Phase 2 Pediatric Clinical Trials
49 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–20 of 49 trials
Recruiting
Phase 1Phase 2
Phase 1/2 Study of Mirdametinib + Vinblastine for Newly Diagnosed/Previously Untreated PLGG + Activation of MAPK
Pediatric Low-grade Glioma
St. Justine's Hospital50 enrolled8 locationsNCT06666348
Recruiting
Phase 2
Intravesical Aminophylline to Facilitate Ureteroscopic Access in Children With Distal Ureteral Stones.
Ureteral CalculiPediatric UrolithiasisDistal Ureteral Stone
Beni-Suef University60 enrolled1 locationNCT07617896
Recruiting
Phase 2
Intratumoral DNX-2401 for High Grade Pediatric Brain Tumors
RecurrenceRefractoryHigh Grade Glioma+4 more
Clinica Universidad de Navarra, Universidad de Navarra39 enrolled2 locationsNCT07424092
Recruiting
Phase 2
Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic Malformations
PediatricLymphatic Malformation
University Hospital, Lille28 enrolled2 locationsNCT03243019
Recruiting
Phase 1Phase 2
Safety and Efficacy of Cyclophosphamide, Sorafenib, Bevacizumab, and Atezolizumab in Pediatric Solid Tumor Patients
Hepatocellular CarcinomaRefractory Solid TumorPediatric Solid Tumor+3 more
St. Jude Children's Research Hospital64 enrolled2 locationsNCT05468359
Recruiting
Phase 2
Evaluating Efficacy of B7-H3-CAR T Cells Administered at the End of Upfront Map Chemotherapy in Patients With Newly Diagnosed High-Risk Osteosarcoma
Pediatric Osteosarcoma
St. Jude Children's Research Hospital41 enrolled1 locationNCT07428993
Recruiting
Phase 2Phase 3
Cardiorespiratory Fitness in Children and Adolescents After Cancer Treatment.
All Types of Pediatric Cancer
Universität Duisburg-Essen56 enrolled1 locationNCT04765020
Recruiting
Phase 1Phase 2
Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted Haploidentical Transplant in AML
Acute Myeloid LeukemiaAMLAML, Childhood+1 more
Washington University School of Medicine68 enrolled1 locationNCT06158828
Recruiting
Phase 2
Selpercatinib Pre-RAI in Patients With RET Fusion Thyroid Cancer (RAISE)
CancerPediatric CancerDifferentiated Thyroid Cancer+1 more
Children's Hospital of Philadelphia13 enrolled4 locationsNCT06458036
Recruiting
Phase 2Phase 3
A Study to Evaluate the Effect of Aficamten in Pediatric Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy (oHCM).
PediatricSymptomatic Obstructive Hypertrophic Cardiomyopathy
Cytokinetics55 enrolled38 locationsNCT06412666
Recruiting
Phase 2
The Effect of Dormicum-Ketamine Versus Dexmedetomidine on Emergence Delirium During Deep Sedation in Paediatric Burn Patients
Emergence Delirium in Pediatric Anesthesia
Ain Shams University60 enrolled1 locationNCT07519863
Recruiting
Phase 1Phase 2
Lurbinectedin in FET-Fused Tumors
Ewing SarcomaPediatric CancerDesmoplastic Small Round Cell Tumor+1 more
Children's Hospital of Philadelphia63 enrolled6 locationsNCT05918640
Recruiting
Phase 2
Pediatric Acute Respiratory Distress Syndrome (ARDS) Management Trial
Acute Respiratory Distress Syndrome (ARDS)Pediatric Acute Respiratory Distress Syndrome (PARDS)Lung Protective Ventilation+1 more
Children's Hospital of Philadelphia160 enrolled1 locationNCT07123961
Recruiting
Phase 2Phase 3
Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome (MODS)
Nationwide Children's Hospital500 enrolled32 locationsNCT05267821
Recruiting
Phase 2
Orphan Indications for CD19 Redirected Autologous T Cells
Pediatric and Young Adult Patientswith Hypodiploid or t(17;19) B-ALLInfants With Very High Risk KMT2A B-ALLPatients With Central Nervous System Relapse Who Did Not Receive Cranial Radiation or Bone Marrow Transplantation
Stephan Grupp MD PhD133 enrolled1 locationNCT04276870
Recruiting
Phase 2
Checkpoint Inhibition In Pediatric Hepatocellular Carcinoma
Liver CancerFibrolamellar CarcinomaHepatocellular Carcinoma, Childhood+1 more
Allison O'Neill, MD18 enrolled5 locationsNCT04134559
Recruiting
Phase 2Phase 3
A Trial of Remimazolam for Intraoperative Sedation in Pediatric and Adolescent Patients
Operative Sedation of PediatricOperative Sedation of Adolescent Patients
Jiangsu HengRui Medicine Co., Ltd.240 enrolled1 locationNCT07036419
Recruiting
Phase 1Phase 2
Anti-CD19, Dual Co-stimulatory (4-1BB, CD3ζ) Chimeric Antigen Receptor T-cells in Patients With Relapsed/Refractory Aggressive Lymphoma or Acute Lymphoblastic Leukemia (ALL)
Relapsed Pediatric ALLRelapsed Non Hodgkin LymphomaRelapsed Adult ALL
University of Alberta63 enrolled6 locationsNCT03938987
Recruiting
Phase 1Phase 2
A Multi-Institution Study of TGFβ Imprinted, Ex Vivo Expanded Universal Donor NK Cell Infusions as Adoptive Immunotherapy in Combination With Gemcitabine and Docetaxel in Patients With Relapsed or Refractory Pediatric Bone and Soft Tissue
Pediatric Sarcoma, RefractoryPediatric Sarcoma, Relapsed
Nationwide Children's Hospital50 enrolled22 locationsNCT05634369
Recruiting
Phase 2
Immune Function and Response to Vaccination After Cancer Therapy in Pediatric Patients
Pediatric Cancer
Wake Forest University Health Sciences64 enrolled1 locationNCT04948619