Early Phase 1 Recurrent Clinical Trials
21 recruitingEarly Phase 1
What is a Early Phase 1 trial?
Early Phase 1 trials are the earliest stage of testing in humans. These small studies focus on how a drug is processed in the body and how it affects the body, often enrolling just a handful of participants to establish initial safety data.
Showing 1–20 of 21 trials
Recruiting
Early Phase 1
A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies.
PineoblastomaMedulloblastoma RecurrentEpendymoma Recurrent+3 more
Children's National Research Institute18 enrolled1 locationNCT07017816
Recruiting
Early Phase 1
Merck IIT: RRP Pembro and Lenvatinib
Pulmonary DiseaseRecurrent Respiratory PapillomatosisHuman Papilloma Virus
Yale University20 enrolled1 locationNCT04645602
Recruiting
Early Phase 1
Evaluating Safety, Tolerability, and Preliminary Efficacy of YSCH-01 Monotherapy and in Combination With Atezolizumab for Recurrent Glioblastoma
Recurrent Glioblastoma
Huashan Hospital10 enrolled1 locationNCT07538128
Recruiting
Early Phase 1
Apixaban in Thrombocytopenia
ThrombocytopeniaDeep Vein ThrombosisPulmonary Embolism and Thrombosis+1 more
Rushad Patell30 enrolled1 locationNCT06886516
Recruiting
Early Phase 1
99mTc-PSMA-I&S Biodistribution in Patients With Prostate Cancer
Prostate CarcinomaRecurrent Prostate Carcinoma
Jonsson Comprehensive Cancer Center30 enrolled1 locationNCT04857502
Recruiting
Early Phase 1
Immunological Effects of Vitamin D Replacement Among Black/African American Prostate Cancer Patients
Metastatic Prostate CarcinomaStage IV Prostate Cancer AJCC v8Localized Prostate Carcinoma+1 more
Mayo Clinic220 enrolled2 locationsNCT05045066
Recruiting
Early Phase 1
Simvastatin Treatment to Improve Patient-reported Outcomes in Patients With Chronic Pancreatitis
Chronic PancreatitisRecurrent Acute Pancreatitis
Cedars-Sinai Medical Center90 enrolled5 locationsNCT05771675
Recruiting
Early Phase 1
Sonodynamic Therapy With SONALA-001 or 5-ALA HCL and Magnetic Resonance Guided Focused Ultrasound for the Treatment of Progressive or Recurrent Glioblastoma
Recurrent GlioblastomaProgressive Glioblastoma
Mayo Clinic8 enrolled1 locationNCT07076472
Recruiting
Early Phase 1
Effects of a Probiotic Intervention on the Gut and Vaginal Microbiome in Patients With Advanced or Recurrent Ovarian Cancer Undergoing Treatment With Platinum Chemotherapy
Recurrent Ovarian CarcinomaStage III Ovarian Cancer AJCC v8Stage IV Ovarian Cancer AJCC v8+2 more
Ohio State University Comprehensive Cancer Center161 enrolled1 locationNCT07144826
Recruiting
Early Phase 1
Evaluation of Bridging Radiation Therapy Before CAR T-Cell Infusion for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma
Recurrent Diffuse Large B-Cell LymphomaRefractory Diffuse Large B-Cell Lymphoma
City of Hope Medical Center9 enrolled1 locationNCT05800405
Recruiting
Early Phase 1
the Safety and Efficacy of Targeted BCMA In Vivo LV Injection for Recurrent or Refractory Autoimmune Diseases
Recurrent or Refractory Systemic Lupus ErythematosusRecurrent or Refractory IgG4 Related DiseasesRecurrent or Refractory Systemic Sclerosis+2 more
Tongji Hospital45 enrolled1 locationNCT07339540
Recruiting
Early Phase 1
Multitracer [18F]Fluciclovine and 18F-FDG PET, and Advanced MRI for Metabolic Profiling of Glioblastoma
GlioblastomaRecurrent GlioblastomaGlioblastoma Multiforme of Brain
Abramson Cancer Center at Penn Medicine15 enrolled2 locationsNCT06613841
Recruiting
Early Phase 1
A Surgical Window of Opportunity Clinical Trial of Troriluzole in Recurrent IDH Wild-Type Glioblastoma
Brain TumorGlioblastomaRecurrent Glioblastoma
Ugonma Chukwueke27 enrolled3 locationsNCT06552260
Recruiting
Early Phase 1
Targeting CD19/CD20 Dual-targeted Cell in Patients With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma
B-cell Non-Hodgkin Lymphoma Recurrent B-cell Non-Hodgkin Lymphoma Refractory
Beijing GoBroad Hospital48 enrolled3 locationsNCT07093411
Recruiting
Early Phase 1
A Dose-Expansion Trial of Intravenous HNF4α srRNA for Unresectable or Metastatic Colorectal Cancer
Colorectal Cancer MetastaticColorectal Cancer RecurrentColorectal Cancer Stage IV
Shanghai Changzheng Hospital20 enrolled1 locationNCT07050394
Recruiting
Early Phase 1
High-dose Topotecan for Retinoblastoma With Recurrent or Refractory Vitreous Seed
RetinoblastomaRetinoblastoma, Recurrent
Eye & ENT Hospital of Fudan University10 enrolled1 locationNCT06972602
Recruiting
Early Phase 1
Pilot Trial for Treatment of Recurrent Glioblastoma
GlioblastomaRecurrent GlioblastomaRecurrent Disease
AHS Cancer Control Alberta10 enrolled1 locationNCT05432518
Recruiting
Early Phase 1
An Investigational Scan (rhPSMA-7.3 PET/CT) for Detecting Biochemically Recurrent Prostate Cancer, ENLIGHTEN Trial
Biochemically Recurrent Prostate CarcinomaProstate Adenocarcinoma
Northwestern University27 enrolled1 locationNCT06813898
Recruiting
Early Phase 1
A Novel Probiotic-antibiotic Combination to Prevent Recurrent Urinary Tract Infections
Recurrent Uti
Ann & Robert H Lurie Children's Hospital of Chicago35 enrolled1 locationNCT06149676
Recruiting
Early Phase 1
Exploratory Study on the Safety and Efficacy of Disitamab Vedotin in Combination with Anlotinib Hydrochloride for the Treatment of HER-2-expressing Recurrent Platinum-resistant Ovarian Cancer.
Ovarian Cancer Recurrent
Second Xiangya Hospital of Central South University5 enrolled1 locationNCT06660511