Phase 1 Pediatric Clinical Trials
34 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 34 trials
Recruiting
Phase 1
Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors
Advanced Breast CancerAdvanced Solid TumorsMetastatic Pancreatic Cancer+3 more
National Cancer Institute (NCI)116 enrolled2 locationsNCT04222413
Recruiting
Phase 1
CD45RA-depleted CD19-CAR T Cell Consolidation After TCRαβ+/CD19 B Cell-depleted Haploidentical Hematopoietic Cell Transplantation for Relapsed/Refractory CD19+ ALL and Lymphoma
Hematologic MalignancyRelapsed Pediatric ALLHematopoietic Cell Transplantation
St. Jude Children's Research Hospital60 enrolled1 locationNCT07257419
Recruiting
Phase 1
B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)
Soft Tissue SarcomaMelanomaCarcinoma+13 more
St. Jude Children's Research Hospital48 enrolled1 locationNCT04897321
Recruiting
Phase 1
HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors
NeoplasmsNeoplasms by SiteBrain Diseases+30 more
M.D. Anderson Cancer Center24 enrolled3 locationsNCT03911388
Recruiting
Phase 1
Targeting Pediatric Brain Tumors and Relapsed/Refractory Solid Tumors With Sodium Glucose Cotransporter 2 Inhibitors (SGLT2i)
Pediatric Solid TumorPediatric Brain Tumor
Washington University School of Medicine20 enrolled1 locationNCT05521984
Recruiting
Phase 1
Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Pediatric Brain Tumors
Pediatric Brain TumorRecurrent Pediatric Brain TumorPediatric Neoplasm
Sabine Mueller, MD, PhD24 enrolled10 locationsNCT05887882
Recruiting
Phase 1Phase 2
Lurbinectedin in FET-Fused Tumors
Ewing SarcomaPediatric CancerDesmoplastic Small Round Cell Tumor+1 more
Children's Hospital of Philadelphia63 enrolled6 locationsNCT05918640
Recruiting
Phase 1Phase 2
Safety and Efficacy of Cyclophosphamide, Sorafenib, Bevacizumab, and Atezolizumab in Pediatric Solid Tumor Patients
Hepatocellular CarcinomaRefractory Solid TumorPediatric Solid Tumor+3 more
St. Jude Children's Research Hospital64 enrolled2 locationsNCT05468359
Recruiting
Phase 1
Haploidentical Hematopoietic Stem Cell Transplantation With Ex Vivo TCR Alpha/Beta and CD19 Depletion in Pediatric Hematologic Malignancies
Pediatric Hematologic Malignancies
Washington University School of Medicine50 enrolled1 locationNCT05011422
Recruiting
Phase 1
Safety and Efficacy of CMD03 CAR T Cell in Children With Relapse or Refractory Solid Tumors
Pediatric CancersSolid Tumor Pediatric
Chulalongkorn University9 enrolled1 locationNCT06612645
Recruiting
Phase 1Phase 2
Phase 1/2 Study of Mirdametinib + Vinblastine for Newly Diagnosed/Previously Untreated PLGG + Activation of MAPK
Pediatric Low-grade Glioma
St. Justine's Hospital50 enrolled5 locationsNCT06666348
Recruiting
Phase 1Phase 2
Anti-CD19, Dual Co-stimulatory (4-1BB, CD3ζ) Chimeric Antigen Receptor T-cells in Patients With Relapsed/Refractory Aggressive Lymphoma or Acute Lymphoblastic Leukemia (ALL)
Relapsed Pediatric ALLRelapsed Non Hodgkin LymphomaRelapsed Adult ALL
University of Alberta63 enrolled6 locationsNCT03938987
Recruiting
Phase 1
A Phase I Study Investigating the Combination of the Ziftomenib, Venetoclax and Azacitidine in Pediatric Relapsed and Refractory Acute Leukemias
Refractory Acute LeukemiaPediatric Relapsed
M.D. Anderson Cancer Center22 enrolled1 locationNCT06397027
Recruiting
Phase 1Phase 2
A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue
Pediatric Sarcoma, RefractoryPediatric Sarcoma, Relapsed
Nationwide Children's Hospital50 enrolled22 locationsNCT05634369
Recruiting
Phase 1
GPC2-CAR T Cell Therapy for Relapsed or Refractory Medulloblastoma in Children and Young Adults
Pediatric Brain TumorPineoblastomaMedulloblastoma+7 more
Stanford University18 enrolled1 locationNCT07087002
Recruiting
Phase 1Phase 2
European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors
Pediatric Cancer
Gustave Roussy, Cancer Campus, Grand Paris472 enrolled21 locationsNCT02813135
Recruiting
Phase 1
Dolutegravir Pharmacokinetics Among HIV/TB Coinfected Children Receiving Standard and High-dose Rifampicin
Pediatric HIV InfectionTuberculosis Infection
Brigham and Women's Hospital20 enrolled1 locationNCT05069688
Recruiting
Phase 1
Neoepitope-based Personalized DNA Vaccine Approach in Pediatric Patients With Recurrent Central Nervous System Tumors
Pediatric Recurrent Central Nervous System Tumors
Washington University School of Medicine7 enrolled1 locationNCT03988283
Recruiting
Phase 1
Clinical Trial of GAIA-102 for Refractory/Relapse Neuroblastomas and Other Malignant Pediatric Solid Tumors
Pediatric Solid TumorsRefractory/Relapse Neuroblastoma
Kyushu University61 enrolled1 locationNCT05608148
Recruiting
Phase 1
A Phase I, First in Human Study of CBA-1205, Anti-DLK1 Monoclonal Antibody in Patients With Advanced Solid Tumors, Hepatocellular Carcinoma (HCC), Melanoma, and Pediatric Cancer
Solid TumorsHepatocellular Carcinoma (HCC)Malignant Melanoma+1 more
Chiome Bioscience Inc.66 enrolled5 locationsNCT06636435