Premature Clinical Trials

190 recruitingLast updated: July 25, 2026

There are 190 actively recruiting premature clinical trials across 47 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1. Top locations include Philadelphia, Pennsylvania, United States, Chicago, Illinois, United States, Houston, Texas, United States. Updated daily from ClinicalTrials.gov.


Premature Trials at a Glance

190 actively recruiting trials for premature are listed on ClinicalTrialsFinder across 6 cities in 47 countries. The largest study group is Not Applicable with 99 trials, with the heaviest enrollment activity in Philadelphia, Chicago, and Houston. Lead sponsors running premature studies include Centre Hospitalier Universitaire, Amiens, Assistance Publique - Hôpitaux de Paris, and Duke University.

Browse premature trials by phase

Treatments under study

About Premature Clinical Trials

Looking for clinical trials for Premature? There are currently 17 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Premature trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Premature clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 190 trials

Recruiting
Phase 3

PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis

Coronary Artery Disease ProgressionPremature AtherosclerosisCoronary Artery Disease Risk Factors Multiple+1 more
Duke University1,500 enrolled23 locationsNCT07232069
Recruiting
Phase 2

The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD

Cardiovascular DiseaseSystemic Lupus ErythematosusPremature Atherosclerosis
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)45 enrolled1 locationNCT05440422
Recruiting
Not Applicable

The Effect of Gentle Human Touch and Stimulus Reduction on Pain and Comfort During Heel Blood Collection in Premature Newborns

neonatal intensive care unitNursing CarePremature+1 more
Kubra Nur Kabakcı Sarıdağ60 enrolled1 locationNCT07715682
Recruiting
Phase 1Phase 2

PK, Safety and Preliminary Efficacy Study of Montelukast in Critically Ill Infants With Developing Bronchopulmonary Dysplasia

Critical IllnessBronchopulmonary Dysplasia (BPD)Premature Births
Duke University28 enrolled5 locationsNCT07101640
Recruiting
Not Applicable

Supraglottic Airway for Resuscitation in Preemies

Premature neonatesRespiratory FailureNeonatal resuscitation+5 more
University of Pennsylvania20 enrolled1 locationNCT07419438
Recruiting
Phase 1

A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease

Premature Coronary Heart DiseaseHeterozygous Familial Hypercholesterolemia
Verve Therapeutics, Inc.85 enrolled24 locationsNCT06164730
Recruiting
Phase 3

Hormone Replacement Therapy in Adolescents With Premature Ovarian Insufficiency

Premature Ovarian Insufficiency
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)185 enrolled1 locationNCT06851754
Recruiting
Not Applicable

Preventing Vulnerable Child Syndrome in the NICU With Cognitive Behavioral Therapy (PreVNT Trial)

Premature InfantDevelopment, ChildParent-Child Relations+1 more
University of Texas Southwestern Medical Center100 enrolled1 locationNCT03906435
Recruiting
Phase 2Phase 3

Autologous PRP Infusion May Restore Ovarian Function and May Promote Folliculogenesis in POI Patients

Menopause Related ConditionsPremature Ovarian FailureMenopause, Premature+2 more
Genesis Athens Clinic100 enrolled1 locationNCT04031456
Recruiting

Clinical Safety Guidelines for Managing Distal Shoe Complications

Premature loss of primary molarsSpace MaintainerSoft Tissue Inflammation
University of Florida50 enrolled2 locationsNCT07410442
Recruiting
Not Applicable

A Study Assessing Arrhythmia Mapping With a Multi-Electrode Mapping Catheter

CardiomyopathyVentricular TachycardiaPersistent Atrial Fibrillation+7 more
Biosense Webster, Inc.90 enrolled6 locationsNCT07116525
Recruiting

Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

Premature BirthInfant, Extremely PrematureObstetric Labor, Premature+2 more
The University of Texas Health Science Center, Houston5,000 enrolled59 locationsNCT05685745
Recruiting

Follow-up Visit of High Risk Infants

Infant, NewbornInfant, Low Birth WeightInfant, Small for Gestational Age+1 more
NICHD Neonatal Research Network68,000 enrolled31 locationsNCT00009633
Recruiting
Not Applicable

Effect of the IBAIP in Preterm Infants Neurodevelopment

Premature Birth
University Hospital, Brest240 enrolled9 locationsNCT04685356
Recruiting

The UK 22 Week Study

Infant, Extremely PrematureIntensive Care, NeonatalExtreme Prematurity - Less Than 28 Weeks+1 more
Imperial College London100 enrolled50 locationsNCT07616778
Recruiting
Phase 4

Caffeine Citrate in Preterm Infants at Risk of Apnea in Zambia

Apnea of PrematurityDevelopment, InfantPremature Infant Disease
University of Alabama at Birmingham340 enrolled1 locationNCT06518603
Recruiting
Phase 4

Use of Adenosine to Determine the Electrophysiological Mechanism of Premature Ventricular Contractions

Premature Ventricular Contraction (PVC)
Weill Medical College of Cornell University100 enrolled1 locationNCT03218137
Recruiting
Phase 3

TAILORED Therapeutic Regime in Patients With Preterm Premature Rupture Of Membranes to Prolong Pregnancy, Improve Maternal and Neonatal Outcomes, and Reduce Antibiotic Burden

Preterm premature rupture of membranes (PPROM)
The Central and Eastern European Gynecologic Oncology Group138 enrolled3 locationsNCT07107477
Recruiting
Not Applicable

Early DHA/ARA Supplementation in Growth-restricted Very Preterm Infants: A Randomized Clinical Trial

PrematureInfant MalnutritionLight-For-Dates With Signs of Fetal Malnutrition+1 more
University of Alabama at Birmingham152 enrolled1 locationNCT06207071
Recruiting
Not Applicable

Pain Relief in Premature Newborns Through Maternal Intervention During Venipuncture

premature newborns
University Hospital, Strasbourg, France48 enrolled1 locationNCT06200662