Phase 1 PAP Clinical Trials
18 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–18 of 18 trials
Recruiting
Phase 1
Testing RG1-VLP Vaccine to Prevent HPV-related Cancers
Human Papillomavirus-Related Carcinoma
National Cancer Institute (NCI)18 enrolled5 locationsNCT05985681
Recruiting
Phase 1Phase 2
Palbociclib and Sasanlimab for the Treatment of Advanced Clear Cell Renal Cell Carcinoma (ccRCC) or Papillary Renal Cell Carcinoma (pRCC)
Advanced Clear Cell Renal Carcinoma (Ccrcc)Papillary Renal Cell Carcinoma (Prcc)
National Cancer Institute (NCI)100 enrolled1 locationNCT05665361
Recruiting
Phase 1
Autologous Dendritic Cell Vaccine For Recurrent Respiratory Papillomatosis (RRP) Patients
Recurrent Respiratory Papillomatosis
Mayo Clinic9 enrolled1 locationNCT07317154
Recruiting
Phase 1
Study to Determine the Safety and Pharmacokinetics of DO-2 in Patients With Advanced or Refractory Solid Tumours
Lung CancerAdvanced Solid TumorNon-small Cell Lung Cancer+4 more
DeuterOncology55 enrolled13 locationsNCT05752552
Recruiting
Phase 1Phase 2
TheraT® Vectors (Vaccines) Combined With Chemotherapy to Treat HPV16 Head and Neck Cancers
Head and Neck CancerHPV Positive Oropharyngeal Squamous Cell CarcinomaHuman Papilloma Virus+1 more
University of Chicago98 enrolled1 locationNCT05108870
Recruiting
Phase 1Phase 2
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
Ovarian CarcinomaColorectal CarcinomaMelanoma+19 more
Children's Oncology Group147 enrolled21 locationsNCT04851119
Recruiting
Phase 1
Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer
Resectable Head and Neck Squamous Cell CarcinomaHuman Papillomavirus-Negative Neck Squamous Cell CarcinomaResectable Human Papillomavirus-Independent Head and Neck Mucosal Squamous Cell Carcinoma+1 more
Mayo Clinic24 enrolled1 locationNCT06997094
Recruiting
Phase 1
HPV DNA Vaccine Via Electroporation for HPV16 Positive Cervical Neoplasia
Human Papillomavirus Type 16Cervical Intraepithelial Neoplasia Grade IICervical Intraepithelial Neoplasia, Grade III
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins48 enrolled2 locationsNCT04131413
Recruiting
Phase 1Phase 2
A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
Advanced Solid TumorsCarcinomaNeoplasms+9 more
Marengo Therapeutics, Inc.365 enrolled32 locationsNCT05592626
Recruiting
Phase 1Phase 2
Effect of Honey For CIN II
Cervical Intraepithelial Neoplasia-IIHigh Risk Human Papillomavirus
Zuyderland Medisch Centrum60 enrolled2 locationsNCT06219018
Recruiting
Phase 1
Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery
Oropharyngeal CancerSquamous Cell CarcinomaHuman Papilloma Virus+1 more
Ryan Carey30 enrolled1 locationNCT06747390
Recruiting
Phase 1Phase 2
HUC-MSC for Treatment of High-risk HPV Infection
Human Papillomavirus VirusesMesenchymal Stem Cells
Shanghai East Hospital60 enrolled1 locationNCT06610773
Recruiting
Phase 1
SCG142 TCR-T Cells for Human Papillomavirus-Associated Carcinomas
Cervical CancerAnal CancerPenile Cancer+5 more
The Affiliated Hospital of Qingdao University18 enrolled1 locationNCT06544720
Recruiting
Phase 1Phase 2
Clinical Study of Curcumin in Preventing Postoperative Adhesion of Bilateral Vocal Cords
Glottic CarcinomaGlottic Web of LarynxLaryngeal Stenosis+3 more
Eye & ENT Hospital of Fudan University100 enrolled1 locationNCT05688488
Completed
Phase 1
A Randomised, Double-Blind, Vehicle-Controlled Study of the Safety and Tolerability of BTX 1702 in Patients with Papulopustular Rosacea
Papulopustular Rosacea
Botanix Pharmaceuticals Ltd120 enrolled1 locationACTRN12621000689875
Withdrawn
Phase 1
A Randomised, Double-Blind, Vehicle-Controlled Study of the Safety and Tolerability of Two Dosage Forms of BTX 1702 in Patients with Papulopustular Rosacea
Papulopustular Rosacea
Botanix Pharmaceuticals Ltd120 enrolled1 locationACTRN12620000184976
Not Yet Recruiting
Phase 1
A study comparing Brincidofovir administered as an oral suspension versus Intravenous Formulation in Japanese and Non-Japanese Adult Volunteers
Viral Infection - orthopoxvirusesViral Infection - polyomavirusesViral Infection - human herpesviruses (HHV)+2 more
Chimerix Inc.36 enrolled1 locationACTRN12618002011268
Not Yet Recruiting
Phase 1
Efficacy of iodine solution administered via a treatment applicator for treating human papillomavirus (HPV) infection of the cervix.
Cervical human papillomavirus infection
Jenny McClloskey60 enrolled1 locationACTRN12617000726358