Phase 1 Parkinson Disease Clinical Trials
25 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 25 trials
Recruiting
Phase 1
[18F]F-DOPA Imaging in Patients With Autonomic Failure
Multiple System AtrophyParkinson DiseaseDementia With Lewy Bodies+2 more
Daniel Claassen40 enrolled1 locationNCT04246437
Recruiting
Phase 1
This Clinical Trial is Designed to Evaluate the Safety, Tolerability, Feasibility and Preliminary Efficacy of NouvNeu001 (Human Dopaminergic Progenitor Cells Injection) in Patients With Parkinson's Disease.
Parkinson Disease
iRegene Therapeutics Co., Ltd.5 enrolled1 locationNCT07102342
Recruiting
Phase 1Phase 2
Safety and Tolerability of IRL757 in Participants With Parkinson's Disease and Apathy
SafetyPARKINSON DISEASE (Disorder)Apathy
Integrative Research Laboratories AB75 enrolled13 locationsNCT07461220
Recruiting
Phase 1
SAD Study in Patients With Parkinson's Disease and Motor Fluctuations
PARKINSON DISEASE (Disorder)Advanced Parkinson's Disease
Serina Therapeutics40 enrolled4 locationsNCT07422675
Recruiting
Phase 1
A Study of LY4006896 in Healthy Participants and Participants With Parkinson's Disease
Parkinson Disease
Eli Lilly and Company127 enrolled14 locationsNCT06809400
Recruiting
Phase 1Phase 2
Feasibility Study Assessing the Effect of Carbidopa/Levodopa Ratio on Orthostatic Hypotension in Multiple System Atrophy - Parkinsonian Type and Parkinson Disease.
Parkinson DiseaseOrthostatic Hypotension, DysautonomicMulti-system Atrophy - Parkinsonian Type
Julien Bally36 enrolled2 locationsNCT06831500
Recruiting
Phase 1Phase 2
Virtual tES Device Treatment for Parkinson's Disease Motor Symptoms
PARKINSON DISEASE (Disorder)
U: The Mind Company30 enrolled1 locationNCT07182058
Recruiting
Phase 1Phase 2
Clinical Study to Evaluate XS411 in Treatment of Early-onset Parkinson's Disease
Parkinson Disease (PD)
XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.90 enrolled1 locationNCT07166757
Recruiting
Phase 1Phase 2
Celecoxib in Parkinson Disease as Adjuvant Therapy
Parkinson Disease
Tanta University80 enrolled1 locationNCT07246278
Recruiting
Phase 1Phase 2
Phase 2 Trial of Tributyrin in People With Parkinson's Disease and Cognitive Impairments
Parkinson DiseaseParkinson Disease Dementia
Prabesh Kanel45 enrolled1 locationNCT07154511
Recruiting
Phase 1Phase 2
Evaluation of Long-term Safety in Parkinsonian Patients With Intracerebroventricular Administration of A-dopamine (Anaerobic Dopamine)
Parkinson Disease
University Hospital, Lille1 enrolled1 locationNCT07214285
Recruiting
Phase 1
Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure
Multiple System AtrophyParkinson DiseaseAutonomic Failure+2 more
Vanderbilt University Medical Center34 enrolled1 locationNCT02897063
Recruiting
Phase 1
Testing if PDR-001 Can Safely and Effectively Remove Harmful Brain Protein in Parkinson's Disease
Parkinson Disease (PD)
Ruijin Hospital12 enrolled1 locationNCT07157345
Recruiting
Phase 1
A Trial to Evaluate the Safety, Tolerability and Preliminary Efficacy of NCR201 in the Treatment of Subjects With Parkinson's Disease
Parkinson Disease
Nuwacell Biotechnologies Co., Ltd.48 enrolled1 locationNCT06978920
Recruiting
Phase 1
First-in-Human Single and Multiple Dose of HL-400
Parkinson Disease
Highlightll Pharmaceutical (USA) LLC54 enrolled1 locationNCT06997484
Recruiting
Phase 1
A Two-Part Single and Multiple Ascending Dose Trial of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LBT-3627 in Healthy Participants and in Participants With Parkinson's Disease.
Parkinson Disease
Longevity Biotech Australia Pty Ltd (subsidiary)64 enrolled2 locationsNCT06466525
Recruiting
Phase 1
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GT-02287 in Parkinson's Disease
Parkinson Disease
Gain Therapeutics, Inc.20 enrolled7 locationsNCT06732180
Recruiting
Phase 1
Treating Parkinson's Disease Through Transplantation of Autologous Stem Cell-Derived Dopaminergic Neurons
Parkinson Disease
Jeffrey S. Schweitzer, MD, PhD8 enrolled1 locationNCT06687837
Recruiting
Phase 1Phase 2
Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers
Amyotrophic Lateral Sclerosis(ALS)Alzheimer Disease (AD)Parkinson Disease (PD)+1 more
Ashvattha Therapeutics, Inc.65 enrolled3 locationsNCT05395624
Recruiting
Phase 1
Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cell Exosomes for Parkinson's Disease
Parkinson Disease
The Foundation for Orthopaedics and Regenerative Medicine20 enrolled1 locationNCT05152394