Phase 2 Rectal Adenocarcinoma Clinical Trials
19 recruitingPhase 2
What is a Phase 2 trial?
Phase 2 trials evaluate whether a treatment works for a specific condition and further assess its safety. These studies typically enroll several hundred participants and provide preliminary data on effectiveness.
Showing 1–19 of 19 trials
Recruiting
Phase 2
A Study of Botensilimab and Balstilimab for Rectal Adenocarcinoma
Locally Advanced Rectal AdenocarcinomaMicrosatellite Stable Rectal Carcinoma
Memorial Sloan Kettering Cancer Center40 enrolled7 locationsNCT06843434
Recruiting
Phase 1Phase 2
A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression
Colorectal, CancerOvarian CancerLung Cancer+17 more
A2 Biotherapeutics Inc.474 enrolled12 locationsNCT06051695
Recruiting
Phase 1Phase 2
Testing the Effectiveness of the Anti-cancer Drug Pidnarulex (CX-5461), in Combination With Another Anti-cancer Drug Cemiplimab (REGN2810), in Treating Refractory Microsatellite Stable Colorectal Cancer
Stage IV Colorectal Cancer AJCC v8Stage III Colorectal Cancer AJCC v8Metastatic Colorectal Adenocarcinoma+2 more
National Cancer Institute (NCI)86 enrolled1 locationNCT07147231
Recruiting
Phase 2
A Study of Tucatinib and Trastuzumab in People With Rectal Cancer
Rectal CancerRectal AdenocarcinomaAdenocarcinoma of the Rectum+2 more
Memorial Sloan Kettering Cancer Center37 enrolled7 locationsNCT05672524
Recruiting
Phase 1Phase 2
Dual-Targeting CAR-NK Cells in Biomarker-Selected Advanced Colorectal Cancer
Colorectal, CancerMetastatic Colorectal AdenocarcinomaUnresectable Colorectal Cancer
Beijing Biotech48 enrolled1 locationNCT07589517
Recruiting
Phase 2
Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors
Solid TumorSolid Tumor, AdultRectal Adenocarcinoma+2 more
Memorial Sloan Kettering Cancer Center212 enrolled10 locationsNCT04165772
Recruiting
Phase 2
Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy
Rectal Adenocarcinoma
M.D. Anderson Cancer Center60 enrolled1 locationNCT06569368
Recruiting
Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
Rectal CancerRectal Adenocarcinoma
University of Colorado, Denver44 enrolled3 locationsNCT07292298
Recruiting
Phase 1Phase 2
A Study of VS-6766 and Cetuximab in Patients With Advanced Colorectal Cancer
Colorectal, CancerAdvanced Colorectal CarcinomaAdvanced Colorectal Adenocarcinoma+2 more
University of Chicago53 enrolled1 locationNCT05200442
Recruiting
Phase 2
Upfront Trastuzumab-Deruxtecan Plus Capecitabine and Bevacizumab for Patients With HER-2 Positive Metastatic Colorectal Cancer.
Colorectal, CancerRectal AdenocarcinomaColorectal Adenocarcinoma+4 more
Gruppo Oncologico del Nord-Ovest42 enrolled28 locationsNCT07407465
Recruiting
Phase 2
Amplitude-Modulated Radiofrequency Electromagnetic Fields (AM RF EMF) in Combination With Fruquintinib in Refractory Metastatic Colorectal Cancer
Metastatic Colorectal Adenocarcinoma
Barbara Ann Karmanos Cancer Institute102 enrolled9 locationsNCT07130903
Recruiting
Phase 2
SCRT Followed by CAPOX + Bev ± PD-1 Inhibitor for TNT in LARC
Rectal CancerRectal AdenocarcinomaTargeted Therapy+6 more
Ruijin Hospital104 enrolled1 locationNCT07198165
Recruiting
Phase 2
Pembrolizumab and Odetiglucan in Liver Predominant Metastatic Colorectal Adenocarcinoma
Colorectal Adenocarcinoma Metastatic in the Liver
Abramson Cancer Center at Penn Medicine27 enrolled1 locationNCT07082439
Recruiting
Phase 1Phase 2
A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression
Triple-Negative Breast CancerColorectal, CancerLung Cancer+14 more
A2 Biotherapeutics Inc.240 enrolled10 locationsNCT06682793
Recruiting
Phase 2
FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery
Rectal AdenocarcinomaStage III Rectal Cancer AJCC v8Stage IIA Rectal Cancer AJCC v8
City of Hope Medical Center26 enrolled1 locationNCT06780787
Recruiting
Phase 1Phase 2
AK129 Combination Therapy for Advanced Solid Tumors
Head and Neck Squamous Cell Carcinoma (HNSCC)Advanced Solid TumorsColorectal Adenocarcinoma+1 more
Akeso230 enrolled1 locationNCT06943820
Recruiting
Phase 2
SCRT + mFOLFOX6 + PD-1 Antibody + Targeted Therapy for HIgh-Risk pMMR/MSS Rectal Cancer
Rectal AdenocarcinomaHigh-Risk CancerMSS
Sixth Affiliated Hospital, Sun Yat-sen University49 enrolled1 locationNCT06908031
Recruiting
Phase 2
Encorafenib + Cetuximab Beyond Progression in Combination With FOLFIRI in Patients With BRAF V600E Mutated Metastatic Colorectal Cancer Progressing on Encorafenib + Cetuximab.
Colorectal, CancerColorectal CarcinomaColon Cancer+7 more
Fondazione Policlinico Universitario Agostino Gemelli IRCCS25 enrolled3 locationsNCT06640166
Recruiting
Phase 2
The Efficacy and Safety of Short-course Radiation Combined With Adebrelimab and CAPEOX Neo-adjuvant Therapy for Organ-retention in Patients With MSS/pMMR Ultra Low Rectal Adenocarcinoma
Rectal Adenocarcinoma
Sir Run Run Shaw Hospital30 enrolled1 locationNCT06266832