Osteoarthritis Clinical Trials

604 recruitingLast updated: June 18, 2026

There are 604 actively recruiting osteoarthritis clinical trials across 57 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1, Early Phase 1. Top locations include Chicago, Illinois, United States, Bologna, Italy, New York, New York, United States. Updated daily from ClinicalTrials.gov.


Osteoarthritis Trials at a Glance

604 actively recruiting trials for osteoarthritis are listed on ClinicalTrialsFinder across 6 cities in 57 countries. The largest study group is Not Applicable with 307 trials, with the heaviest enrollment activity in Chicago, Bologna, and New York. Lead sponsors running osteoarthritis studies include Istituto Ortopedico Rizzoli, Poznan University of Medical Sciences, and Riphah International University.

Browse osteoarthritis trials by phase

Treatments under study

About Osteoarthritis Clinical Trials

Looking for clinical trials for Osteoarthritis? There are currently 233 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Osteoarthritis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Osteoarthritis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 604 trials

Recruiting
Not Applicable

Perturbation Based Balance Training Versus Progressive Neuromuscular Training as an Adjunct to Conventional Physiotherapy for Pain Reduction and Functional Improvement in Knee Osteoarthritis

Knee Arthritis, Osteoarthritis
Ibadat International University, Islamabad60 enrolled1 locationNCT07653841
Recruiting
Phase 2

Intra-Articular Allocetra in Patients With Primary Knee Osteoarthritis

Primary Knee Osteoarthritis
Enlivex Therapeutics Ltd.270 enrolled17 locationsNCT07580716
Recruiting
Not Applicable

Fluoroscopic Versus Ultrasound Guidance for Cooled Radiofrequency Ablation of Geniculate Nerves in Knee Osteoarthritis: A Randomized Control Trial

Knee Osteoarthritis
University of California, Davis90 enrolled2 locationsNCT04472702
Recruiting
Not Applicable

Percutaneous Neurostimulation in Knee Osteoarthritis

NeuromodulationOsteoarthritis(OA) of the knee
Tanta University100 enrolled1 locationNCT07637682
Recruiting

Efficacy at One Year of Combined Injections of Plasma Rich in Platelets and Hyaluronic Acid in Knee Osteoarthritis

Knee OsteoarthritisHyaluronic AcidPlatelet-Rich Plasma
Centre Hospitalier Universitaire, Amiens100 enrolled1 locationNCT05039463
Recruiting
Not Applicable

Preoperative Fasting and the Gut Microbiome Before Hip Replacement

Surgical wound infectionPostoperative ComplicationsGastrointestinal Microbiome+2 more
Charite University, Berlin, Germany130 enrolled1 locationNCT07651462
Recruiting
Not Applicable

Efficacy of Therapy With PRP Injections Versus HA in Patients With Advanced Grade of GONArthrosis

Knee Osteoarthritis
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer150 enrolled1 locationNCT07016672
Recruiting

Registry of Outcomes of Dezawa MuseCells®

longevityOsteoarthritis (OA)Pain+2 more
MuseCell Innovations Pte LTD5,000 enrolled2 locationsNCT07645989
Recruiting

Heidelberg Registry for Hip and Knee Joint Implants and Revisions

arthroplastyOsteoarthritis
University Hospital Heidelberg10,000 enrolled1 locationNCT06850818
Recruiting
Phase 2

Treatment of Patellofemoral Osteoarthritis With Engineered Cartilage.

Patellofemoral osteoarthritis
University Hospital, Basel, Switzerland75 enrolled9 locationsNCT06163573
Recruiting
Not Applicable

Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial

Osteoarthritis, Knee
Mayo Clinic128 enrolled1 locationNCT06887829
Recruiting

Post-Market Clinical Follow-Up (PMCF) Study Evaluating the Safety and Efficacy of Tıpmed™ Primary Hip Prosthesis System

Osteoarthritis (OA) of the hipTotal Hip Arthroplasty (THA)Joint Diseases+2 more
TIPMED Medical Device Manufacturing Ltd. Co.101 enrolled4 locationsNCT07651735
Recruiting
Not Applicable

Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes

knee arthropathySurgeryKnee Osteoarthritis
The Cleveland Clinic300 enrolled1 locationNCT06298721
Recruiting

Developing Allogeneic Musculoskeletal Therapies

Osteoarthritis
Keele University325 enrolled1 locationNCT06167928
Recruiting
Early Phase 1

Long-Term Effects of Mobithron Advance on Knee Osteoarthritis Aims to Investigate the Effects of Mobithron Advance on OA Progression

Osteoarthritis(OA) of the knee
Universiti Sains Malaysia84 enrolled1 locationNCT07323745
Recruiting
Not Applicable

Effect of Foot Massage on Pain and Analgesic Consumption in Total Knee Prosthesis

Knee Osteoarthritis
Alev Keskin60 enrolled1 locationNCT07126340
Recruiting

Innovations in Genicular Outcomes Registry

Knee Osteoarthritis
Pacira Pharmaceuticals, Inc10,000 enrolled19 locationsNCT05495334
Recruiting
Not Applicable

Acute Exercise Responses With Blood Flow Restriction Under Dynamic Pressure Compared to Fixed Pressure in Patients With Severe Gonarthrosis

Severe Knee Osteoarthritis
University of Valencia45 enrolled1 locationNCT07316933
Recruiting
Early Phase 1

MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)

Post-traumatic OsteoarthritisACL InjuryMeniscus Tear
Austin V Stone30 enrolled1 locationNCT04572256
Recruiting
Not Applicable

Acute Effects of Blood Flow Restriction Training to Failure on Hypoalgesia in Patients With Severe Knee Osteoarthritis Using Dynamic or Fixed Occlusion Pressure

Severe Knee Osteoarthritis
University of Valencia45 enrolled2 locationsNCT07300384