Premature Clinical Trials

182 recruitingLast updated: May 21, 2026

There are 182 actively recruiting premature clinical trials across 46 countries. Studies span Not Applicable, Phase 2, Phase 4, Phase 3, Phase 1. Top locations include Philadelphia, Pennsylvania, United States, Toronto, Ontario, Canada, Columbus, Ohio, United States. Updated daily from ClinicalTrials.gov.


Premature Trials at a Glance

182 actively recruiting trials for premature are listed on ClinicalTrialsFinder across 6 cities in 46 countries. The largest study group is Not Applicable with 96 trials, with the heaviest enrollment activity in Philadelphia, Toronto, and Columbus. Lead sponsors running premature studies include Centre Hospitalier Universitaire, Amiens, Assistance Publique - Hôpitaux de Paris, and Boston Medical Group.

Browse premature trials by phase

About Premature Clinical Trials

Looking for clinical trials for Premature? There are currently 16 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Premature trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Premature clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 182 trials

Recruiting
Not Applicable

Improving Outcomes in Early Menopause After Cancer

CancerPremature MenopauseSurgical Menopause+1 more
Duke University117 enrolled1 locationNCT06982677
Recruiting
Not Applicable

Early DHA/ARA Supplementation in Growth-restricted Very Preterm Infants: A Randomized Clinical Trial

PrematureInfant MalnutritionLight-For-Dates With Signs of Fetal Malnutrition+1 more
University of Alabama at Birmingham152 enrolled1 locationNCT06207071
Recruiting

Clinical Safety Guidelines for Managing Distal Shoe Complications

Premature loss of primary molarsSpace MaintainerSoft Tissue Inflammation
University of Florida50 enrolled2 locationsNCT07410442
Recruiting
Not Applicable

The Periviable GOALS Decision Support Tool

Pregnancy ComplicationsPremature BirthObstetric Labor, Premature+2 more
Indiana University300 enrolled12 locationsNCT05264779
Recruiting
Not Applicable

Optimising Breathing Support at Extubation in Very Preterm Infants: A Clinical Study

Respiratory Distress Syndrome in Premature InfantRespiratory Distress Syndrome, Newborn
Murdoch Childrens Research Institute134 enrolled2 locationsNCT07251790
Recruiting
Not Applicable

Effects of Intelligent Parent-child Bonding Intervention on the Physical, Psychological and Social Health of Parents of Premature Infants During Hospitalization and Return Home

Parents of Premature InfantsIntelligent InterventionParent-child Connection
National Defense Medical Center, Taiwan360 enrolled1 locationNCT06987227
Recruiting

Defining the Risk of Ventricular Tachycardia in Genetic Cardiomyopathies

Atrial FibrillationVentricular TachycardiaPremature Ventricular Contraction
Vanderbilt University Medical Center200 enrolled1 locationNCT06575881
Recruiting

Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

Premature BirthInfant, Extremely PrematureObstetric Labor, Premature+2 more
The University of Texas Health Science Center, Houston5,000 enrolled51 locationsNCT05685745
Recruiting
Phase 4

Calfactant vs Poractant Alfa Using a Less Invasive Technique in Preterm Infants With Respiratory Distress Syndrome

SurfactantRespiratory Distress Syndrome in Premature InfantsRespiratory Distress Syndrome (RDS)
Uludag University234 enrolled5 locationsNCT07350018
Recruiting
Phase 3

Hormone Replacement Therapy in Adolescents With Premature Ovarian Insufficiency

Premature Ovarian Insufficiency
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)185 enrolled1 locationNCT06851754
Recruiting
Not Applicable

Supraglottic Airway for Resuscitation in Preemies

Premature neonatesRespiratory FailureNeonatal resuscitation+5 more
University of Pennsylvania20 enrolled1 locationNCT07419438
Recruiting
Phase 4

I.V Papavrine for Labor Induction in Term PROM

Premature Rupture of Membranes
Western Galilee Hospital-Nahariya110 enrolled1 locationNCT07517796
Recruiting
Phase 2

The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD

Cardiovascular DiseaseSystemic Lupus ErythematosusPremature Atherosclerosis
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)45 enrolled1 locationNCT05440422
Recruiting
Phase 2

Co-administration of Acetaminophen With Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants

Patent Ductus Arteriosus After Premature Birth
Mount Sinai Hospital, Canada310 enrolled9 locationsNCT05340582
Recruiting
Phase 1

A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease

Premature Coronary Heart DiseaseHeterozygous Familial Hypercholesterolemia
Verve Therapeutics, Inc.85 enrolled22 locationsNCT06164730
Recruiting
Not Applicable

Real-Time Intracardiac Echocardiography for Ventricular Arrhythmia Ablation

Ventricular TachycardiaVentricular ArrhythmiaAblation of Arrhythmias+1 more
Insel Gruppe AG, University Hospital Bern70 enrolled2 locationsNCT07201506
Recruiting
Not Applicable

Healing Tiny Minds: Rural Recovery Through Virtual and Lived Experience Care

Cerebral PalsyPremature BirthNeurological Disorder+1 more
University of Wisconsin, Madison225 enrolled1 locationNCT06643598
Recruiting
Phase 4

Pragmatic Evaluation of Respiratory Distress Syndrome Treatment in Africa

Premature BirthRespiratory Distress Syndrome in Premature InfantSurfactant Deficiency Syndrome Neonatal+1 more
Indiana University1,512 enrolled8 locationsNCT06554522
Recruiting

Neonatal Data and Biobank to Study Factors Influencing Development in Preterm Infants Born at <32 Weeks' Gestation and/or <1500 g Birth Weight

Premature BirthPrematurity ComplicationsPreterm Infant Health+1 more
University Hospital of Cologne1,300 enrolled1 locationNCT07490912
Recruiting

Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting

Transient Tachypnea of the NewbornPneumothoraxRespiratory Distress Syndrome in Premature Infant+5 more
Mayo Clinic500 enrolled1 locationNCT07344714