Phase 1 Low-grade Glioma Clinical Trials
7 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–7 of 7 trials
Recruiting
Phase 1
Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)
High Grade GliomaLow-grade GliomaRecurrent World Health Organization (WHO) Grade II Glioma
University of California, San Francisco50 enrolled17 locationsNCT04485559
Recruiting
Phase 1
A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors
MelanomaNon-small Cell Lung CancerThyroid Cancer+10 more
Pfizer124 enrolled82 locationsNCT05538130
Recruiting
Phase 1Phase 2
Phase 1/2 Study of Mirdametinib + Vinblastine for Newly Diagnosed/Previously Untreated PLGG + Activation of MAPK
Pediatric Low-grade Glioma
St. Justine's Hospital50 enrolled8 locationsNCT06666348
Recruiting
Phase 1
A Study to Assess a Medicine Called Tovorafenib in Japanese Children and Young Adults With Brain Tumours
Low-grade Glioma
Ipsen6 enrolled6 locationsNCT07441707
Recruiting
Phase 1
A Study of Avutometinib for People With Solid Tumor Cancers
Solid TumorSolid Tumor, AdultNeuroblastoma+12 more
Memorial Sloan Kettering Cancer Center23 enrolled2 locationsNCT06104488
Recruiting
Phase 1Phase 2
SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade Glioma
Low-grade GliomaRecurrent Low Grade GliomaProgressive Low-Grade Glioma
St. Jude Children's Research Hospital132 enrolled1 locationNCT04923126
Recruiting
Phase 1Phase 2
MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas
High Grade GliomaLow-grade Glioma
Ann & Robert H Lurie Children's Hospital of Chicago27 enrolled3 locationsNCT06712875