Phase 2 Metastatic Melanoma Clinical Trials
26 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 26 trials
Recruiting
Phase 1Phase 2
Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer
Clinical Stage III Cutaneous Melanoma AJCC v8Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic Melanoma+10 more
National Cancer Institute (NCI)16 enrolled26 locationsNCT05896839
Recruiting
Phase 2
BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
Clinical Stage III Cutaneous Melanoma AJCC v8Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic Head and Neck Squamous Cell Carcinoma+22 more
National Cancer Institute (NCI)150 enrolled221 locationsNCT05136196
Recruiting
Phase 1Phase 2
Safety and Efficacy of OBX-115 in Advanced Solid Tumors
Lung CancerMelanomaMetastatic Lung Cancer+2 more
Obsidian Therapeutics, Inc.208 enrolled9 locationsNCT06060613
Recruiting
Phase 2
Binimetinib and Encorafenib for the Treatment of Metastatic Melanoma and Central Nervous System Metastases
Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic MelanomaPathologic Stage IV Cutaneous Melanoma AJCC v8
M.D. Anderson Cancer Center35 enrolled1 locationNCT05026983
Recruiting
Phase 2
GB1211 and Pembrolizumab Versus Pembrolizumab and Placebo in Patients With Metastatic Melanoma and Head and Neck Squamous Cell Carcinoma
Head and Neck Squamous Cell CarcinomaMetastatic Melanoma
Providence Health & Services92 enrolled1 locationNCT05913388
Recruiting
Phase 1Phase 2
Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis
Metastatic MelanomaLiver Metastases
University of Wisconsin, Madison15 enrolled1 locationNCT07281924
Recruiting
Phase 1Phase 2
Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors
Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Metastatic Triple-Negative Breast Carcinoma+97 more
Mayo Clinic132 enrolled1 locationNCT05269381
Recruiting
Phase 1Phase 2
MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma
Metastatic MelanomaMelanoma Stage IVMelanoma Stage III+1 more
Perspective Therapeutics300 enrolled13 locationsNCT05655312
Recruiting
Phase 2
Belvarafenib in Combination With Cobimetinib in Patients With Locally Advanced or Metastatic NRAS-Mutant Melanoma
Advanced or Metastatic Melanoma
Hanmi Pharmaceutical Company Limited45 enrolled10 locationsNCT07449754
Recruiting
Phase 2
Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors
Anatomic Stage IV Breast Cancer AJCC v8Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8+26 more
M.D. Anderson Cancer Center50 enrolled1 locationNCT04771520
Recruiting
Phase 2
Phase II Trial of Combination Anti-PD-1 and Aldesleukin for Metastatic Melanoma and Renal Cell Carcinoma
Metastatic MelanomaMetastatic Renal Cell CarcinomaAdvanced Locoregional Melanoma+1 more
National Cancer Institute (NCI)78 enrolled1 locationNCT05155033
Recruiting
Phase 2
A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Melanoma
Metastatic MelanomaUnresectable MelanomaMelanoma (Skin Cancer)
Iovance Biotherapeutics, Inc.100 enrolled5 locationsNCT07288203
Recruiting
Phase 1Phase 2
Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain
Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic MelanomaPathologic Stage IV Cutaneous Melanoma AJCC v8+1 more
Kari Kendra30 enrolled1 locationNCT05588453
Recruiting
Phase 1Phase 2
Phase I/II Clinical Study of JMT108 Injection for the Treatment of Advanced Malignant Melanoma
Unresectable Locally Advanced or Metastatic Melanoma
Shanghai JMT-Bio Inc.188 enrolled1 locationNCT07280832
Recruiting
Phase 2
Cryoablation+Ipilimumab+Nivolumab in Melanoma
Metastatic MelanomaSkin Cancer
Massachusetts General Hospital37 enrolled1 locationNCT05779423
Recruiting
Phase 1Phase 2
A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel
Metastatic MelanomaUnresectable MelanomaOcular Melanoma
Iovance Biotherapeutics, Inc.42 enrolled4 locationsNCT06940739
Recruiting
Phase 2
Mirdametinib in Patients With Advanced NF1-mutant Melanoma
Metastatic MelanomaAdvanced Unresectable Melanoma
Kevin Kim, MD10 enrolled1 locationNCT07237100
Recruiting
Phase 2
A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic MelanomaPathologic Stage IV Cutaneous Melanoma AJCC v8+4 more
SWOG Cancer Research Network112 enrolled331 locationsNCT04511013
Recruiting
Phase 1Phase 2
A Study of ST-1898 for Unresectable or Metastatic Melanoma
Unresectable or Metastatic Melanoma
Beijing Scitech-Mq Pharmaceuticals Limited64 enrolled1 locationNCT06359860
Recruiting
Phase 2
Ipilumumab and Nivolumab With or Without Hypofractionated Radiotherapy in Patients With Metastatic Melanoma
Metastatic Melanoma
Abramson Cancer Center at Penn Medicine54 enrolled3 locationsNCT03646617