Rectal Cancer Stage II Clinical Trials

4 recruiting

Rectal Cancer Stage II Trials at a Glance

11 actively recruiting trials for rectal cancer stage ii are listed on ClinicalTrialsFinder across 6 cities in 16 countries. The largest study group is Phase 2 with 3 trials, with the heaviest enrollment activity in Charleston, Decatur, and Anchorage. Lead sponsors running rectal cancer stage ii studies include Biogenea Pharmaceuticals Ltd., Claus Lindbjerg Andersen, and BioNTech SE.

Browse rectal cancer stage ii trials by phase

Treatments under study

About Rectal Cancer Stage II Clinical Trials

Looking for clinical trials for Rectal Cancer Stage II? There are currently 4 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Rectal Cancer Stage II trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Rectal Cancer Stage II clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 111 of 11 trials

Recruiting
Phase 2

A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer

Colorectal Cancer Stage IIIColorectal Cancer Stage II
BioNTech SE327 enrolled121 locationsNCT04486378
Recruiting
Phase 3

Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors

Colorectal Cancer Stage IIIColorectal Cancer Stage II
SWOG Cancer Research Network1,057 enrolled384 locationsNCT07018869
Recruiting
Not Applicable

Effect of Meal Timing During Cancer Treatment in Patients in Alaska: A Randomized Clinical Trial

Breast Cancer Stage IBreast Cancer Stage IIBreast Cancer Stage III+4 more
Fred Hutchinson Cancer Center100 enrolled1 locationNCT06802172
Recruiting
Early Phase 1

COLONYVAQ™, a Quantum-Classical Guided Personalized Neoantigen Vaccine for MSS Stage III Colorectal Cancer

Colorectal Cancer MetastaticColorectal Cancer Stage IIIColorectal Cancer Stage IV
Biogenea Pharmaceuticals Ltd.12 enrolled1 locationNCT07328087
Recruiting

A Translational Study for Locoregional Recurrence of T4 Colon Cancer

Colorectal Cancer Stage IIIT4 Colorectal CancerColorectal Cancer Stage II
National Taiwan University Hospital60 enrolled1 locationNCT06958926
Recruiting
Phase 3

Bovine Reinforcement in Stomach, Colorectal and Lung Operation

Rectal Cancer Stage IIILung Cancer Stage III
Shanghai Cingularbio Co. Ltd172 enrolled1 locationNCT06968221
Recruiting

GUIDE.MRD-01-CRC: Clinical Validation and Benchmarking of Top Performing CtDNA Diagnostics - Colorectal Cancer

Liver Metastasis Colon CancerColorectal Cancer Stage III
Claus Lindbjerg Andersen590 enrolled15 locationsNCT06111105
Recruiting
Phase 2

Neoadjuvant Regorafenib in Combination with Nivolumab and Short-course Radiotherapy in Stage II-III Rectal Cancer

Rectal Cancer Stage IIRectal Cancer Stage III
Jules Bordet Institute72 enrolled10 locationsNCT04503694
Recruiting

ctDNA Monitoring to Predict the Efficacy of TNT for Rectal Cancer

Rectal CancerRectal Cancer Stage IIRectal Cancer Stage III
Gene Solutions100 enrolled1 locationNCT06589388
Recruiting
Phase 2

The Effects of Neoadjuvant Tislelizumab Combined With Chemotherapy in Locally Advanced MSS Rectal Cancer

Rectal CancerRectal Cancer Stage IIRectal Cancer Stage III
First Affiliated Hospital of Guangxi Medical University60 enrolled1 locationNCT06254521
Recruiting
Phase 4

UGT1A1-Based Irinotecan Therapy for Locally Advanced Rectal Cancer

Rectal Cancer Stage III
Zhejiang Cancer Hospital606 enrolled1 locationNCT05148767