Phase 1 Liver Disease Clinical Trials
21 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 21 trials
Recruiting
Phase 1
Safety, Tolerability, and Bioeffects of Alirocumab in Non-treatment Seeking Heavy Drinkers
Alcohol Associated Liver DiseaseHeavy Drinking Behavior
National Institute on Alcohol Abuse and Alcoholism (NIAAA)100 enrolled1 locationNCT04781322
Recruiting
Phase 1Phase 2
A Study to Evaluate ALN-CIDEB in Adult Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease or With Metabolic Dysfunction-Associated Steatohepatitis (MASLD/MASH)
Metabolic Dysfunction-Associated Steatotic Liver DiseaseMetabolic Dysfunction-Associated Steatohepatitis
Regeneron Pharmaceuticals132 enrolled3 locationsNCT06836609
Recruiting
Phase 1
Effect of Insulin Lowering on Lipogenesis
ObesityInsulin ResistanceNon-Alcoholic Fatty Liver Disease+2 more
Columbia University25 enrolled1 locationNCT07403604
Recruiting
Phase 1
Human Models of Selective Insulin Resistance: Alpelisib, Part I
Insulin ResistanceNon-Alcoholic Fatty Liver DiseaseOverweight and Obesity+1 more
Columbia University32 enrolled1 locationNCT06354088
Recruiting
Phase 1
Developing Microbial Therapy for MASLD: From Mechanism to Clinical Validation
Metabolic Dysfunction-Associated Steatotic Liver Disease
Leeuwenhoek Laboratories Co. Ltd.40 enrolled1 locationNCT07488975
Recruiting
Phase 1Phase 2
Immune Tolerance Induction After Liver Transplantation
Liver TransplantationEnd Stage Liver DiseaseImmune Tolerance+6 more
University of California, Los Angeles12 enrolled1 locationNCT07269041
Recruiting
Phase 1Phase 2
A Study to Evaluate the Safety and Efficacy of PN20 in the Treatment of Thrombocytopenia in Patients With Chronic Liver Disease Undergoing an Elective Procedure
Thrombocytopenia Associated With Chronic Liver Disease
Chongqing Peg-Bio Biopharm Co., Ltd.54 enrolled8 locationsNCT07446491
Recruiting
Phase 1
Hepatic Impairment With Cirrhosis Due to Cholestatic Liver Disease
CirrhosisCholestatic Liver DiseaseHepatic Impairment
Zydus Therapeutics Inc.30 enrolled1 locationNCT05045482
Recruiting
Phase 1
A Research Study of a Potential New Medicine (NNC4005-0001) for Liver Disease in Adult Participants With Increased Body Weight and Liver Fat
Fatty Liver Disease
Novo Nordisk A/S60 enrolled1 locationNCT07214870
Recruiting
Phase 1Phase 2
RTX001 Autologous Engineered Macrophages for Liver Cirrhosis
Liver DiseasesCirrhosis, LiverDecompensated Liver Cirrhosis+5 more
Resolution Therapeutics Limited30 enrolled14 locationsNCT06823713
Recruiting
Phase 1
A Study of SIPLIZUMAB in AILD and LT Patients
Autoimmune HepatitisPrimary Sclerosing CholangitisLiver Transplant Disorder+1 more
Elizabeth C. Verna8 enrolled1 locationNCT06455280
Recruiting
Phase 1
The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial
Liver DiseasesCirrhosis, LiverLiver Failure
University of Chicago24 enrolled1 locationNCT06871111
Recruiting
Phase 1
Evaluate PK & Safety of Saroglitazar in Subjects With Moderate Hepatic Impairment Due to Cholestatic Liver Disease
Cholestatic Liver Disease
Zydus Therapeutics Inc.6 enrolled1 locationNCT06825559
Recruiting
Phase 1Phase 2
CRISPR-Edited HLA Donor Liver Transplant to Reduce Rejection
Liver CancerLiver MetastasesLiver Cirrhosis+4 more
AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC90 enrolled1 locationNCT07053488
Recruiting
Phase 1Phase 2
Intestinal Microbiota Transplant in Alcohol-Associated Liver Disease
CirrhosisAlcohol Use DisorderLiver Disease; Alcohol-Related
Virginia Commonwealth University80 enrolled2 locationsNCT05548452
Recruiting
Phase 1Phase 2
Clinical Study Evaluating the Safety and Efficacy of Esomeprazole in Treatment of Non-alcoholic Steatohepatitis
Steatohepatitis, NonalcoholicFatty Liver Disease
Sadat City University46 enrolled1 locationNCT06302049
Recruiting
Phase 1
Orkambi in Patients with Cystic Fibrosis and Severe Liver Disease
Cystic FibrosisCystic Fibrosis Related Liver Disease
Dr Adeline Lim30 enrolled1 locationACTRN12619001347156
Completed
Phase 1
A drug interaction study of DUR-928 and Midozolam
Liver Disease
INC Research18 enrolled1 locationACTRN12617000579392
Recruiting
Phase 1
An Adaptive Design Study for the Assessment of the Safety, Tolerability and Pharmacokinetics of RYI-018 after Single Dosing in Healthy Volunteers and Repeat Dosing in Subjects with Non-Alcoholic Fatty Liver Disease (NAFLD)
Non-Alcoholic Fatty Liver Disease
Bird Rock Bio Inc84 enrolled3 locationsACTRN12617000133336
Completed
Phase 1
A Multiple Daily Oral Dose Study of DUR-928 in Healthy Volunteers
Treatment of Fatty Liver Disease
INC Research28 enrolled1 locationACTRN12615000267550