Paraplegia Clinical Trials

2 recruiting

Frequently Asked Questions

Common questions about Paraplegia clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 30 trials

Recruiting

STOP-HSP.Net: a Registry for Hereditary Spastic Paraplegia as an Integration Tool for Future Therapeutic Strategies

Hereditary Spastic Paraplegia
IRCCS Fondazione Stella Maris500 enrolled1 locationNCT06572046
Recruiting

Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)

Movement DisordersMotor Neuron DiseaseHereditary Spastic Paraplegia+3 more
Boston Children's Hospital200 enrolled1 locationNCT05354622
Recruiting

Registry and Natural History Study for Early Onset Hereditary Spastic Paraplegia

Hereditary Spastic ParaplegiaSPG47SPG50+8 more
Boston Children's Hospital700 enrolled1 locationNCT04712812
Recruiting

Spastic Paraplegia - Centers of Excellence Research Network

Neuromuscular DiseasesPrimary Lateral SclerosisHereditary Spastic Paraplegia+6 more
Boston Children's Hospital100 enrolled11 locationsNCT06553976
Recruiting
Not Applicable

Effects of Whole-body Electrical Muscle Stimulation Exercise on Adults With Neuromuscular Disease

Myasthenia GravisAmyotrophic Lateral SclerosisNeuromuscular Diseases (NMD)+15 more
University of Missouri-Columbia50 enrolled1 locationNCT07478172
Recruiting

Genetic and Physical Study of Childhood Nerve and Muscle Disorders

Muscular DystrophiesMuscle MyopathiesHereditary Spastic Paraplegias+2 more
National Institute of Neurological Disorders and Stroke (NINDS)9,300 enrolled1 locationNCT01568658
Recruiting
Not Applicable

Effects of a Supervised Rehabilitation Program on Disease Severity in Spastic Ataxias

Autosomal Recessive Spastic Ataxia of Charlevoix-SaguenaySpastic Paraplegia 7
Laval University84 enrolled5 locationsNCT06261424
Recruiting
Not Applicable

Neuromodulation to Enhance Motor Function in HSP

Hereditary Spastic Paraplegia
Rahul Sachdeva15 enrolled1 locationNCT07417943
Recruiting
Not Applicable

Self-balancing Personal Exoskeleton for SCI (WINY)

Spinal Cord InjuryParaplegia and Tetraplegia
Wandercraft12 enrolled1 locationNCT07222033
Recruiting
Not Applicable

Self-balancing Personal Exoskeleton for SCI

Spinal Cord Injuries (SCI)Paraplegia and Tetraplegia
Wandercraft24 enrolled1 locationNCT06777576
Recruiting
Not Applicable

Self-balancing Personal Exoskeleton for SCI (Site 2)

Spinal Cord Injuries (SCI)Paraplegia and Tetraplegia
Wandercraft24 enrolled1 locationNCT06814015
Recruiting
Phase 3

Phase 3 Efficacy Study With Concurrent Control of IT MELPIDA in SPG50.Concurrent Controls.

Hereditary Spastic Paraplegia Type 50
Elpida Therapeutics SPC24 enrolled2 locationsNCT06692712
Recruiting
Not Applicable

Brain Controlled Spinal Cord Stimulation In Participants With Spinal Cord Injury For Lower Limb Rehabilitation

Spinal Cord InjuriesParaplegia
Ecole Polytechnique Fédérale de Lausanne3 enrolled1 locationNCT06243952
Recruiting

A Natural History Study Seeks to Understand the Clinical, Genomic, Pharmacological, Laboratory, and Dietary Determinates of Pyrimidine and Purine Metabolism Disorders

Metabolic DiseaseAMPD3, OMIM*102772, AMP Deaminase DeficiencyAK1, OMIM *103000, Adenylate Kinase Deficiency+25 more
National Human Genome Research Institute (NHGRI)999 enrolled1 locationNCT06092346
Recruiting
Not Applicable

Gait Analysis Parameter and Upper Limb Evaluation in Adult Patients With Neurological or Metabolic Pathology

Myasthenia GravisHuntington DiseaseNeuromuscular Diseases+9 more
Centre Hospitalier Universitaire de Liege300 enrolled1 locationNCT07136844
Recruiting
Not Applicable

Virtual Peer Coaching in Manual Wheelchair Skills

Spinal Cord InjurySpinal Cord Injuries (SCI)Tetraplegia/Tetraparesis+2 more
University of Pittsburgh132 enrolled1 locationNCT06295146
Recruiting

Robot-assisted Walking Treatment in Hereditary Spastic Paraplegia (HSP)

Hereditary Spastic Paraplegia
IRCCS Eugenio Medea50 enrolled1 locationNCT06728787
Recruiting

A Prospective Cohort Study of Surgical Treatment for Foot Deformities in HSP

Hereditary Spastic Paraplegia
Shanghai 6th People's Hospital100 enrolled1 locationNCT06936163
Recruiting

Natural History Study of Patients with HPDL Mutations

Neonatal EncephalopathyGenetic DiseaseMutation+4 more
University of California, San Diego50 enrolled1 locationNCT05848271
Recruiting
Not Applicable

Epidural Stimulation After Neurologic Damage

Spinal Cord InjuriesParaplegia, Complete
University of Minnesota100 enrolled1 locationNCT03026816