Recruiting
Phase 1
A Clinical Trial of MK-2828 in People With Kidney Disease (MK-2828-006)
End Stage Renal DiseaseRenal ImpairmentChronic Kidney Failure
Merck Sharp & Dohme LLC24 enrolled3 locationsNCT07348237
Recruiting
Phase 1
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of OJR520 in Healthy Volunteers and Participants With Chronic Kidney Disease
Chronic Kidney Disease
Novartis Pharmaceuticals112 enrolled2 locationsNCT07235059
Recruiting
Phase 1Phase 2
Breakthrough - T1DM and Chronic Kidney Disease
Chronic Kidney DiseaseDiabete Type 1
University of Chicago10 enrolled1 locationNCT07592000
Recruiting
Phase 1
A Phase 1b Study to Evaluate the PK of CSL300 (Clazakizumab) in Chinese Subjects With End Stage Kidney Disease (ESKD)
End-Stage Kidney Disease (ESKD)
CSL Behring24 enrolled1 locationNCT07619820
Recruiting
Phase 1
Renal Impairment Study for Oral EC5026
Chronic Kidney Disease
EicOsis Human Health Inc.18 enrolled1 locationNCT07694544
Recruiting
Phase 1
BZLF1 Peptide Vaccine (OSU-2131) With QS-21 for the Prevention of Epstein-Barr Virus Related Cancer in Patients Awaiting Solid Organ Transplants
EBV-Related Lymphoproliferative DisorderPost-Transplant Lymphoproliferative DisorderChronic Kidney Disease Stage 5+2 more
Ohio State University Comprehensive Cancer Center55 enrolled1 locationNCT06741072
Recruiting
Phase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD4248 in Healthy Participants and Participants With Chronic Kidney Disease and Type 2 Diabetes and to Assess Home Measurements of Creatinine in a Non Interventional Cohort
Chronic Kidney Disease
AstraZeneca124 enrolled5 locationsNCT07024823
Recruiting
Phase 1
TLI, TBI, ATG & Hematopoietic Stem Cell Transplantation and Recipient T Regs Therapy in Living Donor Kidney Transplantation
Living Donor Kidney Transplantation
Stanford University22 enrolled2 locationsNCT03943238
Recruiting
Phase 1
Evaluation of MTX-439 in Healthy Adults and Adults With Diabetic Kidney Disease
healthy adult participantsDiabetic Kidney Disease
Mediar Therapeutics88 enrolled1 locationNCT07473323
Recruiting
Phase 1Phase 2
Intradialytic Exercise Combined With Creatine Monohydrate in Patients With Chronic Kidney Disease Undergoing Hemodialysis.
Chronic Kidney Disease 5D
Pedro Julian Flores Moreno48 enrolled1 locationNCT07666815
Recruiting
Phase 1
Adia Med of Winter Park LLC Chronic Kidney Disease Research Study
Kidney Disease, ChronicChronic Kidney DiseaseKidney Disease+2 more
Adia Med of Winter Park LLC100 enrolled1 locationNCT07572890
Recruiting
Phase 1
[212Pb]VMT-Alpha-NET in Metastatic or Inoperable Somatostatin-Receptor Positive Gastrointestinal Neuroendocrine Tumors, Pheochromocytoma/Paragangliomas, Small Cell Lung, Renal Cell, and Head and Neck Cancers
Nasopharyngeal CarcinomaKidney CancersEsthesioneuroblastoma+7 more
National Cancer Institute (NCI)120 enrolled1 locationNCT06479811
Recruiting
Phase 1Phase 2
Labile Iron Removal by Adding the Iron Chelator MEX-CD1 to Dialysate in Sepsis-Associated Acute Kidney Injury
SepsisAcute Kidney Injury
Centre Hospitalier Universitaire de Nīmes14 enrolled2 locationsNCT07236463
Recruiting
Phase 1
A Study of ONO-3310 in Healthy Adult Male Subjects and Chronic Kidney Disease Patients With Type 2 Diabetes Mellitus
Chronic Kidney DiseaseType2 Diabetes Mellitus
Ono Pharmaceutical Co., Ltd.120 enrolled1 locationNCT07619157
Recruiting
Phase 1
KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors
Non-small Cell Lung Cancer (NSCLC)Pancreatic Ductal Adenocarcinoma (PDAC)Colorectal Cancer (CRC)+4 more
Kura Oncology, Inc.300 enrolled38 locationsNCT06026410
Recruiting
Phase 1
Phase 1 Study to Evaluate the Safety and Tolerability of Intravenously Administered PYC-003
Autosomal Dominant Polycystic Kidney Disease (ADPKD
PYC Therapeutics166 enrolled10 locationsNCT06714006
Recruiting
Phase 1Phase 2
Immunological Reset to Enable Access to Hla-compatible Kidney Transplantation in Highly Sensitized Patients (RESET)
Kidney TransplantationKidney Failure, ChronicAlloimmunization+3 more
Hospital Universitari Vall d'Hebron Research Institute10 enrolled1 locationNCT07607197