Osteoarthritis Clinical Trials

221 recruiting

Osteoarthritis Trials at a Glance

488 actively recruiting trials for osteoarthritis are listed on ClinicalTrialsFinder across 6 cities in 51 countries. The largest study group is Not Applicable with 235 trials, with the heaviest enrollment activity in Chicago, Bologna, and New York. Lead sponsors running osteoarthritis studies include Istituto Ortopedico Rizzoli, Riphah International University, and Assistance Publique - Hôpitaux de Paris.

Browse osteoarthritis trials by phase

Treatments under study

About Osteoarthritis Clinical Trials

Looking for clinical trials for Osteoarthritis? There are currently 221 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Osteoarthritis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Osteoarthritis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 488 trials

Recruiting
Phase 3

A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients

Knee Osteoarthritis
Doron Therapeutics Inc.260 enrolled17 locationsNCT07219771
Recruiting
Phase 3

A Study to Investigate the Treatment Effect of Subcutaneous Injections of Pentosan Polysulfate Sodium Compared With Placebo in Adult Participants With Knee Osteoarthritis Pain.

Osteoarthritis, Knee
Paradigm Biopharmaceuticals Ltd.466 enrolled52 locationsNCT06917404
Recruiting

RETRO-PROSPECTIVE POSTMARKET CLINICAL STUDY FOR FX SHOULDER SOLUTIONS SHOULDER SYSTEMS

Glenohumeral OsteoarthritisAvascular Necrosis of the Head of HumerusHumeral Fracture, Proximal
FX Solutions1,004 enrolled22 locationsNCT07558590
Recruiting
Phase 4

Brain-Based and Clinical Phenotyping of Pain Pharmacotherapy in Knee Osteoarthritis

Knee Osteoarthritis
Northwestern University180 enrolled1 locationNCT06245109
Recruiting

A Prospective Total Joint Surgery Registry to Monitor Short- and Long-Term Clinical Outcomes

Osteoarthritis
Spokane Joint Replacement Center10,000 enrolled1 locationNCT06687109
Recruiting
Phase 4

Arthrosamid vs. Steroid for the Management of Knee Osteoarthritis

Osteo Arthritis KneeOsteoarthritisIntraarticular Injection
Cappagh National Orthopaedic Hospital200 enrolled1 locationNCT07489521
Recruiting
Not Applicable

Zimmer Biomet Shoulder Arthroplasty PMCF

Shoulder PainShoulder OsteoarthritisShoulder Injuries+3 more
Zimmer Biomet584 enrolled17 locationsNCT04984291
Recruiting
Phase 4

Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty

SleepKnee Osteoarthritis
University of Miami64 enrolled1 locationNCT06902285
Recruiting
Phase 4

Radiotherapy Compared to Corticosteroid Injection for Treatment of Hand Osteoarthritis

Osteoarthritis HandOsteoarthritis Wrist
Mayo Clinic165 enrolled1 locationNCT07217405
Recruiting
Not Applicable

Effect of Physical Therapy Rehabilitation on Gait and Plantar Pressure in Patients After Total Knee Replacement

Knee OsteoarthritisTotal Knee Replacement
Jouf University30 enrolled1 locationNCT07556003
Recruiting
Not Applicable

Comparative Efficacy of Intra-articular vs. MRI-guided Extra-articular Dextrose Injections in Knee Osteoarthritis Management

MRIKnee OsteoarthritisRehabilitation+3 more
Shin Kong Wu Ho-Su Memorial Hospital60 enrolled1 locationNCT06755697
Recruiting
Phase 2

A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

Osteoarthritis, Knee
Eli Lilly and Company10,000 enrolled64 locationsNCT05986292
Recruiting
Phase 3

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee

Osteoarthritis
Eli Lilly and Company800 enrolled95 locationsNCT07153471
Recruiting

Perineural Dextrose Versus Local Anesthetic Injections in Knee Osteoarthritis

Knee Osteoarthritis
Ankara Training and Research Hospital86 enrolled2 locationsNCT07381621
Recruiting
Phase 3

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

OsteoarthritisOverweight or Obesity
Eli Lilly and Company900 enrolled154 locationsNCT07353931
Recruiting
Not Applicable

Patient Outcomes Following Kinematic and Functional Alignment in Robotic-Assisted Total Knee Arthroplasty With Randomized Insert Types

Knee OsteoarthritisDegenerative Joint Disease of the Knee
Singapore General Hospital240 enrolled1 locationNCT07533188
Recruiting
Phase 2

Phase II Clinical Trial of UC-MSCs in the Treatment of Knee Osteoarthritis

Knee Osteoarthritis
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology100 enrolled3 locationsNCT07547735
Recruiting

Screening for Biomarkers of Osteoarthritis

Osteoarthritis (OA)
The First Affiliated Hospital of Xinxiang Medical College300 enrolled1 locationNCT07544823
Recruiting
Phase 1Phase 2

CBD for Pain Following Orthopedic Shoulder Surgery

Shoulder Osteoarthritis
The Methodist Hospital Research Institute80 enrolled1 locationNCT06381791
Recruiting
Not Applicable

Efficacy of Therapy With PRP Injections Versus HA in Patients With Advanced Grade of GONArthrosis

Knee Osteoarthritis
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer150 enrolled1 locationNCT07016672