Phase 1 Rheumatoid Arthritis Clinical Trials
34 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 34 trials
Recruiting
Phase 1
Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer
Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmRheumatoid Arthritis+11 more
National Cancer Institute (NCI)300 enrolled52 locationsNCT03816345
Recruiting
Phase 1
A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.
Rheumatoid ArthritisSystemic Lupus ErythematosusIdiopathic Inflammatory Myopathies
AstraZeneca72 enrolled33 locationsNCT06916806
Recruiting
Phase 1
A First-in-human Study of KT501 Administered Subcutaneously to Patients With Rheumatoid Arthritis (RA).
Rheumatoid Arthritis (RA)
Kali Therapeutics, Inc.24 enrolled1 locationNCT07234773
Recruiting
Phase 1
A Clinical Study of MK-1045 in People With Lupus or Rheumatoid Arthritis (MK-1045-004)
Rheumatoid ArthritisSystemic Lupus Erythematosus
Merck Sharp & Dohme LLC21 enrolled3 locationsNCT07363590
Recruiting
Phase 1
An Ascending Dose Study of PIT565 in Participants With Rheumatoid Arthritis
Rheumatoid Arthritis
Novartis Pharmaceuticals57 enrolled12 locationsNCT07029555
Recruiting
Phase 1Phase 2
A Study to Assess Safety, Cellular Kinetics and Exploratory Efficacy of Rapcabtagene Autoleucel in Rheumatoid Arthritis and Sjogren's Disease
Rheumatoid Arthritis (RA) and Sjögren's Disease (SjD)
Novartis Pharmaceuticals27 enrolled10 locationsNCT07048197
Recruiting
Phase 1
Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants
Rheumatoid ArthritisSystemic Lupus Erythematosus
AstraZeneca48 enrolled19 locationsNCT07201558
Recruiting
Phase 1
A Study of AZD0120 in Autoimmune Diseases
Rheumatoid ArthritisIdiopathic Inflammatory MyopathiesSystemic Sclerosis
AstraZeneca27 enrolled18 locationsNCT07295847
Recruiting
Phase 1
An Open-label Study of CND261 in Seropositive Rheumatoid Arthritis
Rheumatoid Arthritis
Candid Therapeutics47 enrolled6 locationsNCT07052032
Recruiting
Phase 1
Study of GS-0151 in Participants With Rheumatoid Arthritis
Rheumatoid Arthritis
Gilead Sciences75 enrolled32 locationsNCT06902519
Recruiting
Phase 1
A Study of LY4213663 in Healthy Participants and Participants With Rheumatoid Arthritis
HealthyRheumatoid Arthritis (RA)
Eli Lilly and Company134 enrolled9 locationsNCT07258849
Recruiting
Phase 1
A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)
Rheumatoid ArthritisSystemic Lupus ErythematosusSystemic Sclerosis+1 more
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company270 enrolled54 locationsNCT05869955
Recruiting
Phase 1
An Open-label Study of Cizutamig in Refractory Seropositive Rheumatoid Arthritis
Rheumatoid Arthritis (RA)
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology28 enrolled1 locationNCT06946199
Recruiting
Phase 1
A Study of F8IL10 Intra-articular Treatment in Rheumatoid Arthritis
Rheumatoid Arthritis (RA)
Philogen S.p.A.42 enrolled2 locationsNCT07245992
Recruiting
Phase 1
A Phase 1 Study of ADI-001 in Rheumatoid Arthritis
Rheumatoid Arthritis (RA)
Adicet Therapeutics25 enrolled1 locationNCT07100873
Recruiting
Phase 1
Phase 1a/b Tolerability of NTR-1011 in Healthy Adults and Adult Patients With SLE and RA
SLE (Systemic Lupus)RA - Rheumatoid Arthritis
Neutrolis48 enrolled1 locationNCT07237659
Recruiting
Phase 1
Safety and Pharmacokinetics of LPX-TI641 in Rheumatoid Arthritis and Psoriatic Arthritis
Psoriatic Arthritis (PsA)Rheumatoid Arthritis (RA)
LAPIX Therapeutics Inc.48 enrolled1 locationNCT06628206
Recruiting
Phase 1
A Phase 1b Open-label Study to Evaluate Safety in Participants With Rheumatoid Arthritis
Rheumatoid Arthritis
Xencor, Inc.47 enrolled4 locationsNCT07230353
Recruiting
Phase 1
The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of SHR-3045 in Healthy Subjects
Rheumatoid Arthritis (RA)
Guangdong Hengrui Pharmaceutical Co., Ltd16 enrolled1 locationNCT07200596
Recruiting
Phase 1
Study of LFD-200 in Healthy Adults and Adults With Moderate to Severe Rheumatoid Arthritis
Rheumatoid Arthritis
Lifordi Immunotherapeutics, Inc.176 enrolled6 locationsNCT07207954