Rectal Adenocarcinoma Clinical Trials

23 recruiting

Rectal Adenocarcinoma Trials at a Glance

47 actively recruiting trials for rectal adenocarcinoma are listed on ClinicalTrialsFinder across 6 cities in 30 countries. The largest study group is Phase 1 with 14 trials, with the heaviest enrollment activity in Los Angeles, New York, and Houston. Lead sponsors running rectal adenocarcinoma studies include M.D. Anderson Cancer Center, Memorial Sloan Kettering Cancer Center, and National Cancer Institute (NCI).

Browse rectal adenocarcinoma trials by phase

Treatments under study

About Rectal Adenocarcinoma Clinical Trials

Looking for clinical trials for Rectal Adenocarcinoma? There are currently 23 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Rectal Adenocarcinoma trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Rectal Adenocarcinoma clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 47 trials

Recruiting
Phase 1

A Study to Learn More About How Safe BAY 3771249 is and How Well it Works in People With Advanced or Metastatic Colorectal Cancer That Has a KRAS G12D Mutation

Advanced/Metastatic Colorectal Adenocarcinoma
Bayer130 enrolled21 locationsNCT07535112
Recruiting
Phase 3

A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)

Rectal AdenocarcinomaColon Adenocarcinoma
Merck Sharp & Dohme LLC477 enrolled161 locationsNCT06997497
Recruiting
Phase 1

Personalized Peptide Vaccine in Treating Patients With Advanced Pancreatic Cancer or Colorectal Cancer

Metastatic Pancreatic Ductal AdenocarcinomaStage IV Colorectal Cancer AJCC v7Stage IV Pancreatic Cancer AJCC v6 and v7+3 more
M.D. Anderson Cancer Center300 enrolled1 locationNCT02600949
Recruiting
Phase 1Phase 2

Testing the Effectiveness of the Anti-cancer Drug Pidnarulex (CX-5461), in Combination With Another Anti-cancer Drug Cemiplimab (REGN2810), in Treating Refractory Microsatellite Stable Colorectal Cancer

Stage IV Colorectal Cancer AJCC v8Stage III Colorectal Cancer AJCC v8Metastatic Colorectal Adenocarcinoma+2 more
National Cancer Institute (NCI)86 enrolled1 locationNCT07147231
Recruiting
Phase 2

Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy

Rectal Adenocarcinoma
M.D. Anderson Cancer Center60 enrolled1 locationNCT06569368
Recruiting
Phase 1

Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer

Stage IV Colorectal Cancer AJCC v8Stage III Colorectal Cancer AJCC v8Metastatic Colorectal Adenocarcinoma+1 more
National Cancer Institute (NCI)24 enrolled13 locationsNCT06696768
Recruiting
Phase 1

Testing the Addition of Anti-cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment, Cetuximab Plus Encorafenib, for Colorectal Cancer

Stage IV Colorectal Cancer AJCC v8Metastatic Colorectal AdenocarcinomaRecurrent Colorectal Adenocarcinoma+1 more
National Cancer Institute (NCI)30 enrolled15 locationsNCT06102902
Recruiting
Not Applicable

Measurement of MMP-14 Protein, a Potential New Marker for Colorectal Cancer Detection, in Plasma Vesicles Named Exosomes

Colorectal Adenocarcinoma
CHU de Reims650 enrolled1 locationNCT06955767
Recruiting
Phase 3

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, The ERASur Study

Stage IV Colorectal Cancer AJCC v8Metastatic Colorectal Adenocarcinoma
Alliance for Clinical Trials in Oncology364 enrolled183 locationsNCT05673148
Recruiting
Phase 2

Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

Rectal CancerRectal Adenocarcinoma
University of Colorado, Denver44 enrolled3 locationsNCT07292298
Recruiting

Evaluation of Quality of Life and Utilities Following Surgical Treatment of Stage I-IV Rectal Cancer

Rectal AdenocarcinomaStage II Rectal Cancer AJCC v8Stage III Rectal Cancer AJCC v8+11 more
M.D. Anderson Cancer Center430 enrolled1 locationNCT02107105
Recruiting
Phase 1

Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer

Rectal AdenocarcinomaLocally Advanced Rectal CarcinomaStage II Rectal Cancer AJCC v8+7 more
Jonsson Comprehensive Cancer Center25 enrolled1 locationNCT04703101
Recruiting
Phase 1

Botensilimab Plus Balstilimab and Fasting Mimicking Diet Plus Vitamin C for Patients With KRAS-Mutant Metastatic Colorectal Cancer

Stage IV Colorectal Cancer AJCC v8Metastatic Colorectal Adenocarcinoma
University of Southern California15 enrolled3 locationsNCT06336902
Recruiting
Phase 1

MRI-Guided Adaptive Radiation Therapy for Organ Preservation in Rectal Cancer

Rectal Adenocarcinoma
Medical College of Wisconsin22 enrolled1 locationNCT04808323
Recruiting
Not Applicable

Engage Psychosocial Intervention for Cancer Symptoms

Advanced Breast CancerAdvanced Prostate CancerAdvanced Lung Cancer+2 more
Duke University190 enrolled1 locationNCT06555588
Recruiting
Phase 2

A Study of Tucatinib and Trastuzumab in People With Rectal Cancer

Rectal CancerRectal AdenocarcinomaAdenocarcinoma of the Rectum+2 more
Memorial Sloan Kettering Cancer Center37 enrolled7 locationsNCT05672524
Recruiting
Phase 3

AK112 and Chemotherapy in First-line Metastatic Colorectal Cancer

Colorectal Adenocarcinoma
Akeso560 enrolled2 locationsNCT06951503
Recruiting
Not Applicable

A Global, Integrated, Personalized, Stage-related, Multimodal Therapeutic Approach for Rectal Adenocarcinoma Based on Organ Sparing and Mininvasivity

Rectal AdenocarcinomaNon Metastatic
Fondazione del Piemonte per l'Oncologia200 enrolled1 locationNCT06952101
Recruiting
Not Applicable

A Feasibility Study of Mass-Based Response Drug Screening to Guide Personalized Hyperthermic Intraperitoneal Chemotherapy for High-Grade Appendiceal and Colorectal Adenocarcinoma With Peritoneal Metastasis

Colorectal AdenocarcinomaPeritoneal MetastasesAppendiceal Cancer
Yale University20 enrolled1 locationNCT07291180
Recruiting
Phase 1

Trifluridine/Tipiracil and Talazoparib for the Treatment of Patients With Locally Advanced or Metastatic Colorectal or Gastroesophageal Cancer

Locally Advanced Gastroesophageal Junction AdenocarcinomaMetastatic Gastroesophageal Junction AdenocarcinomaStage IV Colorectal Cancer AJCC v8+26 more
Roswell Park Cancer Institute45 enrolled1 locationNCT04511039