Pancreatic Insufficiency Clinical Trials

14 recruitingLast updated: May 21, 2026

There are 14 actively recruiting pancreatic insufficiency clinical trials across 7 countries. Studies span Not Applicable, Phase 4, Phase 2, Phase 1, Phase 3. Top locations include Pittsburgh, Pennsylvania, United States, Philadelphia, Pennsylvania, United States, Boston, Massachusetts, United States. Updated daily from ClinicalTrials.gov.


Pancreatic Insufficiency Trials at a Glance

14 actively recruiting trials for pancreatic insufficiency are listed on ClinicalTrialsFinder across 6 cities in 7 countries. The largest study group is Not Applicable with 3 trials, with the heaviest enrollment activity in Pittsburgh, Philadelphia, and Boston. Lead sponsors running pancreatic insufficiency studies include University of Pennsylvania, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, and Anna Evans Phillips.

Browse pancreatic insufficiency trials by phase

About Pancreatic Insufficiency Clinical Trials

Looking for clinical trials for Pancreatic Insufficiency? There are currently 3 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Pancreatic Insufficiency trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Pancreatic Insufficiency clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 114 of 14 trials

Recruiting
Phase 2

GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance

Cystic FibrosisDiabetesPancreatic Insufficiency+1 more
University of Pennsylvania30 enrolled2 locationsNCT04731272
Recruiting
Phase 3

Evaluating the Efficacy of RELiZORB in Managing Exocrine Pancreatic Insufficiency in Tube-fed Pancreatitis Patients

PancreatitisExocrine Pancreatic Insufficiency (EPI)
Massachusetts General Hospital60 enrolled1 locationNCT06691893
Recruiting
Phase 2

Phase 2 Study to Assess the Safety and Efficacy of ANG003

Cystic Fibrosis (CF)Exocrine Pancreatic Insufficiency (EPI)
Anagram Therapeutics, Inc.113 enrolled26 locationsNCT07450547
Recruiting
Phase 4

A Study Of Effect Of Secretin For In Injection (Chirostim) On Pancreatic Fluid Composition In Healthy Subjects

Chronic PancreatitisExocrine Pancreatic Insufficiency
Mayo Clinic24 enrolled1 locationNCT07285863
Recruiting
Phase 4

Malabsorption Blood Test (MBT) to Determine Exocrine Pancreatic Function and Related Quality of Life in Chronic Pancreatitis

Chronic PancreatitisExocrine Pancreatic InsufficiencyRecurrent Acute Pancreatitis
Anna Evans Phillips80 enrolled2 locationsNCT07418593
Recruiting
Phase 1

Dorzagliatin in Pancreatic Insufficient Cystic Fibrosis

Cystic Fibrosis-related DiabetesPancreatic Insufficiency
University of Pennsylvania15 enrolled2 locationsNCT06995651
Recruiting

Assessment of Pancreatic Dysfunction in Patients With Type 2 Diabetes

Type 2 Diabetes Mellitus (T2DM)Pancreatogenic Diabetes MellitusExocrine Pancreatic Insufficiency (EPI)
West Kazakhstan Marat Ospanov Medical University310 enrolled1 locationNCT07512934
Recruiting
Not Applicable

Evaluating the Utility of RELiZORB™ for Treating Feeding Intolerance in Critically Ill Adults With Multi-Organ Failure

Exocrine Pancreatic InsufficiencyMulti Organ Failure
Inova Health Care Services32 enrolled1 locationNCT05710315
Recruiting
Not Applicable

Beta-cell Response to Incretin Hormones in Cystic Fibrosis

Cystic FibrosisPancreatic Insufficiency
University of Pennsylvania45 enrolled1 locationNCT01851694
Recruiting
Phase 4

Pancreatic Enzyme Replacement Therapy for Acute Pancreatitis-Associated Exocrine Pancreatic Insufficiency

Exocrine Pancreatic Insufficiency
Ohio State University60 enrolled5 locationsNCT06477159
Recruiting

Shwachman-Diamond Syndrome Global Patient Survey and Partnering Platform

Myelodysplastic SyndromesShwachman-Diamond SyndromeSDS+24 more
Shwachman-Diamond Syndrome Alliance Inc8,000 enrolled1 locationNCT06999954
Recruiting

Investigating Predictive Factors of Diabetes Occurence After Duodenalpancreatectomy

Glucose metabolismDiabetesExocrine Pancreatic Insufficiency+4 more
Fondazione Policlinico Universitario Agostino Gemelli IRCCS100 enrolled1 locationNCT02175459
Recruiting
Not Applicable

The Effects of Pancreatic Enzyme Supplementation in Critically Ill Patients on Enteral Feeding

enteral feedingExocrine Pancreatic InsufficiencyCritically Ill
Seoul National University Hospital170 enrolled1 locationNCT05112328
Recruiting

MS1819-SD phase IIa clinical trial for patients with exocrine pancreatic insufficiency (EPI) caused by chronic pancreatitis (CP) and/or distal pancreatectomy.

Exocrine pancreatic insufficiency (EPI) caused by chronic pancreatitis (CP)Exocrine pancreatic insufficiency (EPI) caused by distal pancreatectomy.
INC Research Australia Pty Ltd13 enrolled6 locationsACTRN12616000962437