Malignant Pleural Effusion Clinical Trials

12 recruiting

Malignant Pleural Effusion Trials at a Glance

12 actively recruiting trials for malignant pleural effusion are listed on ClinicalTrialsFinder across 6 cities in 6 countries. The largest study group is Phase 1 with 7 trials, with the heaviest enrollment activity in Pittsburgh, Beijing, and Cambridge. Lead sponsors running malignant pleural effusion studies include Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute), Cambridge University Hospitals NHS Foundation Trust, and Ain Shams University.

Browse malignant pleural effusion trials by phase

Treatments under study

About Malignant Pleural Effusion Clinical Trials

Looking for clinical trials for Malignant Pleural Effusion? There are currently 12 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Malignant Pleural Effusion trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Malignant Pleural Effusion clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 112 of 12 trials

Recruiting
Phase 1

Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors

Pleural Effusion, MalignantMalignant MesotheliomaMalignant Pleural Effusion+1 more
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)10 enrolled1 locationNCT07443020
Recruiting
Phase 1

Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease

Pleural Effusion, MalignantMalignant MesotheliomaMalignant Pleural Effusion+1 more
David Bartlett, MD10 enrolled1 locationNCT07192900
Recruiting

UNC Pleural Fluid Registry

Breast CancerLung CancerLung Infection+2 more
UNC Lineberger Comprehensive Cancer Center9,999 enrolled1 locationNCT05620329
Recruiting
Not Applicable

Impact of Patient Position on Chemical Pleurodesis by Chest Ultrasound

Malignant Pleural EffusionEffect of Patient Rotation on Pleurodesis Success and Patient ComfortPleurodesis
Ain Shams University30 enrolled1 locationNCT07147270
Recruiting
Not Applicable

Impact of Pleural Manometry on the Assessment and Treatment of Malignant Pleural Effusion: A Pilot Clinical Trial

Malignant Pleural Effusions (Mpe)
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau95 enrolled1 locationNCT07120867
Recruiting
Phase 1Phase 2

A Phase Ib/II Clinical Trial of M701 in the Treatment of Malignant Pleural Effusions Caused by NSCLC

NSCLC Stage IVMalignant Pleural Effusions
Wuhan YZY Biopharma Co., Ltd.96 enrolled1 locationNCT05543330
Recruiting
Phase 1

Tocilizumab Delivered Via Pleural and Peritoneal Catheters in Patients With Advanced Metastatic Cancer

Malignant Pleural Effusion
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)12 enrolled1 locationNCT06016179
Recruiting
Not Applicable

ARMSTRONG - Air entRainMent vS sTandard tReatment in nOn-expandable luNG

Non-expandable LungTrapped LungPleural Effusion+1 more
Cambridge University Hospitals NHS Foundation Trust41 enrolled1 locationNCT06959719
Recruiting
Phase 1

A Phase Ib Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion

Malignant Pleural Effusions (Mpe)
Jemincare30 enrolled1 locationNCT06740019
Recruiting
Phase 1

A Study of MT027 in Patients with Pleural Malignant Tumors

Malignant Pleural EffusionAdvanced Malignant Solid TumorPleural Metastases+3 more
Suzhou Maximum Bio-tech Co., Ltd.18 enrolled1 locationNCT06726564
Recruiting
Not Applicable

Feasibility of Ambulatory Talc. Pleurodesis

MalignancyMalignant Pleural EffusionPalliative Care
David Rollins15 enrolled1 locationNCT06682936
Recruiting
Phase 1

OPC5: Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in Patients With Malignant Pleural Effusion.

Pleural CarcinomatosisQuality of LifeChemotherapy Effect+4 more
Odense University Hospital20 enrolled1 locationNCT06421610